Fabiana Conciatori

Interleukin-8 in health and disease

Chiara Bazzichetto, Emanuela Dell’Aquila, Margherita Veroli, Lorenzo Belluomini et autres

Cytokines are among the main factors involved in indirect cell-to-cell communication in physiological and pathological conditions. In this way, cytokines are soluble and tissue-resident easily detectable biomarkers for the diagnosis and the prediction of clinical outcome, as well as drug targets. Over …

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Interleukin-8: a tumor-agnostic biomarker integrating cancer biology and host response across solid tumors

Ilaria Mariangela Scaglione, Chiara Bazzichetto, Michele Borghesani, Francesca Zacchi et autres

Interleukin-8 (IL-8/CXCL8) drives tumor progression via CXCR1/2 signaling, promoting proliferation, invasion, angiogenesis, and recruitment of pro-tumoral immune and stromal cells. Accumulating clinical evidence indicates that elevated circulating or intratumoral IL-8 levels are consistently associated with adverse prognosis and reduced therapeutic benefit across …

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Interleukin-8 as a potential prognostic biomarker in renal cell carcinoma: a systematic review and meta-analysis

Francesca Zacchi, Sara Merler, Ilaria Zampiva, Irene Torresan et autres

BACKGROUND AND OBJECTIVE: Interleukin-8 (IL-8) is a chemokine involved in inflammation and primary immune response, playing a key role in recruiting neutrophils. IL-8 is produced by several cell types, including immune cells and certain cancer cells. Elevated levels of IL-8 have been …

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HER2-Driven Breast Cancer: Role of the Chaperonin HSP90 in Modulating Response to Trastuzumab-Based Therapeutic Combinations

Italia Falcone, Elena Giontella, Sandro Giuliani, Giulia Borghesani et autres

Mechanistic relationships between heat shock protein 90 (HSP90) and human epidermal growth factor receptor 2 (HER2) are complex and clinical correlations in breast cancer remain inconsistent. We investigated the role of HSP90 expression in the response of breast cancer cells to HER2-targeted …

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Induction of cell death by the CXCR2 antagonist SB225002 in colorectal cancer and stromal cells

Chiara Bazzichetto, Marta Di Martile, Donatella Del Bufalo, Michèle Milella et autres

Molecular targeted therapies have had great success in cancer treatment due to their high efficacy and selectivity. Identifying specific prognostic/predictive biomarkers helps clinicians stratify patients according to individual characteristics and improves patient quality of life in terms of disease control and survival. …

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Preserving momentum on next-generation sequencing for head and neck squamous cell carcinoma

Ilaria Zampiva, Isabella Sperduti, Fabiana Conciatori, Chiara Bazzichetto et autres

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Prognostic impact of Interleukin-8 levels in lung cancer: A meta-analysis and a bioinformatic validation

Lorenzo Belluomini, Ursula Cesta Incani, Annafrancesca Smimmo, Alice Avancini et autres

BACKGROUND: High interleukin-8 (IL-8) levels have been linked to poor prognosis in lung cancer, but conclusive data are lacking. MATERIALS AND METHODS: A comprehensive search was conducted on April 1st, 2023, from electronic databases, focusing on studies with IL-8 expression evaluations and …

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Immunoediting on the Brink: Dynamic Relationship Between Tumor Genotype and Microenvironment as Determinant of Immunotherapy Effectiveness in an informative case report of Lynch Syndrome

Valentina Zen, Sara Cingarlini, Andrea Mafficini, Claudio Luchini et autres

Abstract Background: Lynch syndrome is an autosomal-dominant inherited condition that significantly increases the risk of developing cancer; within the Lynch syndrome spectrum, Muir-Torre syndrome is an autosomal-dominant genodermatosis, associated with keratoacanthomas and sebaceous neoplasms (adenoma, carcinoma or epithelioma). Both are characterized by …

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Prognostic Impact of Interleukin-8 Levels in Lung Cancer: A Meta-Analysis and a Bioinformatic Validation

Lorenzo Belluomini, Ursula Cesta Incani, Annafrancesca Smimmo, Alice Avancini et autres

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Editorial: Tailoring immunotherapy in gastrointestinal cancer: the role of circulating factors

Stefano Ugel, Chiara Bazzichetto, Fabiana Conciatori

Editorial on the Research TopicTailoring immunotherapy in gastrointestinal cancer: the role of circu- lating factors Gastrointestinal (GI) cancer include malignant tumors affecting digestive organs such as esophagus, stomach, liver, pancreas, small intestine, colon and rectum.Its worldwide incidence and mortality are increasing in …

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Bcl-2 family inhibitors sensitize human cancer models to therapy

Elisabetta Valentini, Marta Di Martile, Matteo Brignone, Marica Di Caprio et autres

BH3 mimetics, targeting the Bcl-2 family anti-apoptotic proteins, represent a promising therapeutic opportunity in cancers. ABT-199, the first specific Bcl-2 inhibitor, was approved by FDA for the treatment of several hematological malignancies. We have recently discovered IS21, a novel pan BH3 mimetic …

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Bcl-2 family inhibitors sensitize human cancer models to target therapy

Elisabetta Valentini, Marta Di Martile, Matteo Brignone, Marica Di Caprio et autres

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