Christian Herr

Extracellular vesicle surface markers inform on COPD severity and mortality in COSYCONET

Roman Martin, Katrin Laakmann, Hendrik Pott, Wilhelm Bertrams et autres

Abstract Background Chronic obstructive pulmonary disease (COPD) is a leading cause of global morbidity and mortality, and its heterogeneity demands better biomarkers of severity and progression risk. Extracellular vesicles (EVs) are promising blood-based biomarkers, but have not been examined for COPD severity …

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Modeling of lung-liver interaction during infection in a human fluidic organ-on-a-chip

Susanne Reinhold, Christian Herr, Yiwen Yao, Mehdi Pourrostami et autres

Respiratory infections, including pneumonia and COVID-19, are major causes of global mortality and morbidity. Recent advancements in organ-on-a-chip (OOC) technologies have paved the way for human-based disease models, offering new tools for studying disease mechanisms and accelerating drug development. The aim of …

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Alveolar Macrophage based personalized therapy for the delivery of IL-37 in inflammatory airway disease like COPD

Isabell Theisohn, Christoph Beißwenger, Christian Herr, Robert Bals

Alveolar Macrophages (AM) are self-renewing, tissue resident immune cells in the lung. Interleukin 37 (IL-37) has anti-inflammatory properties to prevent hyper-inflammation and tissue damage. It has been shown to counteract cigarette smoke induced inflammation by inhibiting expression and secretion of pro-inflammatory cytokines. …

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Statins did not reduce exacerbation rate in COPD with cardiovascular comorbidities (data from COSYCONET)

Sebastian Fähndrich, N. Frantzi, RA Jörres, Peter J. Alter et autres

Background : The effects of statins on exacerbation risk in COPD remains unclear. Previous studies often excluded patients with cardiovascular comorbidities despite their high prevalence in COPD and role for exacerbations. Based on the cardioprotective properties of statins, we hypothesised that statins …

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Midregional proatrial naturetic peptide (MRproANP) and copeptin (COPAVP) as predictors of all cause mortality in recently diagnosed mild to moderate COPD – Results from COSYCONET

Sebastian Fähndrich, Peter J. Alter, Christian Herr, Benjamin Waschki et autres

Background : MRproANP and COPAVP are prognostic markers for mortality in chronic obstructive pulmonary disease (COPD). Furthermore, these biomarkers predict mortality due to cardiovascular diseases, which are important prognostically determining comorbidities in patients with COPD. However, less is known about these biomarkers …

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Tracheal tuft cells release ATP and link innate to adaptive immunity in pneumonia

Noran Abdel Wadood, Monika I. Hollenhorst, Mohamed Ibrahem Elhawy, Na Zhao et autres

Tracheal tuft cells shape immune responses in the airways. While some of these effects have been attributed to differential release of either acetylcholine, leukotriene C4 and/or interleukin-25 depending on the activating stimuli, tuft cell-dependent mechanisms underlying the recruitment and activation of immune …

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Systematic assessment of COVID-19 host genetics using whole genome sequencing data

Axel Schmidt, Nicolas Casadei, Fabian Brand, German Demidov et autres

Courses of SARS-CoV-2 infections are highly variable, ranging from asymptomatic to lethal COVID-19. Though research has shown that host genetic factors contribute to this variability, cohort-based joint analyses of variants from the entire allelic spectrum in individuals with confirmed SARS-CoV-2 infections are …

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Co-culture of human AT2 cells with fibroblasts reveals a MUC5B phenotype: insights from an organoid model

Yiwen Yao, Felix Ritzmann, Sarah Miethe, Kathrin Kattler‐Lackes et autres

Impaired interaction of fibroblasts with pneumocytes contributes to the progression of chronic lung disease such as idiopathic pulmonary fibrosis (IPF). Mucin 5B (MUC5B) is associated with IPF. Here we analyzed the interaction of primary fibroblasts and alveolar type 2 (AT2) pneumocytes in …

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Decoding the diagnostic and therapeutic potential of microbiota using pan-body pan-disease microbiomics

Georges Pierre Schmartz, Jacqueline Rehner, Madline Priska Gund, Verena Keller et autres

The human microbiome emerges as a promising reservoir for diagnostic markers and therapeutics. Since host-associated microbiomes at various body sites differ and diseases do not occur in isolation, a comprehensive analysis strategy highlighting the full potential of microbiomes should include diverse specimen …

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Alveolar Macrophage based personalized therapy for the delivery of IL-37

Isabell Theisohn, Christoph Beißwenger, Christian Herr, Robert Bals

Alveolar Macrophages (AM) are self-renewing, tissue resident immune cells in the lung. Interleukin 37 has anti-inflammatory properties to prevent hyper-inflammation and tissue damage. IL-37 has been shown to counteract asthma or cigarette smoke induced inflammation. The cytokine downregulates allergic airway inflammation by …

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Midregional pro atrial naturetic peptide (MRproANP) is a predictor of all-cause mortality in mild to moderate COPD - an analysis of COSYCONET data

Sebastian Fähndrich, Christian Herr, Sebastian Teuteberg, Peter J. Alter et autres

Background: When chronic obstructive pulmonary disease (COPD) is newly diagnosed in the mild to moderate stages (Global Initiative for chronic obstructive Lung Disease [GOLD] stage 0-2), it is difficult to identify patients at increased risk of death. Methods: Therefore, we examined the …

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Corrigendum: TAp73 is a central transcriptional regulator of airway multiciliogenesis

Alice Nemajerová, Daniela Kramer, Saul S. Siller, Christian Herr et autres