Hussein Sultan

Personalized Neoantigen Vaccines Synergize with Immune Checkpoint Therapy and CD8-Targeted Cytokines to Control B-Cell Lymphoma

Yuang Song, Ekaterina Aladyeva, Ruan F. Vieira Medrano, Derek J. Theisen et autres

ABSTRACT Personalized neoantigen (neoAg) vaccines have shown clinical promise in solid tumors 1–8 , yet their efficacy and mechanism of action in hematopoietic malignancies remain poorly defined 9–11 . Herein, we establish an immunocompetent syngeneic A20 B-cell lymphoma platform to test the …

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CD4+ T Cells Play Distinct Roles during the Priming versus Effector Phases of Immune Checkpoint Therapy–Dependent Tumor Elimination by CD8+ T Cells

Samuel Ameh, Derek J. Theisen, Mahima Thapa, Jackson S. Turner et autres

It is well established that CD4⁺ T cells play a critical role in facilitating immune checkpoint therapy (ICT). Although CD4+ T-cell function in lymph nodes during CD8⁺ T-cell priming has been well investigated, their requirement at the effector phase in the tumor …

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Supplementary Table S2 from IL2 Targeted to CD8+ T Cells Promotes Robust Effector T-cell Responses and Potent Antitumor Immunity

Kelly Dare Moynihan, Manu P. Kumar, Hussein Sultan, Danielle C. Pappas et autres

Supplementary Table S2, Antibodies used in this study

Supplementary Table S1 from IL2 Targeted to CD8+ T Cells Promotes Robust Effector T-cell Responses and Potent Antitumor Immunity

Kelly Dare Moynihan, Manu P. Kumar, Hussein Sultan, Danielle C. Pappas et autres

Supplementary Table S1, Molecules used in this study

Figure S1 from Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry

Wei Meng, Yoshiko Takeuchi, Jeffrey P. Ward, Hussein Sultan et autres

Optimal FAIMS CV(s) improve the identification of 8–12-mer H-2Kb- or H-2Db-restricted peptides.

Figure S3 from Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry

Wei Meng, Yoshiko Takeuchi, Jeffrey P. Ward, Hussein Sultan et autres

Optimal FAIMS CV(s) improve the coverage of I-Ab restricted peptides.

Figure S8 from Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry

Wei Meng, Yoshiko Takeuchi, Jeffrey P. Ward, Hussein Sultan et autres

F244 neoantigen tetramer staining and neoantigen targeting vaccines in F244 bearing mice.

Supplementary Figure S9 from IL2 Targeted to CD8+ T Cells Promotes Robust Effector T-cell Responses and Potent Antitumor Immunity

Kelly Dare Moynihan, Manu P. Kumar, Hussein Sultan, Danielle C. Pappas et autres

Supplementary Figure S9: scRNAseq analysis of MC38 tumors.

Figure S5 from Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry

Wei Meng, Yoshiko Takeuchi, Jeffrey P. Ward, Hussein Sultan et autres

1956 MHC-I and -II neoantigen prediction and screens.

Figure S7 from Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry

Wei Meng, Yoshiko Takeuchi, Jeffrey P. Ward, Hussein Sultan et autres

F244 MHC-I and -II neoantigen prediction and screens.

Supplementary Figure S10 from IL2 Targeted to CD8+ T Cells Promotes Robust Effector T-cell Responses and Potent Antitumor Immunity

Kelly Dare Moynihan, Manu P. Kumar, Hussein Sultan, Danielle C. Pappas et autres

Supplementary Figure S10: In vitro and in vivo activity of AB248 in cynomolgus monkey.

Figure S6 from Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry

Wei Meng, Yoshiko Takeuchi, Jeffrey P. Ward, Hussein Sultan et autres

Psmd6 and Cs sequences in 1956 subclones.