Angana Mukherjee

Functional validation of the Plasmodium falciparum K13 C580Y mutation in recently collected Ethiopian isolates

Angana Mukherjee, Ashenafi Bahita Assefa, Christopher V. Turlo, Lisa Checkley Needham et autres

ABSTRACT Recent genomic investigation in Ethiopia identified the first detection of the Plasmodium falciparum Kelch13 (K13) C580Y substitution in the Horn of Africa. To assess its functional impact, we introduced C580Y into two recently collected Ethiopian clinical isolates using CRISPR-Cas9 genome editing. …

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ERK signaling promotes IKKε expression and oncogenic functions in pancreatic cancer cells in association with TBK1

Kirsten Bryant, Laura Herring, Thomas Webb, Albert Baldwin et autres

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Experimental evolution and functional genetics identify KIC1 as a determinant of reduced artemisinin susceptibility in Bangladeshi Plasmodium falciparum

Maisha Khair Nima, Nirjhar Bhattacharyya, Saiful Arefeen Sazed, Ching Swe Phru et autres

ABSTRACT Bangladesh has greatly reduced malaria transmission, but persistent Plasmodium falciparum transmission in the Chittagong Hill Tracts (CHT), bordering Myanmar, remains a concern for elimination. Emerging artemisinin resistance could threaten remaining control efforts, making it important to identify determinants of reduced artemisinin …

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FOXI3 promotes migration and proliferation in prostate cancer bone metastases, modulated by FGF8

Angana Mukherjee, Daniel P. Hollern, William A. Byrd, Tyeler S Rayburn et autres

ABSTRACT Studies have shown that all men who die from prostate cancer exhibit bone involvement, highlighting the clinical significance of bone metastases. Previously, we demonstrated that prostate cancer exhibits elevated expression of FOXI3; a transcription factor critical to bone development. However, its …

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ERK signaling promotes IKKε expression and oncogenic functions in pancreatic cancer cells in association with TBK1

Adam C. Graves, Angana Mukherjee, Runying Y. Yang, Angie L. Mordant et autres

A variety of cancers utilize RAS-regulated signaling pathways to promote oncogenic phenotypes. A widely studied example is pancreatic cancer, where mutant KRAS signaling leads to activation of MEK (mitogen-activated protein kinase/extracellular signal-regulated kinase [ERK])-ERK and downstream signaling, which promotes oncogenic mechanisms, including …

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Globally prevalent Kelch13 mutations increase partial artemisinin resistance and fitness in Bangladeshi Plasmodium falciparum parasites

Maisha Khair Nima, Nirjhar Bhattacharyya, Jung E. Park, Douglas A. Shoue et autres

Abstract Artemisinin partial resistance (ArtR), mediated by Kelch13 (K13) gene mutations in Plasmodium falciparum , has caused delayed parasite clearance and, together with partner drug resistance, treatment failures in the Greater Mekong Subregion (GMS). The Chittagong Hill Tracts (CHTs), located in southeastern …

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DAB2IP Loss in Luminal A Breast Cancer Leads to NF-kB Associated Aggressive Oncogenic Phenotypes

Sarah C. Van Alsten, Daniel P. Hollern, Philip M. Spanheimer, Tyler Laws et autres

Despite proven therapy options for estrogen receptor (ER)-positive breast tumors, a substantial number of ER+ cancer patients exhibit relapse with associated metastasis. Loss of expression of RasGAPs leads to poor outcomes in several cancers, including breast cancer. Mining the TCGA breast cancer …

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DAB2IP loss in luminal a breast cancer leads to NF-κB–associated aggressive oncogenic phenotypes

Angana Mukherjee, Rasha T. Kakati, Sarah C. Van Alsten, Tyler Laws et autres

Despite proven therapy options for estrogen receptor-positive (ER+) breast tumors, a substantial number of patients with ER+ breast cancer exhibit relapse with associated metastasis. Loss of expression of RasGAPs leads to poor outcomes in several cancers, including breast cancer. Mining the The …

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A Plasmodium falciparum genetic cross reveals the contributions of pfcrt and plasmepsin II/III to piperaquine drug resistance

John W Kane, Xue Li, Sudhir Kumar, Katrina A. Button-Simons et autres

ABSTRACT Piperaquine (PPQ) is widely used in combination with dihydroartemisinin as a first-line treatment against malaria. Multiple genetic drivers of PPQ resistance have been reported, including mutations in the Plasmodium falciparum chloroquine resistance transporter ( pfcrt ) and increased copies of plasmepsin …

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Suicide Prevention Policy in India: Reflections by Mental Health Professionals

VaniB Kulhalli, Srilatha Juvva, Angana Mukherjee, Bhagyadeep Dhakre et autres

The National Suicide Prevention Strategy was launched by India on November 21, 2022. It was the first step toward making suicide prevention a public health priority with the aim of a 10% reduction in suicide mortality by 2030. The present article incorporates …

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Assessment of Plasmodium falciparum Artemisinin Resistance Independent of kelch13 Polymorphisms and with Escalating Malaria in Bangladesh

Maisha Khair Nima, Angana Mukherjee, Saiful Arefeen Sazed, Muhammad Riadul Haque Hossainey et autres

Malaria elimination is a Millennium Development Goal. Artemisinins, fast-acting antimalarial drugs, have played a key role in malaria elimination. Emergence of artemisinin resistance threatens the global elimination of malaria. Over the last decade, advanced clinical and laboratory methods have documented its spread …

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A Phosphoinositide-Binding Protein Acts in the Trafficking Pathway of Hemoglobin in the Malaria Parasite Plasmodium falciparum

Angana Mukherjee, Marie‐Ève Crochetière, Audrey Sergerie, Souad Amiar et autres

Malaria represents an enormous burden for a significant proportion of humanity, and the lack of vaccines and problems with drug resistance to all antimalarials demonstrate the need to develop new therapeutics. Inhibitors of phosphoinositide metabolism are currently being developed as antimalarials but …

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