Mengdie Yang

Dual-locked targeted alpha-emitter enhanced tumor immunotherapy via Diels–Alder reaction-based self-immolative molecular cage strategy

Mengdie Yang, Kang Fang, Xiaoyi Zhang, Gang Yang et autres

Abstract Background Targeted alpha therapy (TAT) has emerged as a promising strategy for cancer treatment by selectively delivering high linear energy transfer (LET) alpha-emitters to tumor cells while minimizing off-target toxicity. However, the clinical translation of alpha-emitters, particularly radium-223 ( 223 Ra), …

cn (code pays fourni par la source)

Advances in Dosimetry and Imaging for 203Pb and 212Pb Radiotheranostics

Keamogetswe Ramonaheng, Milani Qebetu, Kaluzi Banda, Pryaska Goorhoo et autres

Pb, gamma camera performance, dosimetry workflows, and predictive activity quantification, illustrating how these advances collectively enable quantitative, patient-specific, and theranostic-integrated radionuclide therapy.

Afrique du Sud, ch (code pays fourni par la source)

Camouflaged membrane‑bridged radionuclide/Mn single‑atom enzymes target lipid metabolism disruption to evoke antitumor immunity

Mengdie Yang, Xiaoyi Zhang, Yi Zhun Zhu, Miao Chen et autres

Lipid metabolic reprogramming has been increasingly recognized as a key factor contributing to tumor immune evasion, therapeutic resistance, and plasticity, which collectively compromise the efficacy of targeted radionuclide therapy (TRT). Overcoming the immunosuppressive and hypoxic tumor microenvironment (TME) while interfering with tumor …

cn, us (code pays fourni par la source)

Fluorescent imine-linked covalent organic framework turn off sensor for sensitive Co2+ ions detection

Fan Yang, Siqing Liu, Mengdie Yang, Yunxin Zhang et autres

cn (code pays fourni par la source)

Targeted alpha therapy: a comprehensive analysis of the biological effects from “local-regional-systemic” dimensions

Zhiling Song, Jiajia Zhang, Shanshan Qin, Xiaohui Luan et autres

Targeted alpha therapy (TAT) has emerged as a promising radiopharmaceutical modality in precision oncology. Compared to beta-emitters, alpha-emitters exhibit superior properties, including higher linear energy transfer, shorter penetration range, enhanced resistance to hypoxic conditions, and convenient radiation protection. Notably, alpha-emitters also demonstrate …

cn (code pays fourni par la source)

The malignant possibility of intraductal lesions with different ultrasound manifestations under different age and nipple discharge status

Mengdie Yang, Bo Sun, Cai Chang, Yaling Chen et autres

Background: Due to their heterogeneous nature, the diagnosis and treatment of intraductal lesions are controversial. It is not yet clear whether biopsy or open surgery should be recommended for all women with intraductal lesions. We aimed to identify the risk factors of …

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Layered Double Hydroxides for Radium‐223 Targeted Alpha Therapy with Elicitation of the Immune Response

Mengdie Yang, Jianguo Li, Xiaohui Luan, Xiaoyi Zhang et autres

Abstract Targeted Alpha therapy (TAT) has promising application prospects in tumor therapy. It is very appealing to design alpha‐emitting radiopharmaceuticals that can modulate the immune microenvironment to overcome the limitations of immunotherapy. Herein, Mg/Al layered double hydroxide nanomaterials (LDH) are utilized to …

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Recent advances in emerging radiopharmaceuticals and the challenges in radiochemistry and analytical chemistry

Jin Ding, Shanshan Qin, Xingguo Hou, Jiajia Zhang et autres

cn, Éthiopie, us (code pays fourni par la source)

Evaluation of physicochemical and functional properties of protein isolates from 5 edible mushroom species

Qian Zheng, Mengdie Yang, Xiao Chen, Qiping Zhan et autres

Edible mushroom proteins are the promising ones with the advantages of complete essential amino acid profile and multiple functional activities. To reinforce their applications in functional food development, this study comprehensively evaluated the physicochemical and functional properties of protein isolates from 5 …

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Diagnosing postoperative lymph node metastasis in thyroid cancer with multimodal radiomics and clinical features

Xin Fan, Han Zhang, Zhengshi Wang, Xiaoying Zhang et autres

Purpose: This study aims to evaluate the diagnostic value of texture analysis for lymph node metastasis after thyroid cancer surgery. Methods: I treatment at Shanghai Tenth People's Hospital between 2017 and 2020. Clinical follow-up results were used as the criterion for determining …

cn, sg (code pays fourni par la source)

Alpha‐Emitter Radium‐223 Induces STING‐Dependent Pyroptosis to Trigger Robust Antitumor Immunity

Mengdie Yang, Haipeng Liu, Jingjing Lou, Jiajia Zhang et autres

Abstract Radium‐223 (223Ra) is the first‐in‐class alpha‐emitter to mediate tumor eradication, which is commonly thought to kill tumor cells by directly cleaving double‐strand DNA. However, the immunogenic characteristics and cell death modalities triggered by 223Ra remain unclear. Here, it is reported that …

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Effective Treatment of SSTR2-Positive Small Cell Lung Cancer Using 211 At-Containing Targeted α-Particle Therapy Agent Which Promotes Endogenous Antitumor Immune Response

Shanshan Qin, Yuanyou Yang, Jiajia Zhang, Yuzhen Yin et autres

High Resolution Image Download MS PowerPoint Slide Small cell lung cancer (SCLC) is a neuroendocrine tumor with a high degree of malignancy. Due to limited treatment options, patients with SCLC have a poor prognosis. We have found, however, that intravenously administered octreotide …

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