Effects of Citicoline-Based Supplementation on Lipid Peroxidation Markers and Sirtuin-1 Expression in Ischemic Stroke
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Le résumé fourni par la source
Ischemic stroke (IS) is associated with pronounced oxidative stress and lipid peroxidation, which contribute to secondary neuronal damage. This study explored the effects of a six-month intervention with a new formulation containing citicoline, vitamin C, and extracts from green tea and aronia (Cytodeox™) on arachidonic acid (AA) metabolism, lipid peroxidation assessed by total 8-iso-prostaglandin F2α (8-iso-PGF2α), and Sirtuin-1 (SIRT1) expression in healthy controls (n = 43) and patients with IS (n = 53), both with and without comorbidities. AA and 8-iso-PGF2α were quantified in serum using UPLC–MS and ELISA, respectively, and the fold change in SIRT1 expression was assessed in peripheral blood mononuclear cells (PBMCs) by RT-qPCR. In healthy controls, Cytodeox™ significantly lowered AA and 8-iso-PGF2α levels. IS patients showed markedly increased baseline 8-iso-PGF2α, indicating severe oxidative stress. Following supplementation, 8-iso-PGF2α levels increased in patients with comorbidities, particularly diabetes mellitus (DM), whereas an exploratory analysis suggested a decreasing trend in patients without comorbidities. SIRT1 expression was significantly upregulated in IS patients, with the most pronounced increase observed in the DM subgroup, while remaining unchanged in controls. These findings suggest a protective, antioxidant, and membrane stabilising effect of Cytodeox™ under conditions of preserved or moderately impaired redox homeostasis, supporting its potential role as a preventive or early supportive intervention.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Effects of Citicoline-Based Supplementation on Lipid Peroxidation Markers and Sirtuin-1 Expression in Ischemic Stroke
- Date Crossref
- 15/03/2026
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Medical University of Varna pays non établi dans la noticeUniversité ou école supérieure
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University Hospital St. Marina pays non établi dans la noticeÉtablissement de santé
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Faculty of Pharmacy Department of Biochemistry pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine Department of Neurology and Neuroscience pays non établi dans la noticeUniversité ou école supérieure
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University Hospital “St. Marina” Second Clinic of Neurology with ICU and Stroke Center pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Dental Medicine Department of Clinical Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
Medical University of Varna, University Hospital St. Marina et Department of Biochemistry — Faculty of Pharmacy, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.