Na Zhao

Immediate Postoperative Serum Albumin as an Adjunctive Triage Aid for Early Acute Kidney Injury in Neonates After Non-Cardiac Surgery: A Retrospective Cohort Study

Liming Cheng, Haifei Gu, Chunyan Chen, Yihong Li et autres

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Research on biliary atresia and epigenetic factors from the perspective of transcriptomics: identification of key genes and experimental validation

Na Zhao, Hang Yang, Li Chen, Bo Hai et autres

Background: Biliary atresia (BA) is a severe pediatric liver disease. However, the role of epigenetic factors in its pathogenesis remains poorly understood. This study aimed to identify key genes associated with BA and epigenetic factors, as well as to explore potential therapeutic …

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Association between Life's Essential 8 and frailty among the United States older people

Na Zhao, Yameng Fan

Background The association between cardiovascular disease health (CVH) and frailty has not been conclusive. The American Heart Association (AHA) has proposed the Life's Essential 8 (LE8) score as an indicator of CVH. We sought to examine the association between LE8 and frailty …

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Oligodendrocyte precursor cells facilitate neuronal lysosome release

Li‐Pao Fang, Ching-Hsin Lin, Yasser Medlej, Renping Zhao et autres

Oligodendrocyte precursor cells (OPCs) shape brain function through many non-canonical regulatory mechanisms beyond myelination. Here we show that OPCs form contacts with their processes on neuronal somata in a neuronal activity-dependent manner. These contacts facilitate exocytosis of neuronal lysosomes. A reduction in …

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Morphology and Distribution of Fat Globules in Osteomyelitis on Magnetic Resonance Imaging

Liyuan Xie, Lei Cao, Wenjuan Wu, Ji-cun Liu et autres

INTRODUCTION: The purpose of this study was to investigate the morphology and distribution characteristics of fat globules in osteomyelitis on magnetic resonance imaging (MRI). MATERIALS AND METHODS: Patients with pathologically-confirmed osteomyelitis and MRI scans were retrospectively enrolled, and fat globules on the …

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Tracheal tuft cells release ATP and link innate to adaptive immunity in pneumonia

Noran Abdel Wadood, Monika I. Hollenhorst, Mohamed Ibrahem Elhawy, Na Zhao et autres

Tracheal tuft cells shape immune responses in the airways. While some of these effects have been attributed to differential release of either acetylcholine, leukotriene C4 and/or interleukin-25 depending on the activating stimuli, tuft cell-dependent mechanisms underlying the recruitment and activation of immune …

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Landscape of Metabolic Reprogramming in Crystalline Silica-Induced Fibroblasts Reveals the Potential Therapeutic Target Glutamate Metabolism Pathway

Yiru Qin, Jiayin Feng, Lin Zhong, Jianling Shen et autres

Author Correction: Adenosine triggers early astrocyte reactivity that provokes microglial responses and drives the pathogenesis of sepsis-associated encephalopathy in mice

Qilin Guo, Davide Gobbo, Na Zhao, Hong Zhang et autres

The original version of this Article contained incorrect graphs in Figure 6h. In the original Figure 6h, the colour coding of the curves in the middle panel (6hpi) and right panel (24hpi) were inadvertently reversed. Specifically, the black curves in these panels …

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Adenosine triggers early astrocyte reactivity that provokes microglial responses and drives the pathogenesis of sepsis-associated encephalopathy in mice

Qilin Guo, Davide Gobbo, Na Zhao, Hong Zhang et autres

Molecular pathways mediating systemic inflammation entering the brain parenchyma to induce sepsis-associated encephalopathy (SAE) remain elusive. Here, we report that in mice during the first 6 hours of peripheral lipopolysaccharide (LPS)-evoked systemic inflammation (6 hpi), the plasma level of adenosine quickly increased …

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Predicting “pain genes”: multi-modal data integration using probabilistic classifiers and interaction networks

Na Zhao, David Bennett, Georgios Baskozos, Allison M Barry

Abstract Accurate identification of pain-related genes remains challenging due to the complex nature of pain pathophysiology and the subjective nature of pain reporting in humans, or inferring pain states in animals on the basis of behaviour. Here, we use a machine learning …

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Neuronal lysosome transfer to oligodendrocyte precursor cells: a novel mechanism of neuron-glia communication and its role in neurodegenerative diseases

Li‐Pao Fang, Ching-Hsin Lin, Yasser Medlej, Renping Zhao et autres

Abstract Oligodendrocyte precursor cells (OPCs) shape brain function through intricate regulatory mechanisms. Here, we observed that OPC processes establish connections with neuronal somata, with smaller lysosomes positioned near these contact sites. Tracking lysosomes demonstrated neuronal lysosomes were attracted to and released at …

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Predicting ‘pain genes’: multi-modal data integration using probabilistic classifiers and interaction networks

Na Zhao, David Bennett, Georgios Baskozos, Allison M Barry

Motivation: Accurate identification of pain-related genes remains challenging due to the complex nature of pain pathophysiology and the subjective nature of pain reporting in humans. Here, we use machine learning to identify possible 'pain genes'. Labelling was based on a gold-standard list …

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