Targeted alpha therapy: a comprehensive analysis of the biological effects from “local-regional-systemic” dimensions

Le résumé fourni par la source

Targeted alpha therapy (TAT) has emerged as a promising radiopharmaceutical modality in precision oncology. Compared to beta-emitters, alpha-emitters exhibit superior properties, including higher linear energy transfer, shorter penetration range, enhanced resistance to hypoxic conditions, and convenient radiation protection. Notably, alpha-emitters also demonstrate therapeutic efficacy against a subset of tumors exhibiting resistance to beta-radiotherapy. In 2013, the first α-particle therapeutic agent, ²²³RaCl₂ (Xofigo®), was approved by the FDA for treating bone metastases in advanced castration-resistant prostate cancer, marking a milestone in clinical translation of alpha-emitters. However, the biological mechanisms underlying alpha-particle-mediated therapeutic effects remain incompletely elucidated, which has hindered the optimization of precision treatment strategies. This review systematically analyzes TAT’s tripartite antitumor mechanisms—targeted effects, bystander effects and abscopal effects—thereby constructing a “local-regional-systemic” multidimensional antitumor network. This framework not only clarifies the radiobiological principles of α-emitters but also provides innovative perspectives for advancing TAT applications in tumor precision therapy.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.