Parthasaradhireddy Tanguturi

Efficacy Modulation and Structural Insights of Mu Opioid-Sparing Agents (Abstract ID: 231854)

Barnali Paul, Peng Huang, Nokomis Ramos-Gonzalez, Junzheng Wang et autres

us, cn (code pays fourni par la source)

Discovery and dynamic pharmacology of µ-opioid receptor positive allosteric modulators

Evan S. O'Brien, Junzheng Wang, Parthasaradhireddy Tanguturi, Mengchu Li et autres

Opioid agonists such as morphine and fentanyl exert analgesic effects by binding and activating the μ-opioid receptor (μOR), yet agonism of the μOR causes a slate of serious side effects. μOR-mediated addiction and respiratory depression are the major causes of the current …

us, cn, jp (code pays fourni par la source)

Brain Hsp90 Inhibition Mitigates Facial Allodynia in a Rat Model of CSD Headache and Upregulates Endocannabinoid Signaling in the PAG

Seph M. Palomino, Aidan A. Levine, Erika Liktor‐Busa, Parthasaradhireddy Tanguturi et autres

Background/Objectives: The role of the molecular chaperone heat shock protein 90 (Hsp90) in pain and analgesia has been recognized; however, no study to date has investigated its role in facial allodynia during headache. In the current study, we examined the role of …

us (code pays fourni par la source)

Development of Delta Opioid Receptor Antagonists Which Prevent Alzheimer’s Disease-Like Pathology in the 5X-Familial Alzheimer’s Disease [5XFAD] Mouse Model

Parthasaradhireddy Tanguturi, Stefanie Mitchell, Omar Moukha‐Chafiq, Sixue Zhang et autres

Alzheimer’s Disease is a growing health concern, with no available disease-modifying treatments. A previous report suggested that a Delta Opioid Receptor (DOR) antagonist could prevent Alzheimer’s-like pathology; however, no DOR antagonists are clinically approved. We thus expanded on our previous structure–activity relationship …

us, bg, fi (code pays fourni par la source)

Inhibiting spinal cord-specific hsp90 isoforms reveals a novel strategy to improve the therapeutic index of opioid treatment

David I. Duron, Parthasaradhireddy Tanguturi, Christopher S. Campbell, Kerry Chou et autres

Opioids are the gold standard for the treatment of chronic pain but are limited by adverse side effects. In our earlier work, we showed that Heat shock protein 90 (Hsp90) has a crucial role in regulating opioid signaling in spinal cord; Hsp90 …

us (code pays fourni par la source)

The role of opioid receptors in modulating Alzheimer’s Disease

Parthasaradhireddy Tanguturi, John M. Streicher

Alzheimer's disease (AD) is a complex neurological disorder characterized by accumulation of amyloid plaques and neurofibrillary tangles. Long term investigation of AD pathogenesis suggests that β-site amyloid precursor protein [APP] cleaving enzyme 1 (BACE1) and γ-secretase enzymes promote the amyloidogenic pathway and …

us (code pays fourni par la source)

Structure-Based Design of Glycosylated Oxytocin Analogues with Improved Selectivity and Antinociceptive Activity

Lajos Szabó, Parthasaradhireddy Tanguturi, Hannah J. Goodman, Sára Sprőber et autres

Acute and chronic pain is often treated with opioids despite the negative side effects of constipation, physical dependence, respiratory depression, and overdose. The misuse of opioid analgesics has given rise to the opioid crisis/epidemic, and alternate nonaddictive analgesics are urgently needed. Oxytocin, …

us, hu (code pays fourni par la source)

Design of Analgesic Trivalent Peptides with Low Withdrawal Symptoms: Probing the Antinociceptive Profile of Novel Linear and Cyclic Peptides as Opioid Pan Ligands

Azzurra Stefanucci, Paola Minosi, Stefano Pieretti, Parthasaradhireddy Tanguturi et autres

The discovery of efficacious and safe analgesics with reduced side effects is the foremost challenge in the pain field. In this work, we report the in vitro and in vivo evaluation of linear and cyclic analogues of biphalin with the aim to …

it, us (code pays fourni par la source)

Discovery of κ Opioid Receptor (KOR)-Selective d -Tetrapeptides with Improved In Vivo Antinociceptive Effect after Peripheral Administration

Azzurra Stefanucci, Alice Della Valle, Giuseppe Scioli, Lorenza Marinaccio et autres

Peripherally active tetrapeptides as selective κ opioid receptor (KOR) agonists have been prepared in good overall yields and high purity following solid-phase peptide synthesis via Fmoc protection strategy. Structural modifications at the first and second position of the lead compound FF( d …

it, hu, us (code pays fourni par la source)

Correction: Tanguturi et al. Discovery of Novel Delta Opioid Receptor (DOR) Inverse Agonist and Irreversible (Non-Competitive) Antagonists. Molecules 2021, 26, 6693

Parthasaradhireddy Tanguturi, Vibha Pathak, Sixue Zhang, Omar Moukha‐Chafiq et autres

There was an error in the original publication [...].

us (code pays fourni par la source)

Design and Synthesis of Brain Penetrant Glycopeptide Analogues of PACAP With Neuroprotective Potential for Traumatic Brain Injury and Parkinsonism

Christopher R. Apostol, Kelsey Bernard, Parthasaradhireddy Tanguturi, G Molnár et autres

There is an unmet clinical need for curative therapies to treat neurodegenerative disorders. Most mainstay treatments currently on the market only alleviate specific symptoms and do not reverse disease progression. The Pituitary adenylate cyclase-activating polypeptide (PACAP), an endogenous neuropeptide hormone, has been …

us, gb (code pays fourni par la source)

Genome-Wide CRISPR/Cas9-Based Screening for Deubiquitinase Subfamily Identifies Ubiquitin-Specific Protease 11 as a Novel Regulator of Osteogenic Differentiation

Kamini Kaushal, Apoorvi Tyagi, Janardhan Keshav Karapurkar, Eun‐Jung Kim et autres

The osteoblast differentiation capacity of mesenchymal stem cells must be tightly regulated, as inadequate bone mineralization can lead to osteoporosis, and excess bone formation can cause the heterotopic ossification of soft tissues. The balanced protein level of Msh homeobox 1 (MSX1) is …

kr (code pays fourni par la source)