Mark T. Scimone

Targeting cargo to an unconventional secretory system within megakaryocytes allows the release of transgenic proteins from platelets

Nathan L. Asquith, Isabelle C. Becker, Mark T. Scimone, Thais Boccia et autres

us (code pays fourni par la source)

High Sensitivity Singlet Oxygen Luminescence Sensor Using Computational Spectroscopy and Solid-State Detector

Tiffany C. Yu, Steve J. Davis, Mark T. Scimone, John P. Grimble et autres

This paper presents a technique for high sensitivity measurement of singlet oxygen luminescence generated during photodynamic therapy (PDT) and ultraviolet (UV) irradiation on skin. The high measurement sensitivity is achieved by using a computational spectroscopy (CS) approach that provides improved photon detection …

us (code pays fourni par la source)

Surgical margins analysis with combined confocal microscopy-optical coherence tomography

Nicusor V. Iftimia, John P. Grimble, Mark T. Scimone, Gopi N. Maguluri et autres

Successful cancer surgery is achieved when the surgical bed is clear of cancer cells. The standard method to make this determination is to analyze the margins of the excised surgical specimen. Currently, frozen-section analysis (FSA) is the typical procedure for analyzing tissue …

us (code pays fourni par la source)

Neural cell injury pathology due to high-rate mechanical loading

Jonathan B. Estrada, Harry C. Cramer, Mark T. Scimone, Selda Buyukozturk et autres

Abstract Successful detection and prevention of brain injuries relies on the quantitative identification of cellular injury thresholds associated with the underlying pathology. Here, by combining a recently developed inertial microcavitation rheology technique with a 3D in vitro neural tissue model, we quantify …

us (code pays fourni par la source)

Low-cost time-gated imager for intraoperative nerve identification

Mark T. Scimone, Youbo Zhao, Jason R. Gunn, Brian W. Pogue et autres

Intraoperative nerve recognition is critical to avoid accidental transection. Fluorescence-guided surgery can aid in nerve identification. However, detection of weak nerve-specific fluorescence signal is susceptible to the interference from high-background bright lights. We present a time-gated imager designed with ease-of-use and cost …

us (code pays fourni par la source)

Assessment of breast cancer surgical margins with multimodal optical microscopy: A feasibility clinical study

Mark T. Scimone, Savitri Krishnamurthy, Gopi N. Maguluri, Dorin V. Preda et autres

Providing surgical margin information during breast cancer surgery is crucial for the success of the procedure. The margin is defined as the distance from the tumor to the cut surface of the resection specimen. The consensus among surgeons and radiation oncologists is …

us (code pays fourni par la source)

Neural cell injury pathology due to high-rate mechanical loading

Jonathan B. Estrada, Harry C. Cramer, Mark T. Scimone, Selda Buyukozturk et autres

Successful detection and prevention of brain injuries relies on the quantitative identification of cellular injury thresholds associated with the underlying pathology. Here, by combining a recently developed inertial microcavitation rheology technique with a 3D in vitro neural tissue model, we quantify and …

us (code pays fourni par la source)

Application of mild hypothermia successfully mitigates neural injury in a 3D in-vitro model of traumatic brain injury

Mark T. Scimone, Harry C. Cramer, Paul Nathan Hopkins, Jonathan B. Estrada et autres

Therapeutic hypothermia (TH) is an attractive target for mild traumatic brain injury (mTBI) treatment, yet significant gaps in our mechanistic understanding of TH, especially at the cellular level, remain and need to be addressed for significant forward progress to be made. Using …

us (code pays fourni par la source)

Low cost hand scanning OCT probe for biopsy guidance (Conference Presentation)

Gopi N. Maguluri, Mark T. Scimone, Jesung Park, John P. Grimble et autres

We report the development and the pre-clinical testing of a manual scanning OCT-based probe for core needle biopsy guidance. While stereotactic radiography, ultrasound, computed tomography, and magnetic resonance imaging are used to guide needle placement within a tumor, the optical probe provides …

us (code pays fourni par la source)

Automated analysis of tissue heterogeneity based on OCT images for improving personalized cancer therapy effectiveness (Conference Presentation)

Mark T. Scimone, Gopi N. Maguluri, Jesung Park, Nicusor V. Iftimia

In the current era of personalized cancer therapy, various drugs need to be rapidly tested to determine their efficacy in killing cancer cells. In this way, the most effective drug can be administered to improve therapy effectiveness. However, since the biopsy specimens …

us (code pays fourni par la source)

Multimodal imaging microscope for intraoperative detection of breast tumors positive margins (Conference Presentation)

Mark T. Scimone, Gopi N. Maguluri, Jesung Park, John P. Grimble et autres

Identification of positive margins during breast cancer conserving surgery is crucial for successful tumor resection. To address this clinical need, we developed a microscope that combines fluorescent microscopy, optical coherence tomography (OCT), and reflectance confocal microscopy (RCM) to identify the presence of …

us (code pays fourni par la source)

Mild hypothermia mitigates neural injury in a 3D in-vitro model of mTBI

Mark T. Scimone, Harry C. Cramer, Paul Hopkins, Jonathan B. Estrada et autres

Therapeutic hypothermia (TH) is an attractive target for mild traumatic brain injury (mTBI) treatment, yet significant gaps in our mechanistic understanding of TH, especially at the cellular level, remain and need to be addressed for significant forward progress to be made. Using …