Interleukin-8 as a potential prognostic biomarker in renal cell carcinoma: a systematic review and meta-analysis
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Le résumé fourni par la source
BACKGROUND AND OBJECTIVE: Interleukin-8 (IL-8) is a chemokine involved in inflammation and primary immune response, playing a key role in recruiting neutrophils. IL-8 is produced by several cell types, including immune cells and certain cancer cells. Elevated levels of IL-8 have been associated with a poorer outcome in several tumors and have been related to advanced diseases, treatment resistance, and possibly promoting neo angiogenesis and immune cell recruitment. In the renal cell carcinoma (RCC), the prognostic role of IL-8 has not been settled. METHODS: From January 1, 2008 to June 18, 2024, PubMed, Embase, and Scopus databases were searched for all studies investigating the potential prognostic role of IL-8 in RCC. All studies were rated according to the Newcastle-Ottawa Scale. Progression-free survival (PFS) and overall survival (OS) were analyzed as clinical outcomes, and a meta-analysis was performed for both. KEY FINDINGS AND LIMITATIONS: Overall, six papers met the predefined inclusion criteria, with final analyses demonstrating that high IL-8 levels significantly correlate with worse prognosis in RCC, with a statistically shorter PFS (hazard ratio [HR]: 1.27, 95% confidence interval [CI]: 1.01-1.59; P = 0.037) and statistically shorter OS (HR: 1.85, 95% CI: 1.21-2.84; P = .001). Prospective randomized clinical trials are also necessary to investigate the predictive role of IL-8 in the contemporary treatment scenario of RCC to improve clinical decision-making. CONCLUSIONS: This meta-analysis demonstrates the significant prognostic role of IL-8 in RCC, suggesting that IL-8 could be used to refine the prognostic RCC assessment.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Interleukin-8 as a potential prognostic biomarker in renal cell carcinoma: a systematic review and meta-analysis
- Date Crossref
- 21/08/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Verona Department of Engineering for Innovation Medicine pays non établi dans la noticeUniversité ou école supérieure
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Azienda Ospedaliera Universitaria Integrata Verona pays non établi dans la noticeÉtablissement de santé
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Ospedale di Bolzano pays non établi dans la noticeÉtablissement de santé
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Istituto Oncologico Veneto pays non établi dans la noticeÉtablissement de santé
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Casa di Cura Villa Garda pays non établi dans la noticeÉtablissement de santé
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Ospedale P. Pederzoli – Casa di Cura Privata S.p.a. pays non établi dans la noticeÉtablissement de santé
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National Cancer Institute pays non établi dans la noticeOrganisme public
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Istituti di Ricovero e Cura a Carattere Scientifico pays non établi dans la noticeÉtablissement de santé
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Saint Camillus International University of Health and Medical Sciences Saint Camillus International pays non établi dans la noticeUniversité ou école supérieure
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Centro Ricerche Cliniche pays non établi dans la noticeÉtablissement de santé
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San Maurizio Central Hospital of Bolzano Oncology Department pays non établi dans la noticeÉtablissement de santé
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Oncology Unit 1 pays non établi dans la noticeInstitution
Department of Engineering for Innovation Medicine — University of Verona, Azienda Ospedaliera Universitaria Integrata Verona et Ospedale di Bolzano, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.