Galya Mihaylova

Vitamin B12 Deficiency in the Diagnostic Work-Up of Global Developmental Delay: A Treatable and Time-Sensitive Condition

Rouzha Pancheva, Maria Dzhogova, Lyubomir Dimitrov, Miglena Nikolova et autres

Background: Vitamin B12 deficiency is a recognized but frequently under-integrated cause of global developmental delay (GDD) in infancy and early childhood. Early diagnosis is critical because neurological impairment may be partially or completely reversible with timely treatment. Objective: This narrative review aims …

bg (code pays fourni par la source)

Effects of Citicoline-Based Supplementation on Lipid Peroxidation Markers and Sirtuin-1 Expression in Ischemic Stroke

Todorka D. Sokrateva, Bogdan H. Roussev, Daniela V. Vankova, Deyana Georgieva Vankova et autres

Ischemic stroke (IS) is associated with pronounced oxidative stress and lipid peroxidation, which contribute to secondary neuronal damage. This study explored the effects of a six-month intervention with a new formulation containing citicoline, vitamin C, and extracts from green tea and aronia …

bg (code pays fourni par la source)

Anti-factor H autoantibodies in patients with lupus nephritis

Galya Mihaylova, Vasil V. Vasilev, M Kosturkova, Mariana Petkova et autres

Lupus nephritis (LN) is a disease marked by autoantibodies against complement components. Autoantibodies against negative complement regulator factor H (anti-FH) are prevalent in aHUS, are associated with deletion of factor H-related protein 1 (FHR1) gene, and have overt functional consequences. They are …

bg (code pays fourni par la source)

Anti-factor H autoantibodies in patients with lupus nephritis

Galya Mihaylova, Vasil V. Vasilev, M Kosturkova, Mariana Petkova et autres

Lupus nephritis (LN) is a disease marked by autoantibodies against complement components. Autoantibodies against negative complement regulator factor H (anti-FH) are prevalent in aHUS, are associated with deletion of factor H-related protein 1 (FHR1) gene, and have overt functional consequences. They are …

bg (code pays fourni par la source)

Clinical Relevance of Anti-C3 and Anti-C4 Autoantibodies in Lupus Nephritis

Vasil V. Vasilev, Mikel Rezola Artero, M Petkova, Galya Mihaylova et autres

Introduction: Complement system overactivation is pivotal in lupus nephritis (LN) pathophysiology. Considering that anti-C3 autoantibodies play a significant role in LN pathophysiology, we explored them as disease activity biomarkers and compared them to the ones against the homologous protein, C4. Methods: = …

bg, fi, fr (code pays fourni par la source)

KRAS Mutation Status in Bulgarian Patients with Advanced and Metastatic Colorectal Cancer

Maria Atanasova Radanova, Galya Mihaylova, George S Stoyanov, Vyara Draganova et autres

RAS somatic variants are predictors of resistance to anti-EGFR therapy for colorectal cancer (CRC) and affect the outcome of the disease. Our study aimed to evaluate the frequency of RAS, with a focus on KRAS variants, and their association with tumor location …

bg (code pays fourni par la source)

Dynamics of Bone Disease Biomarkers Dickkopf-1 and Sclerostin in Patients with Multiple Myeloma

Vladimir Gerov, Daniela Ivanova Gerova, Ilina Micheva, Miglena Nikolova et autres

Dickkopf-1 (DKK-1) and sclerostin are essential Wnt/β-catenin pathway inhibitors, playing an important role in multiple myeloma bone disease (MBD). We aimed to examine the serum DKK-1 and sclerostin variations in newly diagnosed multiple myeloma (NDMM) patients at diagnosis and in the course …

bg (code pays fourni par la source)

Autoantibodies against Complement Classical Pathway Components C1q, C1r, C1s and C1-Inh in Patients with Lupus Nephritis

Maria Atanasova Radanova, Vasil V. Vasilev, Galya Mihaylova, M Kosturkova et autres

Autoantibodies against the complement component C1q (anti-C1q) are among the main biomarkers in lupus nephritis (LN) known to contribute to renal injury. C1q, the recognition subcomponent of the complement classical pathway, forms a heterotetrameric complex with C1r and C1s, and can also …

bg, gb, fr (code pays fourni par la source)

AB0007 ASSOCIATION OF rs172378 VARIANT IN C1q GENE CLUSTER WITH SOME CLINICAL AND IMMUNOLOGICAL ASPECTS OF SYSTEMIC LUPUS ERYTHEMATOSUS IN BULGARIAN PATIENTS

M Kosturkova, T. Shivacheva, Galya Mihaylova, Vasil V. Vasilev et autres

bg (code pays fourni par la source)

P-216 Serum levels of HMGB1 might have a predictive role for neoadjuvant radiotherapy combined with chemotherapy in rectal cancer patients

Temenuzhka Radeva-Petkova, Elitsa Encheva, Galya Mihaylova, D. Palamudova et autres

bg (code pays fourni par la source)

P-271 Frequency of RAS variants in Bulgarian patients with metastatic colorectal cancer

Neshe Ferahova Nazifova-Tasinova, Galya Mihaylova, G. Stoyanov, Oskan Tasinov et autres

bg (code pays fourni par la source)

Association of C1q gene cluster variants with rheumatoid arthritis: a pilot study

M Kosturkova, Galya Mihaylova, T. Shivacheva, Maria Atanasova Radanova

bg (code pays fourni par la source)