J. Michael White

CD4+ T Cells Play Distinct Roles during the Priming versus Effector Phases of Immune Checkpoint Therapy–Dependent Tumor Elimination by CD8+ T Cells

Samuel Ameh, Derek J. Theisen, Mahima Thapa, Jackson S. Turner et autres

It is well established that CD4⁺ T cells play a critical role in facilitating immune checkpoint therapy (ICT). Although CD4+ T-cell function in lymph nodes during CD8⁺ T-cell priming has been well investigated, their requirement at the effector phase in the tumor …

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NUP98-rearranged pediatric AML is sustained by a conserved leukemia stem cell program with SPNS2/3 as a targetable vulnerability

Jihye Yoon, Elisabeth Denby, Wei Yang, Run Zhang et autres

Abstract Pediatric acute myeloid leukemias (AML) are genetically and molecularly diverse. Pediatric AML carry a range of different driver mutations, often including translocations that produce fusion oncoproteins. Furthermore, they arise from diverse progenitor cell populations and at different stages of fetal and …

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Fetal context conveys heritable protection against MLL-rearranged AML that depends on MLL3

Jonny Mendoza‐Castrejon, Wei Yang, Elisabeth Denby, Helen C. Wang et autres

ABSTRACT: MLL rearrangements (MLLrs) are the most common cause of congenital and infant leukemias. MLLrs arise prior to birth and can transform fetal/neonatal progenitors with the help of only a few additional cooperating mutations. Despite the low threshold for transformation, infant leukemias …

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Intraperitoneal Chemotherapy: A Call to Study Reproductive Safety for Healthcare Workers

Princy Gupta, Elizabeth Louise Godfrey, Kurt S. Schultz, Lumeng Jenny Yu et autres

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Fetal context conveys heritable protection against MLL-rearranged leukemia that depends on MLL3

Jonny Mendoza‐Castrejon, Wei Yang, Elisabeth Denby, Helen H. Wang et autres

ABSTRACT MLL rearrangements ( MLL r) are the most common cause of congenital and infant leukemias. MLL r arise prior to birth and require few cooperating mutations for transformation, yet congenital leukemias are 10-fold less common than infant leukemias and >100-fold less …

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Abstract B121: Personalized neoantigen vaccine-based therapies in syngeneic mouse models of lymphoma: Development of neoantigen-specific immunotherapies for mouse A20 lymphoma

Yuang Song, Hussein Sultan, Cora D. Arthur, J. Michael White et autres

Abstract Neoantigen vaccines represent a promising immunotherapeutic approach against cancer. Ongoing work from our lab and others has facilitated neoantigen discovery and neoantigen-specific immunotherapy design that can lead to the elimination of established tumors without inducing toxicity. While early personalized neoantigen vaccine …

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Fetal Differentiation Programs Afford a Protective Barrier to NUP98 Fusion-Driven AML That Dissipates Shortly after Birth

Jihye Yoon, Elisabeth Denby, Wei Yang, Emily B. Casey et autres

Mutations that drive pediatric acute myeloid leukemia (AML) are often age-restricted. NUP98 rearrangements (NUP98r) cause high-risk AML primarily in early-to-mid childhood. NUP98r are rare in adult AML. Furthermore, AML almost never occurs before birth, even though underlying translocations can occur prenatally. This …

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An ILC2-chitinase circuit restores lung homeostasis after epithelial injury

Haerin Jung, Do-Hyun Kim, Roberto Efraín Díaz, J. Michael White et autres

Environmental exposures increase the risk for severe lung disease, but specific drivers of persistent epithelial injury and immune dysfunction remain unclear. Here, we identify a feedback circuit triggered by chitin, a common component of airborne particles, that affects lung health after epithelial …

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Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy

Hussein Sultan, Yoshiko Takeuchi, Jeffrey P. Ward, Naveen Sharma et autres

. Yet, the nature and function of the latter remain unclear. Here, using vaccines containing MHC class I (MHC-I) neoantigens (neoAgs) and different doses of tumour-derived MHC-II neoAgs, we discovered that whereas the inclusion of vaccines with low doses of MHC-II-restricted peptides …

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Fetal MAVS and type I IFN signaling pathways control ZIKV infection in the placenta and maternal decidua

Yael Alippe, Leran Wang, Reyan Coskun, Stéfanie Primon Muraro et autres

The contribution of placental immune responses to congenital Zika virus (ZIKV) syndrome remains poorly understood. Here, we leveraged a mouse model of ZIKV infection to identify mechanisms of innate immune restriction exclusively in the fetal compartment of the placenta. ZIKV principally infected …

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Lrp1 is essential for lethal Rift Valley fever hepatic disease in mice

Madeline M. Schwarz, Safder S. Ganaie, Annie Feng, G. Schuyler Brown et autres

Rift Valley fever virus (RVFV) is an emerging arbovirus found in Africa. While RVFV is pantropic and infects many cells and tissues, viral replication and necrosis within the liver play a critical role in mediating severe disease. The low-density lipoprotein receptor-related protein …

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Supplementary Figure 5 from Strain-Specific Variation in Murine Natural Killer Gene Complex Contributes to Differences in Immunosurveillance for Urethane-Induced Lung Cancer

Daniel Kreisel, Andrew E. Gelman, Ryuji Higashikubo, Xue Lin et autres

PDF file - 76K, Microsatellite mapping of the 129/SvEv.B6-NKC Rag2-/- mouse