Omar Moukha‐Chafiq

Synthesis of novel 6-azacytidine prodrugs as potent influenza A inhibitors

Omar Moukha‐Chafiq, Larry Bratton, Shuklendu D. Karyakarte, Kathy A. Keith et autres

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239 Discovery of non-aminoglycoside small molecules that enhance eRF3 degrader-induced translational readthrough of CFTR nonsense mutations

S. Rowe, Jianguo Chen, Joanne Kivela Tillotson, Yuping Li et autres

312 Small molecules as aminoglycoside enhancers to promote readthrough for the treatment of cystic fibrosis

Corinne E. Augelli‐Szafran, J. Tillotson, Omar Moukha‐Chafiq, Vibha Pathak et autres

Targeting west nile virus replication by xanthine inhibitors

Theresa Nguyen, Jessica R. Smith, Shuklendu D. Karyakarte, Fuad Al Abir et autres

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Development of Delta Opioid Receptor Antagonists Which Prevent Alzheimer’s Disease-Like Pathology in the 5X-Familial Alzheimer’s Disease [5XFAD] Mouse Model

Parthasaradhireddy Tanguturi, Stefanie Mitchell, Omar Moukha‐Chafiq, Sixue Zhang et autres

Alzheimer’s Disease is a growing health concern, with no available disease-modifying treatments. A previous report suggested that a Delta Opioid Receptor (DOR) antagonist could prevent Alzheimer’s-like pathology; however, no DOR antagonists are clinically approved. We thus expanded on our previous structure–activity relationship …

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Discovery of a novel non-toxic analog of clofarabine for the treatment of triple–negative breast cancer

Omar Moukha‐Chafiq, Rebecca J. Boohaker, Larry Bratton, Marina Fosso Yatchang et autres

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Synthesis and evaluation of novel substituted N-(2-phenylbutyl)-5,6,7,8-tetrahydro-quinazolin-4-amines as allosteric modulators of HIV-DAT-tat interaction

Theresa Nguyen, Omar Moukha‐Chafiq, Shuklendu D. Karyakarte, Ana Catya Jiménez-Torres et autres

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High-throughput screening for the identification of dual inhibitors of BRD4 and RIPK3 toward the development of small-molecule medical countermeasure agents against arsenicals

Marina Fosso Yatchang, Ling Zhai, Omar Moukha‐Chafiq, Bini Mathew et autres

Warfare arsenicals are potent blistering agents and cause severe inflammation following their skin exposure. Data from our group (unpublished) show that these chemicals act by activating bromodomain-4 and RIPK signaling. To develop a dual inhibitor of the bromodomain-containing protein 4 (BRD4) and …

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High-throughput screening for identification of influenza a inhibitors using a cell-based immunofluorescence assay

Yohanka Martinez-Gzegozewska, Lynn Rasmussen, N. Miranda Nebane, Sara McKellip et autres

A highly sensitive cell-based imaging assay has been used to screen a 200,000 compounds library for potential influenza antivirals. Compounds were screened at a concentration of 10 μM against the influenza strain A/Udorn/72 (H3N2) and the duplex capability of the assay was …

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Discovery of a Chiral 2,4-Substituted Pyrrolo[2,3-d]pyrimidine as a Potent, Selective, and Orally Bioavailable LRRK2 Inhibitor

Omar Moukha‐Chafiq, Tuyana Malankhanova, Jacob Valiyaveettil, Vandana V. Gupta et autres

Inhibition of leucine-rich repeat kinase (LRRK2) activity with small molecules has emerged as a potential novel therapeutic target for Parkinson’s disease (PD). We have previously reported the identification of SRI-29132 as a potent LRRK2 inhibitor, but the presence of a 6-thioether moiety, …

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Synthesis and Evaluation of Novel Substituted N-(2-phenylbutyl)-5,6,7,8-tetrahydro-quinazolin-4-amines as Allosteric Modulators of HIV-DAT-Tat Interaction

Omar Moukha‐Chafiq, Theresa Nguyen, Shuklendu D. Karyakarte, Ana Catya Jiménez-Torres et autres

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4-Substituted-2-Thiazole Amides as Viral Replication Inhibitors of Alphaviruses

Atefeh Garzan, S. Kaleem Ahmed, Nicole N. Haese, Gauthami Sulgey et autres

2-(Methylthio)- N -(4-(naphthalen-2-yl)thiazol-2-yl)nicotinamide 1 was identified as an inhibitor against Chikungunya virus (CHIKV) with good antiviral activity [EC 50 = 0.6 μM; EC 90 = 0.93 μM and viral titer reduction (VTR) of 6.9 logs at 10 μM concentration] with no observed …

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