Isaac Mawusi Adanyeguh

Short Echo‐Time Spiral MRSI Versus Single‐Voxel Spectroscopy in the Human Brain at 3 Tesla With Semi‐ LASER Localization

Young Woo Park, Isaac Mawusi Adanyeguh, Pierre‐Gilles Henry, Dinesh Kumar Deelchand

ABSTRACT Purpose Magnetic resonance spectroscopy techniques are widely used to non‐invasively study brain metabolism. Despite advances in magnetic resonance spectroscopic imaging (MRSI), there is a notable absence of research on comparing fast non‐Cartesian MRSI with single‐voxel spectroscopy (SVS), limiting our understanding of …

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A Severity‐Agnostic Atrophy Pattern in Spinocerebellar Ataxia Type 3: Volumetrics from ENIGMA ‐Ataxia

Jason W. Robertson, Isaac Mawusi Adanyeguh, David J. Arpin, Tetsuo Ashizawa et autres

BACKGROUND: Spinocerebellar ataxia type 3 (SCA3) is a rare, inherited neurodegenerative disease characterized by progressive loss of motor coordination. OBJECTIVES: We undertook a multisite magnetic resonance imaging study to profile the spatial spread of atrophy across the brain, determine whether atrophy preferentially …

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Brain Atrophy in Spinocerebellar Ataxia Type 1 (SCA1) across the Disease Course: MRI Volumetrics from ENIGMA-Ataxia

Jason W. Robertson, Isaac Mawusi Adanyeguh, Tetsuo Ashizawa, Benjamin Bender et autres

Abstract Objective Spinocerebellar ataxia type 1 (SCA1) is a rare, inherited neurodegenerative disease characterised by progressive deterioration of motor and cognitive function. Here, we illustrate the pattern and evolution of brain atrophy in people with SCA1 using a large multisite dataset. Methods …

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A Core Pattern of Cerebellar and Brainstem Degeneration and Reduced Cerebrocerebellar Structural Covariance in Spinocerebellar Ataxia Type 3 (SCA3): MRI Volumetrics from ENIGMA-Ataxia

Jason W. Robertson, Isaac Mawusi Adanyeguh, David J. Arpin, Tetsuo Ashizawa et autres

Abstract Objective Spinocerebellar ataxia type 3 (SCA3) is a rare, inherited neurodegenerative disease. Here, we profile the spatial spread of atrophy across the whole brain, determine whether brain degeneration preferentially maps onto specific functional networks, and investigate the relationship between cerebellar and …

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Automated Deep Learning–based Segmentation of the Dentate Nucleus Using Quantitative Susceptibility Mapping MRI

Diogo H. Shiraishi, Susmita Saha, Isaac Mawusi Adanyeguh, Sirio Cocozza et autres

A deep learning model using a two-step localization and segmentation pipeline accurately and reliably segmented the dentate nucleus using brain MRI–based quantitative susceptibility mapping images.

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Correction: A natural history study to track brain and spinal cord changes in individuals with Friedreich’s ataxia: TRACK-FA study protocol

Nellie Georgiou‐Karistianis, Louise A. Corben, Kathrin Reetz, Isaac Mawusi Adanyeguh et autres

[This corrects the article DOI: 10.1371/journal.pone.0269649.].

Neuroimaging Biomarkers for Friedreich Ataxia: A Cross‐Sectional Analysis of the TRACK ‐ FA Study

Nellie Georgiou‐Karistianis, Louise A. Corben, Eric F. Lock, Helena Bujalka et autres

OBJECTIVE: We aimed to quantify differences in the brain and spinal cord between Friedreich ataxia and controls, stratified by age and disease stage, including for the first time in young children. METHODS: TRACK-FA is the largest prospective, longitudinal, multi-modal neuroimaging study in …

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Correction: A natural history study to track brain and spinal cord changes in individuals with Friedreich’s ataxia: TRACK-FA study protocol

Nellie Georgiou‐Karistianis, Louise A. Corben, Kathrin Reetz, Isaac Mawusi Adanyeguh et autres

[This corrects the article DOI: 10.1371/journal.pone.0269649.].

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The Pattern and Stages of Atrophy in Spinocerebellar Ataxia Type 2: Volumetrics from ENIGMA ‐Ataxia

Jason W. Robertson, Isaac Mawusi Adanyeguh, Benjamin Bender, Sylvia Boesch et autres

BACKGROUND: Spinocerebellar ataxia type 2 (SCA2) is a rare, inherited neurodegenerative disease characterized by progressive deterioration in both motor coordination and cognitive function. Atrophy of the cerebellum, brainstem, and spinal cord are core features of SCA2; however, the evolution and pattern of …

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Effect of Triheptanoin on Caudate Atrophy and Motor Scores in Patients With Early-Stage Huntington Disease

Fanny Mochel, Aurélie Méneret, Isaac Mawusi Adanyeguh, Camille Giron et autres

BACKGROUND AND OBJECTIVES: Brain energy deficiency occurs at the early stage of Huntington disease (HD). Triheptanoin, a drug that targets the Krebs cycle, can restore a normal brain energetic profile in patients with HD. In this study, we aimed at assessing its …

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Image navigators insensitive to B0 inhomogeneity for optimal prospective motion-corrected MRS

Dinesh Kumar Deelchand, Isaac Mawusi Adanyeguh, Pierre‐Gilles Henry

Motivation: Navigator-based prospective motion-corrected MRS is often performed with 2nd order shims optimized in the whole brain to prevent degradation of navigator images, resulting in suboptimal linewidth. Goal(s): Here, we report image-based prospective motion correction with 2nd order shims adjusted in the …

The Pattern and Staging of Brain Atrophy in Spinocerebellar Ataxia Type 2 (SCA2): MRI Volumetrics from ENIGMA-Ataxia

Jason W. Robertson, Isaac Mawusi Adanyeguh, Benjamin Bender, Sylvia Boesch et autres

Abstract Objective Spinocerebellar ataxia type 2 (SCA2) is a rare, inherited neurodegenerative disease characterised by progressive deterioration in both motor coordination and cognitive function. Atrophy of the cerebellum, brainstem, and spinal cord are core features of SCA2, however the evolution and pattern …

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