Tanweer Rashid

Intensive versus standard blood pressure control and overall brain small vessel disease burden: a post-hoc analysis of the SPRINT randomized clinical trial

Sokratis Charisis, Nicholas M. Pajewski, Larry R. Price, Ngoc Huynh Ho et autres

Background: The benefits of improved systolic blood pressure (SBP) control on stroke, coronary heart disease, and heart failure are well-established, yet its effect on overall cerebral small vessel disease (SVD) burden remains uncharacterized. We examined the association between intensive SBP control and …

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Association of Lacunes with Risk Factors, Cognition, and Atrophy: The Multi-Ethnic Study of Atherosclerosis (MESA)

David H. Wang, Faiza Azhar, Niyas Shamsudeen, Jose Gutierrez et autres

Background: Lacunes are 3-15 mm cavities originating from small perforating artery disease and are a hallmark of cerebral small vessel disease (cSVD). Prior prevalence studies relied on manual rating, which is prone to inter-rater variability and cannot quantify volume. We applied deep …

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Comparative Analysis of Artificial Intelligence–Based Quantification versus Visual Rating of Enlarged Perivascular Spaces in the Multi-Ethnic Study of Atherosclerosis Cohort

Sokratis Charisis, Tanweer Rashid, Sachintha Ransara Brandigampala, Kevin D. Hiatt et autres

BACKGROUND AND PURPOSE: Enlarged perivascular spaces (PVS) are fluid-filled spaces surrounding small cerebral vessels. Current PVS research has been limited by the absence of efficient and scalable quantification tools. We compared visual ratings versus artificial intelligence (AI)-based quantification in identifying associations of …

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Bridging Neuroimaging and Pathology in Dementia: A Multi‐Cohort Investigation of MRI‐Derived Brain Volumes

Rajeswar Kumar, Tanweer Rashid, Sokratis Charisis, Karl Li et autres

BACKGROUND: The ability to precisely characterize neurodegenerative diseases at early stages remains a challenge. Understanding the relationship between magnetic resonance Imaging (MRI)-derived brain volumes and neuropathological outcomes is key to advancing early and accurate diagnosis of neurodegenerative diseases. While MRI-based volumetrics are …

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Assessing the Global Impact of Brain Small Vessel Disease on Cognition: The Multi‐Ethnic Study of Atherosclerosis

Sokratis Charisis, Tanweer Rashid, Christina S. Dintica, Mitzi M. Gonzales et autres

INTRODUCTION: We aimed to examine the global impact of brain small vessel disease (SVD) on cognitive performance. METHODS: In 892 participants from the Multi-Ethnic Study of Atherosclerosis (MESA), we derived perivascular spaces (PVS), white matter hyperintensities (WMH), microbleeds (MB), and white matter …

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Convolutional Neural Networks for the segmentation of hippocampal structures in postmortem MRI scans

Karl Li, Nicolas Honnorat, Tanweer Rashid, Di Wang et autres

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Multi-atlas multi-modality morphometry analysis of the South Texas Alzheimer’s Disease Research Center postmortem repository

Nicolas Honnorat, Mariam Mojtabai, Karl Li, Jinqi Li et autres

Histopathology provides critical insights into the neurological processes inducing neurodegenerative diseases and their impact on the brain, but brain banks combining histology and neuroimaging data are difficult to create. As part of an ongoing global effort to establish new brain banks providing …

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Association of quantitative susceptibility mapping signal in gray matter with clinical characteristics and aging-related MRI markers: The Multi-Ethnic Study of Atherosclerosis

Susan R. Heckbert, Paul N. Jensen, Tanweer Rashid, David H. Wang et autres

BACKGROUND AND OBJECTIVES: In neuropathologic studies, iron accumulation in gray matter (GM) is associated with aging and specific neurological diseases, but less is known about its correlates in community-based populations. METHODS: In the Multi-Ethnic Study of Atherosclerosis, brain MRI was conducted in …

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Urinary Metal Levels, Cognitive Test Performance, and Dementia in the Multi-Ethnic Study of Atherosclerosis

Arce Domingo-Relloso, Katlyn E. McGraw, Susan R. Heckbert, Jose Alejandro Luchsinger et autres

Importance: Metals are established neurotoxicants, but evidence of their association with cognitive performance at low chronic exposure levels is limited. Objective: To investigate the association of urinary metal levels, individually and as a mixture, with cognitive tests and dementia diagnosis, including effect …

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Spatial heterogeneity in white matter hyperintensities revealed by postmortem MRI‐guided histopathological staining

Mariam Mojtabai, Karl Li, Tanweer Rashid, Jinqi Li et autres

Abstract Background White matter (WM) hyperintensities are bright areas on T2 MRI that reflect increased interstitial fluid caused by demyelination and axonal loss; these tissue alterations have been associated with cognitive impairment. Previous in‐vivo studies have suggested that the underlying pathogenesis for …

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Modelling Small Vessel Disease Using Regional MRI Markers, and Mediating Effects on Cognitive Decline

Sokratis Charisis, Tanweer Rashid, Christina S. Dintica, Mitzi M. Gonzales et autres

Abstract Background The location of proposed brain MRI markers of small vessel disease (SVD) might reflect their pathogenesis and may translate into differential associations with cognition. We derived regional MRI markers of SVD and studied: (i) associations with cognitive performance, (ii) patterns …

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Plasma Proteomic Determinants of Small Vessel Disease of the Brain: the Multi‐Ethnic Study of Atherosclerosis

Rizwan Kalani, Alison E. Fohner, Thomas R. Austin, Sheina Emrani et autres

Abstract Background The identification of novel blood‐based biomarkers of small vessel disease of the brain (SVD) may improve pathophysiologic understanding and inform the development of new therapeutic strategies for prevention. We evaluated plasma proteomic associations of white matter fractional anisotropy (WMFA), white …

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