Wenyi Zheng

TSPAN3 defines a distinct intracellular trafficking route to secretory multivesicular bodies

Jelle van den Bor, Misko L Bobeldijk, Christopher Arpad Zala, Cristina Trueba Sanchez et autres

Abstract Extracellular vesicles (EVs) comprise molecularly diverse populations generated through multiple membrane-trafficking pathways, yet the intracellular basis of this heterogeneity remains poorly understood. Here, we identify the EV-associated tetraspanin TSPAN3 as a marker of a secretory multivesicular body (MVB) population that is …

nl, se, cn (code pays fourni par la source)

Regulation and Evolution of Iron Oxide Nanoparticles by Flame Synthesis: A Systematic Study of Solvent and Oxygen Concentration Effects

Shanyu Li, Weiqi Chen, Qiuhan Cai, B Zhang et autres

Flame synthesis of metal oxide nanoparticles has garnered significant attention. This study employed diffusion flame to produce iron oxide (Fe2O3) nanoparticles. The effects of precursor solvents and oxygen concentrations on particle structure, morphology, size distribution, and lattice oxygen content were examined. A …

Regulation and Evolution of Iron Oxide Nanoparticles by Flame Synthesis: A Systematic Study of Solvent and Oxygen Concentration Effects

Shanyu Li, Weiqi Chen, Qiuhan Cai, B Zhang et autres

Flame synthesis of metal oxide nanoparticles has garnered significant attention. This study employed diffusion flame to produce iron oxide (Fe2O3) nanoparticles. The effects of precursor solvents and oxygen concentrations on particle structure, morphology, size distribution, and lattice oxygen content were examined. A …

Quantitative Assessment of shRNA Loading and Delivery Efficiency of Engineered Extracellular Vesicles

Julia Rädler, Giulia Corso, Omnia Elsharkasy, Noriyasu Kamei et autres

Abstract RNA interference (RNAi) therapeutics enable selective silencing of disease-associated genes. Yet, their clinical application remains largely confined to the liver due to extrahepatic delivery constraints of current platforms such as GalNAc conjugates and lipid nanoparticles. Extracellular vesicles (EVs) offer an attractive …

se, jp, cn, gb, mx (code pays fourni par la source)

Systemic Inflammation Modulates Clearance and Drives Extra‐Hepatic Distribution of Extracellular Vesicles

Светлана Ивановна Павлова, Doste R. Mamand, André Görgens, Antje Maria Zickler et autres

Extracellular vesicles (EVs) are promising vehicles for targeted therapeutic delivery, capable of encapsulating and transporting biomolecules to specific cells and tissues. Given that inflammation is central to many acute and chronic diseases, understanding EV biodistribution under inflammatory conditions is essential for therapeutic …

se, iq, be, gb, mx, jp (code pays fourni par la source)

Development of Endogenous Protein Probes for Characterizing Surface Proteins and Cellular Interactors of Extracellular Vesicles

Wenyi Zheng, Metoboroghene Oluwaseyi Mowoe, Wenqing Hou, Daniel W. Hagey et autres

Extracellular vesicle (EV) surface proteins, derived from producer cells and their surrounding environment, represent a valuable source of biomarkers and participate in a plethora of biological functions, including intercellular communication. However, current methods struggle to distinguish core EV surface proteins from adsorbed …

se, cn, jp (code pays fourni par la source)

Toward standardized outcome reporting in pneumonia: an overview of systematic reviews of antimicrobial therapy

Hong Mei Cao, Songsong Tan, Rui Zhang, Huaye Zhao et autres

cn, se (code pays fourni par la source)

CAP1-Mediated m6A Modification of RRM2 Suppresses Tumor-Associated M2 Macrophage Polarization and Colorectal Cancer Growth

Tianlin Feng, Xiaoya Zhou, Li Li, Wenyi Zheng et autres

cn (code pays fourni par la source)

Screening scaffold proteins for improved functional delivery of luminal proteins using engineered extracellular vesicles

Zheyu Niu, Houze Zhou, Wenyi Zheng, Oliver G. Hayes et autres

The potential for engineered extracellular vesicles (EVs) to efficiently deliver biotherapeutics is still largely untapped. One of the key structures in determining cargo loading and subsequent functional delivery efficiency of engineered EVs is the sorting protein (scaffold). To determine the role of …

cn, se (code pays fourni par la source)

Mechanisms underlying seizures and hypothermia during busulphan administration

Ibrahim El Serafi, Sofia Berglund, Fadwa Benkessou, Alina Codita et autres

Abstract Busulphan (Bu) is used as a part of the conditioning regimen prior to HSCT. Neurotoxicity is one of Bu major adverse-effects. We investigated the kinetics of busulphan and its metabolites (tetrahydothiophene, tetrahydrothiophene-1-oxide, sulfolane, 3-OH-sulfolane) in patients and mice as well as …

ae, se, cn, ir, ca (code pays fourni par la source)

Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors

Xiuming Liang, Dhanu Gupta, Junhua Xie, Elien Van Wonterghem et autres

Intracellular delivery of protein and RNA therapeutics represents a major challenge. Here, we develop highly potent engineered extracellular vesicles (EVs) by incorporating bio-inspired attributes required for effective delivery. These comprise an engineered mini-intein protein with self-cleavage activity for active cargo loading and …

se, cn, gb, be, co, de, nl, ee (code pays fourni par la source)

The Role of N-acetylcysteine Amide in Acute Graft-versus-host Disease Mouse Model

Rui He, Wenyi Zheng, Kicky Rozing, Carlos Fernández Moro et autres

Abstract Graft-versus-host disease (GvHD) remains one of the major complications following allogeneic hematopoietic cell transplantation (allo-HCT), resulting in reduced quality of life, morbidity, and mortality in transplanted patients. Clinical strategies to prevent GvHD are frequently associated with off-target effects and dose-related toxicity. …

se, nl, cn (code pays fourni par la source)