Marie‐Michelle Genois

Targeting the DNA replication stress phenotype of KRAS mutant cancer cells

Tara Al Zubaidi, O. H. Fiete Gehrisch, Marie‐Michelle Genois, Qi Liu et autres

Mutant KRAS is a common tumor driver and frequently confers resistance to anti-cancer treatments such as radiation. DNA replication stress in these tumors may constitute a therapeutic liability but is poorly understood. Here, using single-molecule DNA fiber analysis, we first characterized baseline …

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Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies

Jiamin Zhang, Marie‐Michelle Genois, Jian Ouyang, Li Lan et autres

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CARM1 regulates replication fork speed and stress response by stimulating PARP1

Marie‐Michelle Genois, Jean‐Philippe Gagné, Takaaki Yasuhara, Jessica Jackson et autres

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ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop

Dominick A. Matos, Jiamin Zhang, Jian Ouyang, Hai Dang Nguyen et autres

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Erratum: Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination

David Moquin, Marie‐Michelle Genois, Jiamin Zhang, Jian Ouyang et autres

Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination

David Moquin, Marie‐Michelle Genois, Jiamin Zhang, Jian Ouyang et autres

with RAD18 leads to localized protein biotinylation at DNA damage sites, allowing identification of ZPET (zinc finger protein proximal to RAD eighteen)/ZNF280C as a potential DNA damage response (DDR) protein. ZPET binds ssDNA and localizes to DNA double-strand breaks (DSBs) and stalled …

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ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells

Stephanie A. Yazinski, Valentine Comaills, Rémi Buisson, Marie‐Michelle Genois et autres

Poly-(ADP-ribose) polymerase (PARP) inhibitors (PARPis) selectively kill BRCA1/2-deficient cells, but their efficacy in BRCA-deficient patients is limited by drug resistance. Here, we used derived cell lines and cells from patients to investigate how to overcome PARPi resistance. We found that the functions …

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The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice

Ismail Hassan Ismail, Jean‐Philippe Gagné, Marie‐Michelle Genois, Hilmar Strickfaden et autres

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Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum

Marie‐Michelle Genois, Marie Plourde, Chantal Éthier, Gaétan Roy et autres

To achieve drug resistance Leishmania parasite alters gene copy number by using its repeated sequences widely distributed through the genome. Even though homologous recombination (HR) is ascribed to maintain genome stability, this eukaryote exploits this potent mechanism driven by the Rad51 recombinase …

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Rôles de la recombinaison homologue dans la résistance aux drogues chez le parasite "Leishmania"

Marie‐Michelle Genois

Bien que l’on attribue généralement un effet néfaste à l’instabilité génomique, pour le parasite Leishmania, elle s’avère pourtant bénéfique. De façon étonnante, ce protozoaire possède la capacité de remanier le nombre de copies de ses gènes pour s’adapter à son environnement et …

Formation of Linear Amplicons with Inverted Duplications in Leishmania Requires the MRE11 Nuclease

Marie-Claude N. Laffitte, Marie‐Michelle Genois, Angana Mukherjee, Danielle Légaré et autres

Extrachromosomal DNA amplification is frequent in the protozoan parasite Leishmania selected for drug resistance. The extrachromosomal amplified DNA is either circular or linear, and is formed at the level of direct or inverted homologous repeated sequences that abound in the Leishmania genome. …

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DNA Repair Pathways in Trypanosomatids: from DNA Repair to Drug Resistance

Marie‐Michelle Genois, Éric R. Paquet, Marie-Claude N. Laffitte, Ranjan Maity et autres

All living organisms are continuously faced with endogenous or exogenous stress conditions affecting genome stability. DNA repair pathways act as a defense mechanism, which is essential to maintain DNA integrity. There is much to learn about the regulation and functions of these …

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