Accès ouvert
2026
article
OpenAlex
Anqing Yan, Jiajia Zhang, Jin Yao, Shanshan Qin et autres
Targeted alpha therapy (TAT) has emerged as a highly potent modality in precision oncology. However, its clinical translation is hindered by unique radiobiological and pharmacological challenges. This review provides a structured overview of carrier systems used in TAT, including small molecules, peptides, …
cn
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Accès ouvert
2026
article
OpenAlex
Kaitao Wang, Han Zhang, Jiajia Zhang, S H I K A I Yu et autres
Ischemia with non-obstructive coronary artery disease (INOCA) is frequently driven by coronary microvascular dysfunction (CMD) but remains difficult to diagnose using conventional angiography alone. A 69-year-old female presented with typical chest pain. Coronary angiography (CAG) revealed no stenosis ≥ 50%, with slow …
cn
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Accès ouvert
2025
article
OpenAlex
Zhiling Song, Jiajia Zhang, Shanshan Qin, Xiaohui Luan et autres
Targeted alpha therapy (TAT) has emerged as a promising radiopharmaceutical modality in precision oncology. Compared to beta-emitters, alpha-emitters exhibit superior properties, including higher linear energy transfer, shorter penetration range, enhanced resistance to hypoxic conditions, and convenient radiation protection. Notably, alpha-emitters also demonstrate …
cn
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Accès ouvert
2025
article
OpenAlex
Jiajia Zhang, Shanshan Qin, Xuhao Huang, Erina Hilmayanti et autres
The aim of this study is to overcome the challenges of poor tumor penetration and systemic toxicity in targeted alpha therapy (TAT) while also evaluating its immunomodulatory effects to enhance antitumor immune responses in melanoma treatment. This study developed a 211 At-labeled …
cn, jp
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2024
article
OpenAlex
Mengdie Yang, Jianguo Li, Xiaohui Luan, Xiaoyi Zhang et autres
Abstract Targeted Alpha therapy (TAT) has promising application prospects in tumor therapy. It is very appealing to design alpha‐emitting radiopharmaceuticals that can modulate the immune microenvironment to overcome the limitations of immunotherapy. Herein, Mg/Al layered double hydroxide nanomaterials (LDH) are utilized to …
cn
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Accès ouvert
2024
article
OpenAlex
Jingfeng Zhang, Yachao Liu, Xiaohui Luan, Huanhuan Liu et autres
Prostate-specific membrane antigen positron emission tomography (PSMA-PET) guided targeted biopsy has shown potential for detecting more prostate cancer (PCa) cases. However, relying exclusively on imaging may risk missing lesions, an issue that could be addressed by incorporating radiation-guided technology. Accordingly, we aimed …
cn
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Accès ouvert
2024
article
OpenAlex
Xiaohui Luan, Shaoxi Niu, Yachao Liu, Xiaojun Zhang et autres
Abstract Purpose PSMA/PET has been increasingly used to detect PCa, and PSMA/PET-guided biopsy has shown promising results. However, it cannot be confirmed immediately whether the tissues are the targeted area. In this study, we aimed to develop a novel probe, [123I]I-PSMA-7. First, …
cn
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Accès ouvert
2023
article
OpenAlex
Can Li, Yanliang Dong, Yue Pan, Yun Han et autres
Background: F]FDG PET} parameters in predicting outcomes for patients with GBA. Methods: F]FDG PET/computed tomography (CT) before treatment were retrospectively analyzed at Chinese PLA General Hospital from January 2012 to June 2022. All patients were diagnosed by pathology, and their baseline characteristics …
cn
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Accès ouvert
2023
article
OpenAlex
Guanyun Wang, Lei Du, Xia Lu, Shengxin Chen et autres
Background: 18F-fluorodeoxyglucose positron emission tomography-computerized tomography (18F-FDG PET-CT) has demonstrated high sensitivity in the diagnosis of autoimmune pancreatitis (AIP) and pancreatic ductal adenocarcinoma (PDAC), while also exhibiting the ability to distinguish AIP from PDAC lesions. The objective of this investigation was to …
cn
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Accès ouvert
2023
erratum
OpenAlex
Guanyun Wang, Wen‐Wen Zhang, Xiaohui Luan, Zhanbo Wang et autres
The original version of this article has been updated.In the published article, there was a mistake in the Funding statement. The funding statement for the Key Development Project of the Department of Science and Technology was displayed as "2015CBd051". The correct statement …
cn
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Accès ouvert
2023
article
OpenAlex
Guanyun Wang, Wenwen Zhang, Xiaohui Luan, Zhanbo Wang et autres
Purpose To investigate the diagnostic value of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET), as an imaging biomarker, for predicting pathological response and prognosis of unresectable hepatocellular carcinoma (HCC) patients treated with Lenvatinib and programmed cell death protein 1 (PD-1) inhibitors as a …
cn
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Accès ouvert
2023
article
OpenAlex
Can Li, Xiaohui Luan, Xiao Bi, Shengxin Chen et autres
Abstract Objective To evaluate the diagnostic value of a multiparameter model based on 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) metabolic parameters and clinical variables in differentiating nonmetastatic gallbladder cancer (GBC) from cholecystitis. Patients and methods In total, 122 patients (88 GBC nonmetastatic …
cn
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