John P. Grimble

AI-Assisted OCT Imaging for Core Needle Biopsy Guidance: The 1st in Humans Study

Nicusor V. Iftimia, Poonam Yadav, Michael Primrose, Gopi N. Maguluri et autres

Background: The heterogeneous nature of cancer with varying degrees of fat, necrosis, fibrosis, and varying degrees of tissue repair severely impacts the success of acquiring adequate tissue samples during percutaneous image-guided biopsy. Although ultrasound or CT fluoroscopy are used to identify tumor …

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The first in human optical biopsy study using linear encoding optical coherence tomography imaging (OCT)

Jack Jones, Michael Primrose, Gopi N. Maguluri, John P. Grimble et autres

Clinical Validation of a Novel Robotic Device for MR-guided Prostate Biopsy: Initial Patient Experience

Pedro Moreira, Mariana C. Bernardes, John P. Grimble, Kemal Tuncali et autres

Magnetic resonance imaging (MRI)-guided transperineal targeted prostate biopsy has potential to provide precise cancer diagnosis. However, it is challenged by targeting errors and needle deflection. The main issue is that the traditional needle guides have limited degrees of freedom (DoF) and therefore …

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In vivo assessment of airway wall compliance during inhalation injury response using anatomical optical coherence elastography

Nicusor V. Iftimia, Srikamal Soundararajan, Scott H. Randell, Yinghan Xu et autres

Significance: Inhalation injury, a critical complication in patients with severe burns, contributes substantially to morbidity and mortality. Current diagnostic practices suffer from subjectivity and lack quantitative metrics. Enhanced diagnostic accuracy is imperative for improving treatment outcomes. Aim: Our objective was to develop …

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Combined Reflectance Confocal Microscopy–Optical Coherence Tomography for Skin Cancer Detection and Therapy Guidance

Nicusor V. Iftimia, John P. Grimble, Gopi N. Maguluri, Aditi Sahu et autres

This chapter presents recent efforts at Physical Sciences Inc. (PSI), Andover, MA, to develop and clinically translate a novel optical imaging technology for skin cancer diagnosis and therapy guidance. This technology is based on combined use of optical coherence tomography (OCT) and …

In vivo assessment of airway wall compliance during inhalation injury response using anatomical optical coherence elastography

Yinghan Xu, Srikamal Soundararajan, Scott H. Randell, Nicusor V. Iftimia et autres

SignificanceInhalation injury, a critical complication in patients with severe burns, contributes substantially to morbidity and mortality. Current diagnostic practices suffer from subjectivity and lack quantitative metrics. Enhanced diagnostic accuracy is imperative for improving treatment outcomes.AimOur objective was to develop normalized cross-sectional compliance …

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Core needle biopsy guidance using deep-learning assisted OCT imaging (Conference Presentation)

Shelley H Zhang, Michael Primrose, Gopi N. Maguluri, John P. Grimble et autres

This study presents a portable optical coherence tomography imaging system that provides intraprocedural feedback on the precise selection of the biopsy location. It uses a hand-held optical imaging probe supported by imaging processing pipeline based on deep learning neural networks. The preliminary …

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Guiding epidurals with optical feedback (Conference Presentation)

Gui-fang Zhu, HuaLei Zhang, John P. Grimble, Gopi N. Maguluri et autres

We present a novel low coherence interferometry/fiber Bragg sensing technology for guiding difficult cases of epidurals. The results of an animal study will be presented to demonstrate the suitability of the technology for further in vivo human testing.

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Motorized template for MRI-guided focal cryoablation of prostate cancer

Pedro Lopes Da Frota Moreira, John P. Grimble, Mariana C. Bernardes, Nick Iftimia et autres

MR-guided focal cryoablation of prostate cancer has often been selected as a minimally-invasive treatment option. Placing multiple cryo-needles accurately to form an ablation volume that adequately covers the target volume is crucial for a better oncological/functional outcome. This work presents an MRI-compatible …

Assessing Lung Fibrosis with ML-Assisted Minimally Invasive OCT Imaging

R. B. Steinberg, Jack Meehan, Doran Tavrow, Gopi N. Maguluri et autres

This paper presents a combined optical coherence tomography (OCT) imaging/machine learning (ML) technique for real-time analysis of lung tissue morphology to determine the presence and level of invasiveness of idiopathic lung fibrosis (ILF). This is an important clinical problem as misdiagnosis is …

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Smart sensor for guiding safe delivery of anesthetic and pain drugs through epidurals

Ge Zhu, John P. Grimble, Gopi N. Maguluri, Nicusor V. Iftimia

A smart optical probe that enables in vivo tissue type identification and the measurement of the force applied to the needle during epidural procedures is presented. This probe is meant to reduce the adverse risk associated with needle misplacement. It combines a …

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High Sensitivity Singlet Oxygen Luminescence Sensor Using Computational Spectroscopy and Solid-State Detector

Tiffany C. Yu, Steve J. Davis, Mark T. Scimone, John P. Grimble et autres

This paper presents a technique for high sensitivity measurement of singlet oxygen luminescence generated during photodynamic therapy (PDT) and ultraviolet (UV) irradiation on skin. The high measurement sensitivity is achieved by using a computational spectroscopy (CS) approach that provides improved photon detection …

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