Bridging Neuroimaging and Pathology in Dementia: A Multi‐Cohort Investigation of MRI‐Derived Brain Volumes
Rattachement africain : us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: The ability to precisely characterize neurodegenerative diseases at early stages remains a challenge. Understanding the relationship between magnetic resonance Imaging (MRI)-derived brain volumes and neuropathological outcomes is key to advancing early and accurate diagnosis of neurodegenerative diseases. While MRI-based volumetrics are widely used to assess structural changes in vivo, their link to neuropathological findings remains underexplored. This study examines associations between region-specific brain atrophy and neuropathological markers, including Alzheimer's Disease Neuropathologic Change (ADNC), CERAD score, Braak staging, and Thal amyloid phase, leveraging volumetric data across multiple aging cohorts. METHOD: T1-weighted MRI scans from participants in longitudinal dementia cohorts (ROS, MAP, MARS, and NACC) were pre-processed, and brain volumes of 120 cerebral regions of interest (ROIs) were calculated using Multi-Atlas Segmentation Utilizing Ensembles (MUSE). Associations between ROI volumes and neuropathological metrics were analysed using linear regression, adjusting for age at scan, difference between age at death and age at scan, sex, intracranial volume, and site/scanner. Neuropathological metrics, including ADNC, CERAD scores, Thal phase, Braak staging, and vascular metrics like atherosclerosis were analysed as continuous variables grouped categorically (e.g., Thal phase recoded into three categories: 0, 1, and 2). Statistical significance was determined using Benjamini-Hochberg method (p <0.05). RESULT: Among 755 participants (mean age at scan: 80.57±10.23 years; mean age at death: 85.49±10.45 years; 44% male), ADNC was associated with atrophy in temporal and parietal regions, notably middle and inferior temporal gyri, angular gyrus, and amygdala. CERAD scores correlated with atrophy in middle temporal, para-hippocampal, and fusiform gyrus, Thal phase with atrophy in middle temporal, angular gyrus, and precuneus and Braak staging showed atrophy in entorhinal cortex, middle temporal gyrus, and para-hippocampal regions. Atherosclerosis was associated with atrophy in prefrontal cortex, and parieto-occipital regions. CONCLUSION: These findings highlight the potential of MRI-derived volumetrics as non-invasive biomarkers of underlying Alzheimer's pathology. Our findings demonstrate notable atrophy in medial temporal, lateral temporoparietal, and midline parietal regions, supporting recognized AD patterns of neurodegeneration, consistent with pivotal studies by Habes et al.,(2016), Dickerson et al.,(2009). Associations between amyloid, tau burdens and atrophy in temporal, parietal, and limbic regions underscore their diagnostic value in neurodegeneration.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Bridging Neuroimaging and Pathology in Dementia: A Multi‐Cohort Investigation of MRI‐Derived Brain Volumes
- Date Crossref
- 01/12/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
The University of Texas at San Antonio Health Science Center pays non établi dans la noticeUniversité ou école supérieure
-
Institute for Neurodegenerative Disorders pays non établi dans la noticeOrganisation à but non lucratif
-
University of Southern California pays non établi dans la noticeUniversité ou école supérieure
-
University of Washington National Alzheimer's Coordinating Center pays non établi dans la noticeUniversité ou école supérieure
-
National Alzheimer's Coordinating Center pays non établi dans la noticeInstitution
-
Indiana University School of Medicine Department of Radiology and Imaging Sciences pays non établi dans la noticeUniversité ou école supérieure
-
Indiana University – Purdue University Indianapolis pays non établi dans la noticeUniversité ou école supérieure
-
The University of Texas Health Science Center at Houston Glenn Biggs Institute for Alzheimer's & pays non établi dans la noticeUniversité ou école supérieure
-
Vanderbilt University Medical Center Department of Neurology pays non établi dans la noticeÉtablissement de santé
-
University of California Department of Radiology and Biomedical Imaging pays non établi dans la noticeUniversité ou école supérieure
-
Rush University Medical Center Rush Alzheimer's Disease Center pays non établi dans la noticeÉtablissement de santé
-
Vanderbilt University Vanderbilt Memory and Alzheimer's Center pays non établi dans la noticeUniversité ou école supérieure
The University of Texas at San Antonio Health Science Center, Institute for Neurodegenerative Disorders et University of Southern California, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.