Assessing the Global Impact of Brain Small Vessel Disease on Cognition: The Multi‐Ethnic Study of Atherosclerosis
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Le résumé fourni par la source
INTRODUCTION: We aimed to examine the global impact of brain small vessel disease (SVD) on cognitive performance. METHODS: In 892 participants from the Multi-Ethnic Study of Atherosclerosis (MESA), we derived perivascular spaces (PVS), white matter hyperintensities (WMH), microbleeds (MB), and white matter fractional anisotropy (FA) and trace (TR). Cognitive function was assessed with a comprehensive neuropsychological battery. RESULTS: A composite SVD measure was constructed as a linear combination of basal ganglia PVS, thalamus PVS, periventricular WMH, subcortical WMH, and white matter FA and TR, and exhibited associations with worse global and domain-specific cognitive performance. Additionally, SVD mediated the effect of age and cardiovascular disease risk on global cognitive function, both directly and through smaller gray matter (GM) volume. DISCUSSION: Integrating multiple individual SVD endophenotypes may more accurately reflect the neurobiology of SVD and capture its global impact on cognition. SVD mediates the effects of age and cardiovascular disease risk on cognition through both atrophy-related and non-atrophy-related pathways. HIGHLIGHTS: Associations between individual magnetic resonance imaging (MRI) markers of brain small vessel disease and cognitive outcomes might not fully capture the global impact of small vessel disease on cognition. We modeled small vessel disease as a latent construct, integrating multiple MRI endophenotypes in strategic brain regions. The small vessel disease construct was associated with worse global and domain-specific cognitive performance. The small vessel disease construct exhibited mediating effects in the relationships of aging and cardiovascular disease risk with cognition through pathways that both involve and are independent of brain atrophy. Integrating information from multiple relevant imaging endophenotypes could open new avenues in small vessel disease research, broadening our understanding of its risk factors and clinical correlates.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Assessing the Global Impact of Brain Small Vessel Disease on Cognition: The Multi‐Ethnic Study of Atherosclerosis
- Date Crossref
- 01/06/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
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Department of Neurology University of Texas Health Science Center at San Antonio San Antonio Texas USA pays non établi dans la noticeUniversité ou école supérieure
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Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases University of Texas Health Science Center San Antonio San Antonio Texas USA pays non établi dans la noticeUniversité ou école supérieure
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Department of Internal Medicine Wake Forest School of Medicine Winston‐Salem North Carolina USA pays non établi dans la noticeUniversité ou école supérieure
The University of Texas at San Antonio Health Science Center, University of California et Cedars-Sinai Medical Center, avec 9 autres affiliations.
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