Interleukin-8 in health and disease
Rattachement africain : it, my. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Cytokines are among the main factors involved in indirect cell-to-cell communication in physiological and pathological conditions. In this way, cytokines are soluble and tissue-resident easily detectable biomarkers for the diagnosis and the prediction of clinical outcome, as well as drug targets. Over the years, the pleiotropic IL-8 gained a central role in the pathogenesis of several immunological disorders, spanning from autoimmune pathologies and sepsis to neurological, liver and cardiovascular diseases. In several solid cancers, IL-8 not only serves as a prognostic biomarker but also as predictive tool. Increasing evidence highlighted IL-8 as a prognostic/predictive biomarker even for immunotherapy to stratify eligible patients, to avoid unnecessary toxicity and progression. Today, a comprehensive review covering IL-8 in all these fields has not yet been published. Hence, we aim to provide preclinical and clinical evidence on the biology and functions of IL-8, involved in the pathogenesis of non-malignant diseases, including inflammatory bowel diseases, sepsis, neuroinflammation, liver and cardiovascular pathologies. In oncology area, we will describe the pro-tumorigenic roles, including the characterization of the immunosuppressive microenvironment, also discussing the implications of direct/indirect IL-8 targeting and the involvement of gut microbiota. Unfortunately, the main obstacles to establish IL-8 as a useful non-invasive clinical tool for diagnosis and treatments' selection are the lack of the standardization of method detection and the source of IL-8 production.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Interleukin-8 in health and disease
- Date Crossref
- 09/07/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Istituti di Ricovero e Cura a Carattere Scientifico pays non établi dans la noticeÉtablissement de santé
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University of Verona Department of Engineering for Innovation Medicine (DIMI) pays non établi dans la noticeUniversité ou école supérieure
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Sapienza University of Rome Department of Molecular Medicine pays non établi dans la noticeUniversité ou école supérieure
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Azienda Ospedaliera Universitaria Integrata Verona pays non établi dans la noticeÉtablissement de santé
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National Cancer Institute Division of Medical Oncology 2 pays non établi dans la noticeOrganisme public
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Preclinical Models and New Therapeutic Agents Unit pays non établi dans la noticeÉtablissement de santé
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University and Azienda Ospedaliera Section of General Medicine C and Liver Unit pays non établi dans la noticeUniversité ou école supérieure
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RCSI University of Medicine and Health Sciences FutureNeuro Research Ireland Centre for Translational Brain Science pays non établi dans la noticeUniversité ou école supérieure
Istituti di Ricovero e Cura a Carattere Scientifico, Department of Engineering for Innovation Medicine (DIMI) — University of Verona et Department of Molecular Medicine — Sapienza University of Rome, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.