Ke Shi

Development of cell-active BRD4-D1 selective inhibitors to decode the role of BET proteins in LPS-mediated liver inflammation

Cole R. Scholtz, Luke C. Doskey, Sai Giridhar Sarma Kandanur, Nora R. Vail et autres

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Who Listens, How We Share: Social Context Effects on Mood in Brief Reminiscence Among Older Adults in China

Ke Shi

Abstract Older adults face heightened risks of depression and affective dysregulation, particularly in low-resource contexts. Reminiscence, involving the structured recall of autobiographical memories, has been shown to improve emotional well-being, but most evidence comes from multi-session interventions in Western populations. The immediate …

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The structural basis for the selective antagonism of soluble TNF-alpha by shark variable new antigen receptors

Obinna C. Ubah, Eric W. Lake, Kendahl L. Ott, Stella Priyanka et autres

The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α) is synthesized as transmembrane TNF-α (tmTNF-α) where proteolytic processing releases soluble TNF-α (sTNF-α). tmTNF-α can act as either a ligand by activating TNF receptors, or a receptor that transmits reverse (outside-to-inside) signalling after binding to …

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Structural basis for sequence context-independent single-stranded DNA cytosine deamination by the bacterial toxin SsdA

Lulu Yin, Yanjun Chen, Ke Shi, Emilia Barreto-Durán et autres

DNA deaminase toxins are involved in interbacterial antagonism and the generation of genetic diversity in surviving bacterial populations. These enzymes have also been adopted as genome engineering tools. The single-stranded (ss)DNA deaminase SsdA is representative of the bacterial deaminase toxin family-2 (BaDTF2), …

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Directed Evolution of Xylanase from Dickeya dadantii DCE-01 with Improved Enzymatic Activity

Ruijun Wang, Ke Shi, Ke Zheng, Qi Yang et autres

Xylanase, an essential enzyme for breaking down xylan, faces limitations in its industrial applications due to the relatively low catalytic activity of the wild type. Directed evolution was used to enhance the catalytic efficiency of xylanase that originated from the Dickeya dadantii …

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Developing a universal electrochemical biosensor via rolling circle amplification and electrochemical rectification

Yuting Zhang, Zongkang Guo, Xiaoyi Wang, Ke Shi et autres

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[Exploring the advantages of traditional Chinese medicine and dual-anti therapy for liver cirrhosis].

Y Q Li, X B Wang, Ke Shi, Yali Liu

Liver cirrhosis is the terminal stage of chronic liver disease. Minimizing complications of liver cirrhosis and the occurrence of liver cancer has become an important goal for liver cirrhosis treatment. The primary etiology leading to liver cirrhosis is chronic hepatitis B infection. …

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Multiple Loci DNA Methylation Profiling for Rapid Colorectal Cancer Diagnosis Based on a Smartphone-Integrated Microfluidic Biosensing Platform

Shixin Cai, Ke Shi, A.Y. Ji, Yilin Long et autres

Methylation level of circulating tumor DNA (ctDNA) is widely recognized as a pivotal biomarker in precision oncology for tumor characterization and risk assessment. However, current point-of-care testing platforms for methylation analysis are constrained in achieving sufficient detection specificity due to their limitations …

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Crystal structures of 40- and 71-substitution variants of hydroxynitrile lyase from rubber tree

Colin T. Pierce, Panhavuth Tan, Lauren R. Greenberg, Meghan E. Walsh et autres

Hydroxynitrile lyase from Hevea brasiliensis ( Hb HNL) and the esterase SABP2 from Nicotiana tabacum share the α/β-hydrolase fold, a Ser–His–Asp catalytic triad and 44% sequence identity, yet catalyze different reactions. Prior studies showed that three active-site substitutions in Hb HNL conferred …

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Crystal structure of a seven-substitution mutant of hydroxynitrile lyase from rubber tree

Colin T. Pierce, Lauren R. Greenberg, Meghan E. Walsh, Ke Shi et autres

The α/β-hydrolase fold superfamily includes esterases and hydroxynitrile lyases which, despite catalyzing different reactions, share a Ser–His–Asp catalytic triad. We report a 1.99 Å resolution crystal structure of HNL6V, an engineered variant of hydroxynitrile lyase from Hevea brasiliensis ( Hb HNL) containing …

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Crystal structure of the folded domains of Xrs2 from Saccharomyces cerevisiae

Ajeak Vigneswaran, Ke Shi, Hideki Aihara, Robert L. Evans et autres

The MRE11-RAD50-NBS1/Xrs2 (MRN/X) protein complex acts as a first responder in DNA double-strand break repair and telomere-length maintenance, yet the structural architecture of the yeast ortholog Xrs2 has remained unresolved. In this study, we present the first structure of the folded N-terminal …

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Bibliometric and visualization analysis of cancer associated with intestinal flora through genetics and epigenetics from 1991 to 2024

Li Yang, Ke Shi, Hong Qi, Qian Cai et autres

BACKGROUND: Intestinal flora, or gut microbiota, has increasingly been recognized for its potential role in cancer development and progression. Beyond direct interactions with systemic organs, gut microbiota and its metabolites can modulate epigenetic processes such as DNA methylation, histone modification, and non-coding …

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