2023
article
Low-level viral loads and virological failure in the integrase strand transfer era
Lise Cuzin, Philippe Flandre, Clotilde Allavena, Romain Palich, Claudine Duvivier, Agathe Becker, Hélène Laroche, P Pugliese, André Cabie, C Chirouze, O Babre, Kévin Bouiller, F Bozon, A-S Brunel, É. Chevalier, Laurent Hustache‐Mathieu, J Lagoutte, Quentin Lepiller, S Marty-Quinternet, Patrice Muret, B. Rosolen, Nadine Tissot, S. Jaffuel, Christine Jacomet, C. Auméran, Olivier Baud, A Brebion, V. Corbin, E Goncalvez, Cécile Henquell, H. Laurichesse, O. Lesens, D Mazzocolin, Audrey Mirand, Natacha Mrozek, Cathrin Theis, M. Vidal, I. Lamaury, François Bissuel, F Boulard, Elodie Curlier, Isabelle Fabre, E Halley, Cécile Herrmann‐Storck, C. Le Guillou, Samuel Markowicz, Magda Marquet, Rachida Ouissa, M. C. Receveur, J Reltien, P.-M. Roger, B. Tressières, Dominique Merrien, O Bollangier, D Boucher, Thomas Guimard, L Laine, S Léautez, Marine Morrier, P Perré, P Point, Jean‐François Faucher, A. Cypierre, S. Ducroix-Roubertou, H. Durox, C Genet-Villeger, J.C. Pascual, P. Pinet, Jean‐Baptiste Woillard, L Cotte, Florence Ader, Dulce Alfaiate, A. Boibieux, Céline Brochier‐Armanet, Florence Brunel-Dalmas, O Cannesson, Pierre Chiarello, Christian Chidiac, Anne Conrad, S Degroodt, Tristan Ferry, Matthieu Godinot, V. Icard, J M Livrozet, Djamila Makhloufi, T. Perpoint, M. Perry, Cécile Pouderoux, Stanzi M. le Roux, Mary‐Anne Trabaud, Claire Triffault-Fillit, Florent Valour, Isabelle Ravaux, A. Ménard, Sarah Aherfi, Sophie Amrane, A Y Belkhir, Philippe Colson, C Dhiver, M Martin-Degioanni, Line Meddeb, Malika Mokhtarı, Anne Motte, Hervé Tissot‐Dupont, Christelle Tomei, I Poizot-Martin, Sylvie Brégigeon, M J Ducassou, S Galie, A Ivanova, I Jaquet, V. Obry‐Roguet, M Orticoni, E. Ressiot, A S Ritleng, T Rojas-Rojas, Olivia Zaegel‐Faucher, Sylvie Abel, J Bavay, B Bigeard, Ornella Cabras, R Dupin de Majoubert, Laurence Fagour, K Guitteaud, Mélanie Lehoux, Clementine Montagnac, S. Pierre-François, Katherine De Rome, J M Turmel, Jacques Reynes, N. Atoui, M Bistoquet, Éric Delaporte, Vincent Le Moing, J.-P. Lejeune, Alain Makinson, N Meftah, Corinne Merle De Boever, Brigitte Montès, Ana Ferrer, Édouard Tuaillon, Benjamin Lefèvre, Marie André, G Baronnet, S Bevilacqua, L. Boyer, M P Bouillon, Alexandre Charmillon, M Delestan, E. Frentiu, François Goehringer, Sandrine Hénard, Eliette Jeanmaire, Christian Rabaud, A Radjabaly-Mandjee, F. Raffi, Antoine Asquier-Khati, Éric Billaud, Charlotte Biron, B. Bonnet, Sabelline Bouchez, David Boutoille, Cécile Brunet-Cartier, M Cavellec, Colin Deschanvres, Virginie Ferré, Benjamin Gaborit, A Grégoire, Matthieu Grégoire, T Jovelin, M. Lefèbvre, R. Lecomte, R Mahot, P Morineau, E. Paredes, Véronique Reliquet, Solène Sécher, A Soria, S Bréaud, Matthieu Buscot, M Carles, David Chirio, Éric Cua, P. Dellamonica, Élisa Demonchy, Anne De Monte, J. Durant, Stephen J. Ferrando, R. Garraffo, C Michelangeli, A. Naqvi, I. Perbost, C Pradier, B Prouvost-Keller, Karine Risso, Isabelle Touitou, A Viot, S Wehrlen-Pugliese, Laurent Hocqueloux, C. Gubavu, Vincent Legros, F Peira, Thiérry Prazuck, V Rzepecki, Aymeric Sève, Antoine Chéret, Aurélie Barrail‐Tran, Á. Castro, R Colarino, Cécile Goujard, Stéphane Jauréguiberry, Yann Quertainmont, Elina Teicher, Véronique Joly, Charlotte Charpentier, Diane Descamps, M Digumber, A. Gervais, Jade Ghosn, Zélie Julia, Roland Landman, Sylvie Lariven, Sylvie Le Gac, Françoise Louni, Gilles Peytavin, C. Rioux, Yazdan Yazdanpanah, Karima Amazzough, Ghania Benabdelmoumen, P Bossi, G Cessot, Caroline Charlier, Paul‐Henri Consigny, E Gomes-Pires, Kaoutar Jidar, Emmanuel Lafont, Fanny Lanternier, Olivier Lortholary, J Lourenco, Cléa Melenotte, Perrine Parize, Anne Pouvaret, C. Rouzaud, Alexandra Serris, F. Touam, Christine Katlama, Rachid Agher, Yasmine Dudoit, N Hamani, N Qatib, I Qzaibri, L Lenclume, L Schneider, Sophie Seang, Roland Tubiana, M. A. Valantin, Firouzé Bani‐Sadr, J L Berger, Sophie Demotier, Maxime Hentzien, Gilles Julien, I Kmiec, D Lambert, H Marty, Yohan N’Guyen, Juliette Romaru, C. Arvieux, M. Baldeyrou, François Bénézit, J.-M. Chapplain, Magali Dupont, J C Duthé, A Lebot, F. Lemaı̂tre, Anne Maillard, Clément Morlat, S. Patrat-Delon, M Poisson-Vannier, Charlotte Pronier, M Revest, J P Sinteff, Faouzi Souala, Pierre Tattevin, Amandine Gagneux‐Brunon, Élisabeth Botelho-Nevers, A. Frésard, F. Lucht, V Ronat, D. Rey, Geneviève Chêne, Claudine Bernard-Henry, E de Mautort, Samira Fafi‐Kremer, P Fischer, Pierre Gantner, C Mélounou, M Partisani, Pierre Delobel, Maria Alvarez, N Biezunski, Alexa Debard, Cyrille Delpierre, Camille Garnier, Géraldine Gaube, L Lelièvre, M Marcel, Guillaume Martin‐Blondel, M Piffaut, Lorena Porte, Karine Sauné, Olivier Robineau, E Aïssi, F. Ajana, I. Alcaraz, Enagnon Kazali Alidjinou, V. Baclet, Laurence Bocket, Anne Boucher, Vincent Derdour, Mark Gilbert, T. Huleux, B. Lafon-Desmurs, Agnès Meybeck, M Pradier, Macha Tétart, P. Thill, M. Valette, N. Viget, Grégory Corvaisier
9Citations signalées — pas une note de qualité
16Institutions déclarées
2Pays d’affiliation déclarés
Résumé fourni par la source
OBJECTIVES: To analyse the occurrence of virological failure (VF) in patients starting ART with an integrase strand transfer inhibitor (INSTI)-based regimen in recent years, in relation with previous episodes of low-level viral load (LLVL). PATIENTS AND METHODS: Patients starting a first ART between 1 January 2015 and 31 December 2020 based on two NRTIs and one INSTI were included if after virological control (two measures of VL < 50 copies/mL) they had a minimum of two additional VL measurements. Cox models adjusted for sex, age, acquisition group, hepatitis B or C coinfection, place of birth, year of ART initiation, CD4+ T cells and VL at ART initiation, duration of known HIV infection and of ART regimen were used to assess the association between the time to VF and the occurrence of LLVL. ART regimen was evaluated as time-varying covariate. RESULTS: LLVL was described in 13.7% and VF in 11% of the 3302 patients. LLVL was associated with VF [adjusted HR (aHR) 1.76, 95% CI 1.28-2.41], as well as age (aHR 0.97/year, 95% CI 0.96-0.98), CD4+ T cell count at ART initiation (aHR 0.93, 95% CI 0.87-0.98), heterosexual transmission (aHR 1.76, 95% CI 1.30-2.37) and being born abroad (aHR 1.50, 95% CI 1.17-1.93). CONCLUSIONS: LLVL was related to VF. Even in the absence of subsequent failure, LLV episodes have a cost. Thus any VL value above 50 copies/mL should lead to enhanced adherence counselling.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Low-level viral loads and virological failure in the integrase strand transfer era
- Date Crossref
- 06/03/2023
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
HIV/AIDS drug development and treatmentHIV/AIDS Research and InterventionsHIV Research and Treatment