Lynn Rasmussen

Synthesis of novel 6-azacytidine prodrugs as potent influenza A inhibitors

Omar Moukha‐Chafiq, Larry Bratton, Shuklendu D. Karyakarte, Kathy A. Keith et autres

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Acid-sensing ion channel 3 in macrophages, but not sensory neurons, mediates development of activity-induced muscle pain

Kazuhiro Hayashi, Joseph B. Lesnak, Ashley N. Plumb, Adam J. Janowski et autres

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Targeting west nile virus replication by xanthine inhibitors

Theresa Nguyen, Jessica R. Smith, Shuklendu D. Karyakarte, Fuad Al Abir et autres

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A high-throughput human tissue model for respiratory viruses: Automating the use of human airway epithelial tissues for faster drug discovery

N. Miranda Nebane, Andrew Reece, Lynn Rasmussen, Melinda Sosa et autres

Animal testing for drug discovery is expensive and the decision to test a compound in an in vivo model should be carefully considered. In addition, the FDA Modernization Act has resulted in the allowance of alternatives to animal models for testing the …

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High-throughput screening for identification of influenza a inhibitors using a cell-based immunofluorescence assay

Yohanka Martinez-Gzegozewska, Lynn Rasmussen, N. Miranda Nebane, Sara McKellip et autres

A highly sensitive cell-based imaging assay has been used to screen a 200,000 compounds library for potential influenza antivirals. Compounds were screened at a concentration of 10 μM against the influenza strain A/Udorn/72 (H3N2) and the duplex capability of the assay was …

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4-Substituted-2-Thiazole Amides as Viral Replication Inhibitors of Alphaviruses

Atefeh Garzan, S. Kaleem Ahmed, Nicole N. Haese, Gauthami Sulgey et autres

2-(Methylthio)- N -(4-(naphthalen-2-yl)thiazol-2-yl)nicotinamide 1 was identified as an inhibitor against Chikungunya virus (CHIKV) with good antiviral activity [EC 50 = 0.6 μM; EC 90 = 0.93 μM and viral titer reduction (VTR) of 6.9 logs at 10 μM concentration] with no observed …

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Pregabalin produces analgesia in males but not females in an animal model of chronic widespread muscle pain

Ashley N. Plumb, Kazuhiro Hayashi, Adam J. Janowski, Angela B. Smith et autres

Abstract Introduction: Pregabalin, which acts on the α2δ-1 subunit of voltage-gated calcium channels, relieves ≥50% of pain in a third of individuals with fibromyalgia. Thus far, preclinical studies of pregabalin have predominantly used male animals. Objectives: The purpose of our study was …

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Female specific interactions of serotonin and testosterone in the rostral ventromedial medulla after activity-induced muscle pain

Ashley N. Plumb, Joseph B. Lesnak, Lynn Rasmussen, Kathleen A. Sluka

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A high-throughput response to the SARS-CoV-2 pandemic

Lynn Rasmussen, S K Sanders, Melinda Sosa, Sara McKellip et autres

Four years after the beginning of the COVID-19 pandemic, it is important to reflect on the events that have occurred during that time and the knowledge that has been gained. The response to the pandemic was rapid and highly resourced; it was …

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A High-Throughput Human Tissue Model for Respiratory Viruses

Miranda Nebane, Andrew Reece, Lynn Rasmussen, Melinda Sosa et autres

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Development Of a Mouse Model for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Adam J. Janowski, Ashley N. Plumb, Kazuhiro Hayashi, Joseph B. Lesnak et autres

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High-Throughput cell-based immunofluorescence assays against influenza

Yohanka Martinez-Gzegozewska, Lynn Rasmussen, Sara McKellip, Anna Manuvakhova et autres

A rapid drug discovery response to influenza outbreaks with the potential to reach pandemic status could help minimize the virus's impact by reducing the time to identify anti-influenza drugs. Although several anti-influenza strategies have been considered in the search for new drugs, …

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