Isabella Sperduti

Neurocognitive and Neuropsychiatric Trajectories in a Post-COVID Cohort: A Descriptive Longitudinal Study

Giulia Del Duca, Marta Camici, Isabella Sperduti, Anna Clelia Brita et autres

Introduction: Cognitive dysfunction (“brain fog”) is a common manifestation of post-acute COVID-19 syndrome (PACS) and may persist long after the acute infection. While cross-sectional studies have described cognitive deficits, longitudinal evidence on recovery trajectories remains limited. Methods: We conducted a longitudinal observational …

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Ultrahypofractionated radiotherapy better preserves B- and T-cell immunity than conventional fractionated radiotherapy in prostate cancer

Maria Manuela Rosado, Belinda Palermo, Marta Bottero, Serena Masi et autres

Ultrahypofractionated radiotherapy (UHRT) has emerged as an effective treatment option for localized prostate cancer (PCa), but the systemic immunological consequences of different radiotherapy (RT) regimens remain largely overlooked. In particular, the relative contribution of fractionation schedule and irradiation volume to long-term immune …

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Sutureless Purely Off-clamp Robotic Partial Nephrectomy: Evidence from a Randomized Controlled Noninferiority Trial

Aldo Brassetti, Gabriele Tuderti, Umberto Anceschi, Alfredo Maria Bove et autres

BACKGROUND AND OBJECTIVE: The sutureless (SL) purely off-clamp robotic partial nephrectomy (ocRPN) technique has been proposed to minimize postoperative functional damage. We assessed whether this approach is noninferior to renorrhaphy (RR) in terms of surgical quality. METHODS: Patients with cT1-2N0M0 renal tumors …

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108P Giant cell tumor of bone: A retrospective analysis from a sarcoma referral center

F. Riva, C.E. Onesti, S. Vari, Serena Ceddia et autres

Giant cell tumor of bone (GCTB) is a primary bone neoplasm, generally benign but often presents locally behaviour. Despite available surgical and systemic treatments, optimal management remains challenging.

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Determinants of non-compliance with additional booster doses of the SARS-CoV-2 vaccine in people living with HIV (PWH): An observational study based on a behavioral and epidemiological survey in Rome (Italy)

Isabella Sperduti, Alessandro Cozzi‐Lepri, Valentina Mazzotta, Francis Drobniewski et autres

Rejection of new anti-SARS-CoV-2 booster doses among immunosuppressed and elderly individuals may be a concern, especially as the intention to vaccinate does not always translate into actual behavior. Few studies have addressed this issue in people living with HIV (PWH). We investigated …

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Hilar Lymphadenectomy Is Associated With Improved Disease‐Free Survival in Pathologically N0 Non‐Small Cell Lung Cancer

Marco Chiappetta, Carolina Sassorossi, Filippo Lococo, Elisa Meacci et autres

BACKGROUND: Aim of this study is to evaluate the prognostic role of nodal parameter in early stage pathologically patients with N0 who underwent lobectomy and lymphadenectomy. METHODS: Clinical and pathological characteristics of patients who underwent anatomical lung resection from 1/01/2010 to 31/12/2019 …

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P3.14.19 The Role of Tumors Size in Different Thymic Tumors Histology: Results Form the ESTS Thymic Database

M. Chiappetta, Filippo Lococo, Carolina Sassorossi, Bernhard Moser et autres

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Prolonged clinical monitoring of cognitive performance and psychiatric symptoms among PACS

Del Duca Giulia, Isabella Sperduti, Brita Anna Clelia, Monica Della Martina et autres

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PI3K/mTORC2-RICTOR axis in early squamous non-small-cell lung cancer: genomics, molecular expression, and clinical relevance

Sara Pilotto, Lorenzo Belluomini, Federico Monaca, Michele Simbolo et autres

Background: Although considerable discoveries have been made in the genomic landscape of lung adenocarcinoma, to date, little is known regarding potential prognostic factors and altered pathways in resected squamous non-small-cell lung cancer (squamous-NSCLC). Objective: We aimed to analyze the genomic background of …

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Low fT3/fT4 ratio as a proxy for muscle wasting in patients with advanced non-small cell lung cancer treated with pembrolizumab

Serena Eccher, Marco Sposito, Ilaria Trestini, Ilaria Mariangela Scaglione et autres

Background: Loss of skeletal muscle mass may serve as a valuable indicator of treatment efficacy and survival in individuals with lung cancer undergoing immunotherapy. This investigation sought to pinpoint accessible markers that could reflect the presence of muscle degradation. Methods: A retrospective …

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HER2-Driven Breast Cancer: Role of the Chaperonin HSP90 in Modulating Response to Trastuzumab-Based Therapeutic Combinations

Italia Falcone, Elena Giontella, Sandro Giuliani, Giulia Borghesani et autres

Mechanistic relationships between heat shock protein 90 (HSP90) and human epidermal growth factor receptor 2 (HER2) are complex and clinical correlations in breast cancer remain inconsistent. We investigated the role of HSP90 expression in the response of breast cancer cells to HER2-targeted …

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Impact of Ethnicity on Breast Cancer Outcome: A Systematic Review and Meta-Analysis of Randomized Phase III Trials of the Last Decade

Emma Zattarin, Luca Moscetti, Elisa D’Agostino, Alberto Bertolotti et autres

PURPOSE It remains uncertain whether ethnicity affects the benefit derived from novel breast cancer (BC) treatments. Thus, we conducted a systematic review and meta-analysis to evaluate the heterogeneity of treatment efficacy across different ethnic groups, in both the advanced BC (aBC) setting …

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