Accès ouvert
2026
article
OpenAlex
Andrea Minery, Maria Atanasova Radanova, Lou Segarra, Julie Peliconi et autres
Emerging evidence positions tumour cell-intrinsic complement proteins as regulators of cancer cell behaviour and immune crosstalk, yet their role in triple-negative breast cancer (TNBC) remains undefined. Here, transcriptomic profiling across breast cancer molecular subtypes reveals that C1R, C1S and C3 are preferentially …
fr, bg
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Nikolay Evgeniev, Maria Atanasova Radanova, I.S. Donev, Rumelia Nikolaeva et autres
Nucleosomes play a critical role in the regulation of gene expression and maintaining chromatin structure. In oncology, alterations in histone modifications within nucleosomes have been implicated in the pathogenesis of various cancers, including non-small cell lung cancer (NSCLC). This study investigates the …
bg, ru
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Zhasmina Mihaylova, Stoyan Bichev, Alexey Slavkov Savov, Maria Atanasova Radanova
Background: Anti-EGFR therapy, combined with chemotherapy, represents the standard therapeutic approach for triple wild-type (KRAS/NRAS and BRAF), left-sided, microsatellite stable (MSS) metastatic colorectal cancer (mCRC). However, acquired resistance develops in approximately 50% of patients. This study evaluated the efficacy of anti-EGFR therapy …
bg
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Mikel Rezola Artero, Andrea Minery, Leon Nedelcev, Maria Atanasova Radanova et autres
The hallmarks of cancer are a set of traits that normal cells acquire during their transformation into malignancy. Among the biological processes influencing these hallmarks, the innate immune complement system plays a critical role. It can operate canonically-in blood and tissues-via phagocytosis, …
fr, bg
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Vilhelm Mladenov, Maria Atanasova Radanova, Sonya Galcheva, Violeta Iotova
Background: Polycystic ovary syndrome (PCOS) is the most common hyperandrogenic disorder in reproductive age women. Identifying new biomarkers with high specificity and sensitivity is crucial for diagnosing and monitoring the disease. MiRNAs correlate with PCOS-related comorbidities, suggesting their potential as biomarkers. This …
bg
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Galya Mihaylova, Vasil V. Vasilev, M Kosturkova, Mariana Petkova et autres
Lupus nephritis (LN) is a disease marked by autoantibodies against complement components. Autoantibodies against negative complement regulator factor H (anti-FH) are prevalent in aHUS, are associated with deletion of factor H-related protein 1 (FHR1) gene, and have overt functional consequences. They are …
bg
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Vilhelm Mladenov, Maria Atanasova Radanova, Violeta Iotova
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders, affecting reproductive age women. The etiology and pathogenesis of the syndrome are still not fully understood, but insulin resistance and hyperinsulinemia, neuroendocrine dysfunction leading to elevated luteinizing hormone (LH) levels, …
bg
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Galya Mihaylova, Vasil V. Vasilev, M Kosturkova, Mariana Petkova et autres
Lupus nephritis (LN) is a disease marked by autoantibodies against complement components. Autoantibodies against negative complement regulator factor H (anti-FH) are prevalent in aHUS, are associated with deletion of factor H-related protein 1 (FHR1) gene, and have overt functional consequences. They are …
bg
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Vasil V. Vasilev, Mikel Rezola Artero, M Petkova, Galya Mihaylova et autres
Introduction: Complement system overactivation is pivotal in lupus nephritis (LN) pathophysiology. Considering that anti-C3 autoantibodies play a significant role in LN pathophysiology, we explored them as disease activity biomarkers and compared them to the ones against the homologous protein, C4. Methods: = …
bg, fi, fr
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
R. Gencheva, Mirela Petrova, Petya Kraleva, Savina Petrova Hadjidekova et autres
BACKGROUND AND AIMS: In approximately 40% of patients with HER2-negative/HR-positive breast cancer tumors, the PIK3CA gene is mutated. Despite this, clinical outcomes vary between studies in this cohort. We aimed to ascertain the prevalence of PIK3CA mutations in patients with metastatic HR+/HER2- …
bg
(code pays fourni par la source)
Accès ouvert
2023
book-chapter
OpenAlex
Maria Atanasova Radanova
Transcribed Ultra-Conserved Regions (T-UCRs) are a novel class of long non-coding RNAs derived from Ultra-Conserved Regions (UCRs) of DNA. The discovery of cancer-specific mutations in UCRs and their location in cancer-associated genomic regions suggests that T-UCRs also play a role in carcinogenesis. …
bg
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Maria Atanasova Radanova, Galya Mihaylova, George S Stoyanov, Vyara Draganova et autres
RAS somatic variants are predictors of resistance to anti-EGFR therapy for colorectal cancer (CRC) and affect the outcome of the disease. Our study aimed to evaluate the frequency of RAS, with a focus on KRAS variants, and their association with tumor location …
bg
(code pays fourni par la source)