Safder S. Ganaie

CRISPR Screen in mouse BV2 cells against RVFV

Gaya Amarasinghe, Safder S. Ganaie, Amy L. Hartman, Daisy W. Leung

STARS file from the original data analysis

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CRISPR Screen in mouse BV2 cells against RVFV

Gaya Amarasinghe, Safder S. Ganaie, Amy L. Hartman, Daisy W. Leung

STARS file from the original data analysis

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SNX17 Facilitates Entry and Infection of Rift Valley Fever Virus and Related Bunyaviruses

Safder S. Ganaie, Farheen Fatma, Zhengzheng Hu, Marco Grodzki et autres

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LRP1 facilitates Jamestown Canyon virus infection of neurons

Zachary D. Frey, David Anthony Price, Kaleigh A. Connors, Rachael E. Rush et autres

Jamestown Canyon virus (JCV) is a bunyavirus and arbovirus that causes viral neuroinvasive disease in North America. JCV neuropathogenesis is understudied, and no pro-viral host factors for cellular infection have been identified. Here, we assessed the role of low-density lipoprotein receptor-related protein …

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Lrp1 facilitates infection of neurons by Jamestown Canyon virus

Zachary D. Frey, David Anthony Price, Kaleigh A. Connors, Rachael E. Rush et autres

Jamestown Canyon virus (JCV) is a bunyavirus and arbovirus responsible for neuroinvasive disease in the United States. Little is known about JCV pathogenesis, and no host factors required for cellular infection have been identified. Recently, we identified low-density lipoprotein receptor related protein …

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Lrp1 is essential for lethal Rift Valley fever hepatic disease in mice

Madeline M. Schwarz, Safder S. Ganaie, Annie Feng, G. Schuyler Brown et autres

Rift Valley fever virus (RVFV) is an emerging arbovirus found in Africa. While RVFV is pantropic and infects many cells and tissues, viral replication and necrosis within the liver play a critical role in mediating severe disease. The low-density lipoprotein receptor-related protein …

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Editorial: Virus-induced innate immune response and inflammation

Safder S. Ganaie, Zekun Wang, Bin Su, Sheema Mir

EDITORIAL article Front. Microbiol., 06 June 2023Sec. Virology Volume 14 - 2023 | https://doi.org/10.3389/fmicb.2023.1213270

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Host entry factors of Rift Valley Fever Virus infection

Safder S. Ganaie, Daisy W. Leung, Amy L. Hartman, Gaya K. Amarasinghe

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Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site

Vera J. E. van Vliet, Nhan Huynh, Judith Palà, Ankoor Patel et autres

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has made it clear that combating coronavirus outbreaks benefits from a combination of vaccines and therapeutics. A promising drug target common to all coronaviruses-including SARS-CoV, MERS-CoV, and SARS-CoV-2-is the papain-like protease (PLpro). PLpro …

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Rift Valley Fever Virus Infects the Posterior Segment of the Eye and Induces Inflammation in a Rat Model of Ocular Disease

Madeline M. Schwarz, Kaleigh A. Connors, Katherine Anne Davoli, Cynthia M. McMillen et autres

Rift Valley fever virus (RVFV) infection leads to eye damage in humans in up to 10% of reported cases. Permanent blindness occurs in 50% of individuals with significant retinal scarring. Despite the prevalence and severity of this outcome, very little is known …

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Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1

Madeline M. Schwarz, David Anthony Price, Safder S. Ganaie, Annie Feng et autres

) is a mosquito-transmitted virus that causes widespread human febrile illness in South America, with occasional progression to neurologic effects. Host factors mediating the cellular entry of OROV are undefined. Here, we show that OROV uses the host protein low-density lipoprotein-related protein …

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Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1

Madeline M. Schwarz, David Anthony Price, Safder S. Ganaie, Annie Feng et autres

Abstract Oropouche orthobunyavirus (OROV; Peribunyaviridae ) is a mosquito-transmitted virus that causes widespread cases of human febrile illness in South America, with occasional progression to neurologic effects. Host entry factors mediating cellular entry of OROV are undefined. Here, we show that OROV …

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