Faouzi Souala

Immunovirological status in people with perinatal and adult-acquired HIV-1 infection: a multi-cohort analysis from France

Rémonie Seng, Pierre Frange, Albert Faye, Catherine Dollfus et autres

Background: No study has compared the virological and immunological status of young people with perinatally-acquired HIV infection (P-HIV) with that of people with HIV adulthood (A-HIV) having a similar duration of infection. Methods: 5 French cohorts of P-HIV and A-HIV patients with …

fr, be, Cameroun (code pays fourni par la source)

Proportion of APOBEC3-induced defective HIV DNA after 1 year of dolutegravir + lamivudine simplification in the ANRS 167 LAMIDOL trial

Fella Mazouz, Mélanie Bertine, Romain Coppée, Alexandre Storto et autres

BACKGROUND: Hypermutated viruses induced by APOBEC3 (apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3) proteins comprise some of the defective viruses in the HIV reservoir. Here, we assessed the proportion of APOBEC3-induced defective proviruses in HIV-positive patients before and after receiving dolutegravir + lamivudine …

fr, mq (code pays fourni par la source)

Drastic Reduction in Time to Controlled Viral Load in People With Human Immunodeficiency Virus in France, 2009–2019: A Longitudinal Cohort Study

Lise Cuzin, Adeline Morisot, Clotilde Allavena, France Lert et autres

BACKGROUND: Aspirational targets to end AIDS by 2030 include having 95% of people with human immunodeficiency virus (HIV; PWH) diagnosed, 95% treated, and 95% with controlled viral load (VL). Our objective was to describe, using a large French prospective cohort, the median …

fr, mq, gp (code pays fourni par la source)

Low-level viral loads and virological failure in the integrase strand transfer era

Lise Cuzin, Philippe Flandre, Clotilde Allavena, Romain Palich et autres

OBJECTIVES: To analyse the occurrence of virological failure (VF) in patients starting ART with an integrase strand transfer inhibitor (INSTI)-based regimen in recent years, in relation with previous episodes of low-level viral load (LLVL). PATIENTS AND METHODS: Patients starting a first ART …

fr, mq (code pays fourni par la source)

In-Depth Characterization of Full-Length Archived Viral Genomes after Nine Years of Posttreatment HIV Control

Pauline Trémeaux, Frédéric Lemoine, Adeline Mélard, Marine Gousset et autres

Most people living with HIV need antiretroviral therapy to control their infection and experience viral relapse in case of treatment interruption, because of viral reservoir (proviruses) persistence. Knowing that proviruses are very diverse and most of them are defective in treated individuals, …

fr (code pays fourni par la source)

Acute hepatitis B virus infection despite vaccination in a patient treated by infliximab: a case report

Juliette Besombes, Faouzi Souala, Guillaume Bouguen, Dominique Guyader et autres

BACKGROUND: Despite an effective vaccine, hepatitis B remains a major global health problem due to its significant morbidity and mortality. Vaccination in immunosuppressed patients such as those treated for an inflammatory bowel disease (IBD) can be less effective. This case describes an …

fr (code pays fourni par la source)

A highly virulent variant of HIV-1 circulating in the Netherlands

Chris Wymant, Daniela Bezemer, François Blanquart, Luca Ferretti et autres

increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical …

gb, nl, fr, se, de, ch, us, fi (code pays fourni par la source)

Dolutegravir-based dual maintenance regimens combined with lamivudine/emtricitabine or rilpivirine: risk of virological failure in a real-life setting

Colin Deschanvres, Jacques Reynes, Isabelle Lamaury, David Rey et autres

BACKGROUND: Maintenance ART with dolutegravir-based dual regimens have proved their efficacy among HIV-1-infected subjects in randomized trials. However, real-life data are scarce, with limited populations and follow-up. OBJECTIVES: We assessed virological failure (VF) and resistance-associated mutations (RAMs) on dolutegravir maintenance regimens in …

fr, gp, mq (code pays fourni par la source)

Microelimination or Not? The Changing Epidemiology of Human Immunodeficiency Virus-Hepatitis C Virus Coinfection in France 2012–2018

Laurent Cotte, Laurent Hocqueloux, Maeva Lefebvre, Pierre François Pradat et autres

BACKGROUND: The arrival of highly effective, well-tolerated, direct-acting antiviral agents (DAA) led to a dramatic decrease in hepatitis C virus (HCV) prevalence. Human immunodeficiency virus (HIV)-HCV-coinfected patients are deemed a priority population for HCV elimination, while a rise in recently acquired HCV …

fr, mq (code pays fourni par la source)

Awareness of Chlamydia trachomatis infection by people attending a sexual transmitted infection (STI) clinic and missed opportunities for screening in a primary health care setting

C. Pépin, Faouzi Souala, Edited By, M. Bérar et autres

fr (code pays fourni par la source)

Utility of hyposmia and hypogeusia for the diagnosis of COVID-19

François Bénézit, Paul Le Turnier, Charles Declerck, Cécile Paillé et autres

fr, ca, vn (code pays fourni par la source)

Enhanced immunovirological response in women compared to men after antiretroviral therapy initiation during acute and early HIV‐1 infection: results from a longitudinal study in the French ANRS Primo cohort

Sophie Novelli, Pierre Delobel, Olivier Bouchaud, Véronique Avettand-Fènoël et autres

Abstract Introduction Previous studies have reported better immunovirological characteristics in women compared with men after HIV seroconversion. We investigated whether differences persisted under long‐term antiretroviral therapy (ART) in individuals treated since acute and early HIV‐1 infection (AHI). Methods Data were obtained for …

fr, mq (code pays fourni par la source)