Accès ouvert déclaré
2024
article
Immunovirological status in people with perinatal and adult-acquired HIV-1 infection: a multi-cohort analysis from France
Rémonie Seng, Pierre Frange, Albert Faye, Catherine Dollfus, Jérôme Le Chenadec, Faroudy Boufassa, Asma Essat, Tessa Goetghebuer, Elisa Arezes, Véronique Avettand-Fènoël, Jean-Joël Bigna, Stéphane Blanche, Cécile Goujard, Laurence Meyer, Josiane Warszawski, Jean‐Paul Viard, Hugues Aumaître, Eric Froguel, Fabienne Caby, S. Dellion, Laurence Gérard, F. Lucht, C. Chirouze, M. Dupon, J.L. Schmit, Thierry Allègre, B. Cazenave, Gilles Hittinger, P. de Truchis, Johann Cailhol, C. Duvivier, Ana Canestri, Marina Karmochkine, Dominique Salmon‐Céron, David Zucman, Pierre Marie Girard, Claire Pintado, André Cabie, V. Rabier, Philippe Morlat, D. Neau, Claire Genet, S Bregigeon Ronot, Jade Ghosn, V. Reliquet, Philippe Van de Perre, J-L Pellegrin, C. Arvieux, Louis Bernard, Pierre Delobel, Lionel Piroth, F. Ajana, S Bevilacqua, Yasmine Debab, Anne‐Lise Lecapitaine, Laurent Cotte, S. Mokhtari, P. Mercié, P. Poubeau, Valérie Garrait, M.-A. Khuong, Geneviève Beck-Wirth, L. Blum, Franck Boccara, Thiérry Prazuck, Claudine Barbuat, J.-P. Viard, S. Stegmann-Planchard, Benoît Martha, Jean‐Marc Tréluyer, Éric Doré, C. Gaud, Eduardo de Oliveira Fernandes, Hikombo Hitoto, A. Compagnucci, Narcisse Elenga, Michael A. Levine, Sandrine Anne Martha, Corinne Floch-Tudal, Kamila Kébaïli, J Tricoire, Françoise Mazingue, Pascal Bolot, Patricia Brazille, Anne-Françoise Gennotte, Dirk van der Linden, Verônica Schmitz, Michel Moutschen, Catherine Crenn‐Hébert, F. Habibi, Anne Coursol, Elodie Guesdon, Pierre‐François Ceccaldi, Moumita Paul, E. Pannier, Valérie Marcou, Christophe Elleau, Marcel Achkar, Marc-Olivier Vareil, Anne Chacé, Sophie Couderc, Cédric Routier, Marie‐Anne Bouldouyre, Lise Selleret, Amélie Chabrol, Chahrazede Bellahcene, Claire Pluchart, A. Yangui, Dorothée Vignes, A. Alissa, Margaret Johnson, Eric Lachassinne, Amélie Benbara, Lamis R. Karaoui, A. Bongain, B. Yakeu, L. Cravello, C. Hubert, Philippe Faucher, D. Pinquier, Claire Borie, Daniele De Rocchi, Cécile Brunet-Cartier, Claire Briandet, J. Brouard, A Chalvon-Demersay, M. Rajguru, Kareen Billiemaz, A. Frésard, Anne Marie Moulin, Laurent Mesnard, Emmy Ε. Werner, E. Vintejoux, Jaime Marian, S. Ranaivojaona, François Bissuel, Mohamed Abdelhadi, Yamina Hammou, C Genet-Villeger, Yves Hatchuel, Gastón Bachelard, M. Médus, Julie Nguyen, Thomas Guimard, A. Martha, Mahfoud Rouha, Pascale Perfezou, Luc de Saint Martin, S. Jaffuel, Rodolphe Buzelé, Marie Gousseff, Corinne Cudeville, Virginie Vitrat, Christophe Michau, Gilles Palenzuela, Martin Drießen, Brigitte Heller-Roussin, Jean-Marc Labaune, Blandine Muanza, Djamila Makhloufi, Jérôme Massardier, M Partisani, Isabelle Hau, C. Runel-Belliard, Camille Bréhin, M. Lalande, M. Lagrée, Karine Lacombe, Jean‐Michel Molina, Jacques Reynes, Olivier Robineau, François Raffi, Agathe Becker, Laurence Weiss, Gilles Pialoux, Faouzi Souala, A. Rami, C. Katlama, Frédéric Bastides, Catherine Michel, D. Salmon, J-D Le Lièvre, Albert Sotto, É. Rouveix, A. Naqvi, Sylvie Brégigeon, R. Rodet, A. Simon-Coutelier, J.-L. Esnault, Andréas Stein, C. Godin-Colet, G. Pichancourt, Pauline Caraux-Paz, M. Mohseni Zadeh, C. Lascaux-Cametz, L. Bodard, Jean‐Luc Pellegrin, N. Ettahar, Agnès Uludag, Éric Rosenthal, Françoise Clary, Stéphane Jauréguiberry, Patrick Philibert, E. Chakvetadze, H. Champagne, V. Daneluzzi, Jeanne Goupil de Bouillé, A. Leprêtre, I. Lamaury, Iuliana Darasteanu, Bruno Abraham, D. Garipuy, J L Berger, Kadiatou Diallo, F. Gourdon, O. Vaillant, Valérie Gaborieau, J. Doll, D. Quinsat, L. Geffray, J. Girard, D. Houlbert, V. Perronne, Elise Klement-Frutos, O. Antioniotti, C. Rouzioux, Olivier Lortholary, S. Boucly, Aurélie Maignan, Rodolphe Thiébaut, Marie‐Aline Charles, Rosemary Dray‐Spira, Camille Legeai, Vera S. C. Amon, N. Benammar, R. Seng, Laurence Slama, Philippe Bonnard, Catherine Chakvetadze, Thomas L’Yavanc, Jacqueline Capeau, C. Vigouroux, Soraya Fellahi, J.‐P. Bastard, Éric Oksenhendler, J.F. Bourge, Véronique Bajzik, D. Séréni, Caroline Lascoux‐Combe, Olivier Tauléra, Le Van Dien, Jean-Paul Delgado, T Saint-Marc, Samuel Ferret, J. Pavie, Jean‐François Bergmann, Maguy Parrinello, Cherif Boudraa, Boubacar Diallo, Catherine Lupin, S. Herson, Anne Simon, Nadia Edeb, Loı̈c Guillevin, Tassadit Tahi, M P Pietri, D. Tisne-Dessus, C. Jalbert, P. Yéni, Sophie Matheron, Golriz Pahlavan, Bao-Chau Phung, N. Talbi, Z. Ramani, Glenn Catalano, C. Godard, François Boué, V. Chambrin, Dominique Bornarel, H. O. Schoen, R. Carlier, B. Fantin, Christine Svinth-Værge Põder, R. Dhôte, M. Bentata, P. Honoré, Olivier Bouchaud, Xuan Tuyet, Jean‐François Delfraissy, F. Chaix, Marie‐Thérèse Rannou, Yaniv Levy, A Sobel, C. Dumont, Sylvie Abel, S. Pierre-François, V. Beaujolais, I. Poizot-Martin, Olivia Zaegel‐Faucher, C. Debreux, J.F. Moreau, E. Van Der Gheynst, M.C. Thiebaut-Drobacheff, Adeline Foltzer, Bruno Hoën, Jean‐François Faucher, M.H. Gil, J.M. Ragnaud, I. Raymond, I. Louis, Mojgan Hessamfar, Vincent Baillat, Corinne Merle De Boever, Christine Tramoni, A. Soufflet, P. Guadagnin, P. Choutet, O. Mounoury, D. Brosseau, H Hüe, T. May, S. Wassoumbou, Molly Stenzel, M P Bouillon, Yazdan Yazdanpanah, T. Huleux, E Aïssi, S. Pavel, D. Rey, Geneviève Chêne, P Fischer, M. Martinot, Anne Pachart, François Jeanblanc, J.L. Touraine, C. Trépo, P. Miailhes, K. Kouadjo, V. Thoirain, C. Brochier, S Léautez, Isabelle Suaud
2Citations signalées — pas une note de qualité
15Institutions déclarées
3Pays d’affiliation déclarés
Résumé fourni par la source
Background: No study has compared the virological and immunological status of young people with perinatally-acquired HIV infection (P-HIV) with that of people with HIV adulthood (A-HIV) having a similar duration of infection. Methods: 5 French cohorts of P-HIV and A-HIV patients with a known date of HIV-infection and receiving antiretroviral treatment (ART), were used to compare the following proportions of: virological failure (VF) defined as plasma HIV RNA ≥ 50 copies/mL, CD4 cell percentages and CD4:CD8 ratios, at the time of the most recent visit since 2012. The analysis was stratified on time since infection, and multivariate models were adjusted for demographics and treatment history. Findings: 310 P-HIV were compared to 1515 A-HIV (median current ages 20.9 [IQR:14.4-25.5] and 45.9 [IQR:37.9-53.5] respectively). VF at the time of the most recent evaluation was significantly higher among P-HIV (22.6%, 69/306) than A-HIV (3.3%, 50/1514); p ≤ 0.0001. The risk of VF was particularly high among the youngest children (2-5 years), adolescents (13-17 years) and young adults (18-24 years), compared to A-HIV with a similar duration of infection: adjusted Odds-Ratio (aOR) 7.0 [95% CI: 1.7; 30.0], 11.4 [4.2; 31.2] and 3.3 [1.0; 10.8] respectively. The level of CD4 cell percentages did not differ between P-HIV and A-HIV. P-HIV aged 6-12 and 13-17 were more likely than A-HIV to have a CD4:CD8 ratio ≥ 1: 84.1% vs. 58.8% (aOR = 3.5 [1.5; 8.3]), and 60.9% vs. 54.7% (aOR = 1.9 [0.9; 4.2]) respectively. Interpretation: P-HIV were at a higher risk of VF than A-HIV with a similar duration of infection, even after adjusting for treatment history, whereas they were not at a higher risk of immunological impairment. Exposure to viral replication among young patients living with HIV since birth or a very early age, probably because of lower adherence, could have an impact on health, raising major concerns about the selection of resistance mutations and the risk of HIV transmission. Funding: Inserm - ANRS MIE.
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Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Immunovirological status in people with perinatal and adult-acquired HIV-1 infection: a multi-cohort analysis from France
- Date Crossref
- 01/05/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
HIV Research and TreatmentHIV/AIDS Research and InterventionsHIV-related health complications and treatments