Association of quantitative susceptibility mapping signal in gray matter with clinical characteristics and aging-related MRI markers: The Multi-Ethnic Study of Atherosclerosis
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Le résumé fourni par la source
BACKGROUND AND OBJECTIVES: In neuropathologic studies, iron accumulation in gray matter (GM) is associated with aging and specific neurological diseases, but less is known about its correlates in community-based populations. METHODS: In the Multi-Ethnic Study of Atherosclerosis, brain MRI was conducted in 2018-2019. To estimate iron content, we derived the median quantitative susceptibility mapping (QSM) signal from four regions: the basal ganglia and cortical GM of the frontal, temporal, and parietal lobes. We examined cross-sectional associations with demographic and clinical characteristics, cognitive test performance, gait speed, and brain MRI measures of atrophy and small vessel disease. RESULTS: We studied 943 participants (14 % Chinese, 25 % Black, 20 % Hispanic, 41 % White; mean age 74 years; 48 % men). In multivariable models, higher left basal ganglia QSM signal was associated with older age (7.2 ppb per 10 years; 95 %CI 4.6,9.9), smoking (7.1; 3.4,10.9), and diabetes (7.4; 2.5,12.3). Lower QSM signal was associated with Black race (-15.3; -20.6,-10, relative to White) and higher high-density lipoprotein cholesterol (-3.4 per 20 mg/dL; -5.8,-0.9). In cortical GM, QSM signal was associated with greater waist circumference, lifetime alcohol use, and log-transformed white matter hyperintensity (WMH) volume (0.08-0.12 SD units per SD, all p ≤ 0.002), but not with cognitive test performance or gait speed. DISCUSSION: In cross-sectional analyses in a community-based cohort, older age, White race, smoking, diabetes, and greater WMH volume were associated with higher QSM signal in basal ganglia and/or cortical GM. Longitudinal studies are needed to further explore GM QSM signal in relation to cognition and gait in older individuals.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Association of quantitative susceptibility mapping signal in gray matter with clinical characteristics and aging-related MRI markers: The Multi-Ethnic Study of Atherosclerosis
- Date Crossref
- 01/01/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Washington Cardiovascular Health Research Unit pays non établi dans la noticeUniversité ou école supérieure
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University of Washington Applied Physics Laboratory pays non établi dans la noticeStructure de recherche
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The University of Texas at San Antonio Health Science Center pays non établi dans la noticeUniversité ou école supérieure
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Institute for Neurodegenerative Disorders pays non établi dans la noticeOrganisation à but non lucratif
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Department of Health pays non établi dans la noticeOrganisme public
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Wake Forest University pays non établi dans la noticeUniversité ou école supérieure
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University of Pennsylvania pays non établi dans la noticeUniversité ou école supérieure
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University of Texas Health Science Center San Antonio Neuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core pays non établi dans la noticeUniversité ou école supérieure
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Columbia University Mailman School of Public Health Departments of Biostatistics and Environmental Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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Wake Forest School of Medicine Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
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Perelman School of Medicine Department of Radiology pays non établi dans la noticeUniversité ou école supérieure
Cardiovascular Health Research Unit — University of Washington, University of Washington Applied Physics Laboratory et The University of Texas at San Antonio Health Science Center, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.