Pedro María Martínez Pérez-Crespo

Symptoms of focal hypertonia with progression to generalised involvement

Noelia Guerrero Carmona, Pedro María Martínez Pérez-Crespo, María del Carmen Fernández Moreno

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Mortality risk of ESBL producers in Escherichia coli bacteraemia: a comprehensive analysis using the PROBAC cohort

Paula Olivares-Navarro, Pérez Rodríguez, Adrian Sousa, Josune Goikoetxea et autres

OBJECTIVE: The incidence of bloodstream infection (BSIs) due to extended-spectrum β-lactamase (ESBL) producing Escherichia coli is increasing worldwide. There is controversy as to whether ESBL production in itself is associated with higher mortality. The aim of this study is to evaluate the …

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A matched case-control study on Escherichia coli factors contributing to sepsis and septic shock in bacteraemic patients

Natalia Andrea Maldonado, Inmaculada López-Hernández, John Karlsson Valik, Luis Eduardo López-Cortes et autres

One third of patients with Escherichia coli bacteraemia develop a dysregulated inflammatory response (sepsis/septic shock). Our objective was to investigate whether specific microbiological determinants of E. coli are associated to presentation with sepsis/shock. A matched case-control study was performed; 101 case-patients with …

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Role of Giannella and Increment Scores to Predict OXA-48 Carbapenemase Producing Enterobacterales Infection and Mortality in Previous Rectal Carriers

Pedro María Martínez Pérez-Crespo, José Luis Cuevas-Corrales, Eva Torres, Miguel Rodríguez-Fernández et autres

Abstract Aim To assess the ability of Giannella Risk Score (GRS), Increment Score (IS), and modified-Increment Score (m-IS) to predict the risk of infection after colonization by OXA-48 producing Enterobacterales (OXA-48-Ent) and mortality after infection. Methods A retrospective cohort study (2020–2022) including …

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External validation of the predictive ability of Charson, SOFA, Pitt, INCREMENT-ESBL and bloodstream infection mortality Risk for 30-day-mortality in bacteraemia using the PROBAC cohort data

Sandra De la Rosa-Riestra, Belén Gutiérrez‐Gutiérrez, Inmaculada López-Hernández, María Teresa Pérez-Rodríguez et autres

INTRODUCTION: The development of predictive mortality scores for bacteraemia is fundamental for identifying patients in whom increasing our management efforts. However, it is necessary to assess the validity of the results obtained when they are applied to new cohorts. METHODS: We evaluated …

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West Nile Virus Infection in Seville. An Emergent Infection in Spain

Ana Caro Leiro, Pedro María Martínez Pérez-Crespo, Manuela Aguilar Guisado, Cristina Roca-Oporto et autres

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Mortality predictors and definition proposal for complicated coagulase-negative Staphylococcus bacteraemia: a multicentre prospective cohort study

Benedetta Varisco, Pedro María Martínez Pérez-Crespo, Pilar Retamar, Inmaculada Hernandez et autres

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Real-world effectiveness of early anti-SARS therapy in severely immunocompromised COVID-19 outpatients during the SARS-CoV-2 omicron variant era: a propensity score–adjusted retrospective cohort study

Héctor Pinargote‐Celorio, Óscar Moreno, Pilar González-de-la-Aleja, Jara Llenas‐García et autres

BACKGROUND: The effectiveness of the early treatment for antiviral agents in SARS-CoV-2 infection is closely related to patient comorbidities. Data on effectiveness in immunocompromised patients are limited, with reports involving highly heterogeneous and not well-defined populations. We aimed to assess the effectiveness …

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Early antibiotic de-escalation in patients with severe infections due to bloodstream infection by enterobacterales: A post hoc analysis of a prospective multicentre cohort

Francesc Escrihuela-Vidal, Zaira Raquel Palacios-Baena, Pérez Rodríguez, José María Reguera Iglesias et autres

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Clinical characteristics, predisposing factors and outcomes for Enterococcus faecalis versus Enterococcus faecium bloodstream infections: a prospective multicentre cohort study

Fenna Scharloo, Francesco Cogliati Dezza, Inmaculada López-Hernández, Pedro María Martínez Pérez-Crespo et autres

PURPOSES: Enterococcal BSI is associated with significant morbidity and mortality, with fatality rates of approximately 20-30%. There are microbiological and clinical differences between E. faecalis and E. faecium infections. The aim of this study was to investigate differences in predisposing factors for …

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A comprehensive, predictive mortality score for patients with bloodstream infections (PROBAC): a prospective, multicentre cohort study

Sandra De la Rosa-Riestra, Inmaculada López-Hernández, María Teresa Pérez-Rodríguez, Adrián Sousa et autres

OBJECTIVES: Bloodstream infections (BSI) are an important cause of mortality, although they show heterogeneity depending on patients and aetiological factors. Comprehensive and specific mortality scores for BSI are scarce. The objective of this study was to develop a mortality predictive score in …

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Differences in clinical outcomes of bloodstream infections caused by Klebsiella aerogenes, Klebsiella pneumoniae and Enterobacter cloacae: a multicentre cohort study

Mariana Nunes Pinho Guedes, David Gathara, Inmaculada López-Hernández, Pedro María Martínez Pérez-Crespo et autres

BACKGROUND: Klebsiella aerogenes has been reclassified from Enterobacter to Klebsiella genus due to its phenotypic and genotypic similarities with Klebsiella pneumoniae. It is unclear if clinical outcomes are also more similar. This study aims to assess clinical outcomes of bloodstreams infections (BSI) …

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