Imène Garali

The 12 o’clock assay: an optimized dodecaplex droplet digital PCR assay for robust DNA methylation quantification and epigenetic clock-based age-predictions

Ilef Hchaichi, Imène Garali, Alina-Madalina Popa, Antoine Daunay et autres

Abstract DNA methylation quantification in age-prediction models relies on only a few techniques with inherent limitations and biases, reducing the accuracy and reproducibility. We developed a new droplet digital PCR assay format for accurate DNA methylation quantification, based on three LNA-containing hydrolysis …

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Additional file 1 of The 12 o’clock assay: an optimized dodecaplex droplet digital PCR assay for robust DNA methylation quantification and epigenetic clock-based age-predictions

Ilef Hchaichi, Imène Garali, Alina-Madalina Popa, Antoine Daunay et autres

Supplementary Material 1.

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Additional file 1 of The 12 o’clock assay: an optimized dodecaplex droplet digital PCR assay for robust DNA methylation quantification and epigenetic clock-based age-predictions

Ilef Hchaichi, Imène Garali, Alina-Madalina Popa, Antoine Daunay et autres

Supplementary Material 1.

fr (code pays fourni par la source)

Effects of moderate doses of ionizing radiation on experimental abdominal aortic aneurysm

Goran Riazi, Chloe Brizais, Imène Garali, Rida Al-Rifai et autres

BACKGROUND: Exposure to ionizing radiation has been linked to cardiovascular diseases. However, the impact of moderate doses of radiation on abdominal aortic aneurysm (AAA) remains unknown. METHODS: Angiotensin II-infused Apoe-/- mice were irradiated (acute, 1 Gray) either 3 days before (Day-3) or …

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Improvements and inter-laboratory implementation and optimization of blood-based single-locus age prediction models using DNA methylation of the ELOVL2 promoter

Imène Garali, Mourad Sahbatou, Antoine Daunay, Laura G. Baudrin et autres

Several blood-based age prediction models have been developed using less than a dozen to more than a hundred DNA methylation biomarkers. Only one model (Z-P1) based on pyrosequencing has been developed using DNA methylation of a single locus located in the ELOVL2 …

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Alzheimer’s Disease Computer-Aided Diagnosis on Positron Emission Tomography Brain Images Using Image Processing Techniques

Mouloud Adel, Imène Garali, Xiaoxi Pan, Caroline Fossati et autres

Positron emission tomography (PET) is a molecular medical imaging modality which is commonly used for neurodegenerative disease diagnosis. Computer-aided diagnosis (CAD), based on medical image analysis, could help with the quantitative evaluation of brain diseases such as Alzheimer’s disease (AD). Ranking the …

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Histogram-Based Features Selection and Volume of Interest Ranking for Brain PET Image Classification

Imène Garali, Mouloud Adel, Salah Bourennane, Éric Guedj

Positron emission tomography (PET) is a molecular medical imaging modality which is commonly used for neurodegenerative diseases diagnosis. Computer-aided diagnosis, based on medical image analysis, could help quantitative evaluation of brain diseases such as Alzheimer's disease (AD). A novel method of ranking …

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A strategy for multimodal data integration: application to biomarkers identification in spinocerebellar ataxia

Imène Garali, Isaac Mawusi Adanyeguh, Farid Ichou, Vincent Perlbarg et autres

The growing number of modalities (e.g. multi-omics, imaging and clinical data) characterizing a given disease provides physicians and statisticians with complementary facets reflecting the disease process but emphasizes the need for novel statistical methods of data analysis able to unify these views. …

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Classification of positron emission tomography brain images using first and second derivative features

Imène Garali, Mouloud Adel, Salah Bourennane, Éric Guedj

Computer-Aided Diagnosis (CAD) for Positron Emission Tomography (PET) brain images is of importance for better quantifying and diagnosing neurodegenerative diseases like Alzheimer Disease (AD). This paper presents new features based on first and second derivatives, computed on brain PET images and aiming …

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Brain region ranking for 18FDG-PET computer-aided diagnosis of Alzheimer's disease

Imène Garali, Mouloud Adel, S. Bourennane, Eric Guedj

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一次および2次導関数特徴を用いた陽電子放出断層撮影脳画像の分類【Powered by NICT】

Imène Garali, Mouloud Adel, Salah Bourennane, Guedj Eric

Aide au diagnostic de la maladie d’Alzheimer par des techniques de sélection d’attributs pertinents dans des images cérébrales fonctionnelles obtenues par tomographie par émission de positons au 18FDG

Imène Garali

Dans le cadre de cette these, nous nous sommes interesses a l’etude de l’apport d’une aide assistee par ordinateur au diagnostic de certaines maladies degeneratives du cerveau, en explorant les images de tomographie par emission de positons, par des techniques de traitement …