Larry Bratton

Synthesis of novel 6-azacytidine prodrugs as potent influenza A inhibitors

Omar Moukha‐Chafiq, Larry Bratton, Shuklendu D. Karyakarte, Kathy A. Keith et autres

us (code pays fourni par la source)

Discovery of a novel non-toxic analog of clofarabine for the treatment of triple–negative breast cancer

Omar Moukha‐Chafiq, Rebecca J. Boohaker, Larry Bratton, Marina Fosso Yatchang et autres

us (code pays fourni par la source)

Data from Targeting the HuR Oncogenic Role with a New Class of Cytoplasmic Dimerization Inhibitors

Natalia Filippova, Xiuhua Yang, Subramaniam Ananthan, Jennifer Calano et autres

Abstract The development of novel therapeutics that exploit alterations in the activation state of key cellular signaling pathways due to mutations in upstream regulators has generated the field of personalized medicine. These first-generation efforts have focused on actionable mutations identified by deep …

us (code pays fourni par la source)

Supplementary Data File S3 from Targeting the HuR Oncogenic Role with a New Class of Cytoplasmic Dimerization Inhibitors

Natalia Filippova, Xiuhua Yang, Subramaniam Ananthan, Jennifer Calano et autres

File (samples Report Nabors 061019-2-top hits) provides proteomic annotated data for top hits after neurosphere treatment with SRI-42127 compound versus control for Fig. S13.

Supplementary Data File S2 from Targeting the HuR Oncogenic Role with a New Class of Cytoplasmic Dimerization Inhibitors

Natalia Filippova, Xiuhua Yang, Subramaniam Ananthan, Jennifer Calano et autres

File (tmp-LBN-Inhibitor vs DMSO DESeq2 annotated results with normalized counts) provides RNA-Seq annotated data for Fig. 6 and Table 1, which illustrate transcriptome analysis for PDGx neurospheres treated with SRI-42127 compound versus control.

Supplementary Data File S7 from Targeting the HuR Oncogenic Role with a New Class of Cytoplasmic Dimerization Inhibitors

Natalia Filippova, Xiuhua Yang, Subramaniam Ananthan, Jennifer Calano et autres

File (individual enrichment gene plots) provides enrichment gene plots at a high resolution for a summary of the gene ontology enrichment analysis illustrated in Fig. 6.

Supplementary Data from Targeting the HuR Oncogenic Role with a New Class of Cytoplasmic Dimerization Inhibitors

Natalia Filippova, Xiuhua Yang, Subramaniam Ananthan, Jennifer Calano et autres

Supplementary materials including tables, figures, and detailed methods.

us (code pays fourni par la source)

Supplementary Data File S5 from Targeting the HuR Oncogenic Role with a New Class of Cytoplasmic Dimerization Inhibitors

Natalia Filippova, Xiuhua Yang, Subramaniam Ananthan, Jennifer Calano et autres

File (tmp-LBN-Data-Kinase_Inhibition-050719) provides the kinase profiling data (10-point titration results, Scientific's SelectScreen{trade mark, serif} Kinase Profiling, Thermo Fisher) for SRI-41666 and SRI-42127 compounds for Fig. S4.

Supplementary Data File S6 from Targeting the HuR Oncogenic Role with a New Class of Cytoplasmic Dimerization Inhibitors

Natalia Filippova, Xiuhua Yang, Subramaniam Ananthan, Jennifer Calano et autres

File (tmp-LBN-Report_PH-DMPK-UAB-19-001_SRI-42127 _Mouse IP Plasma Brain PK) provides pharmacokinetic data for Fig. S14.

Supplementary Data File S1 from Targeting the HuR Oncogenic Role with a New Class of Cytoplasmic Dimerization Inhibitors

Natalia Filippova, Xiuhua Yang, Subramaniam Ananthan, Jennifer Calano et autres

File (DATA FILE S1 Lead optimization-SAR-Chemical compound synthesis-11-03-2020-SZ v4, pdf format 297 pages) provides a detailed and sequential description of the chemical synthesis of compounds evaluated in this study and a docking study for SRI-42127 compound with SRI-42127-binding sites at HuR.

Supplementary Data File S4 from Targeting the HuR Oncogenic Role with a New Class of Cytoplasmic Dimerization Inhibitors

Natalia Filippova, Xiuhua Yang, Subramaniam Ananthan, Jennifer Calano et autres

File (samples Report Nabors 061019-proteomics) provides proteomic data for neurospheres treated with SRI-42127 versus control for Fig. S13.

Supplementary Data File S7 from Targeting the HuR Oncogenic Role with a New Class of Cytoplasmic Dimerization Inhibitors

Natalia Filippova, Xiuhua Yang, Subramaniam Ananthan, Jennifer Calano et autres

File (individual enrichment gene plots) provides enrichment gene plots at a high resolution for a summary of the gene ontology enrichment analysis illustrated in Fig. 6.