Chantal Éthier

Asparaginase activity levels and toxicity in children and adolescents with acute lymphoblastic leukemia

Marie‐Claude Pelland‐Marcotte, Chantal Éthier, Alexis Manirakiza, Héloïse Perrault et autres

Asparaginase (ASP) is a critical treatment component of acute lymphoblastic leukemia (ALL), yet associated with potentially severe complications. We assessed whether serum asparaginase activity (SAA) is associated with development of venous thrombosis, acute pancreatitis, bleeding and/or hypersensitivity events. We included 84 patients …

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Clinical outcomes following catheter-related venous thrombo-embolism among children with acute lymphoblastic leukemia

Marie-Claude Pelland-Marcotte, Thai Hoa Tran, Chantal Éthier, Camille Beaulieu et autres

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Incidence and Risk Factors of Serious Osteonecrosis in Pediatric Acute Lymphoblastic Leukemia: A CYP‐C Population‐Based Study

Noémie de Villiers, Chantal Éthier, Caroline Laverdière, Nathalie Alos et autres

BACKGROUND: Osteonecrosis (ON) is a debilitating complication of acute lymphoblastic leukemia (ALL) therapy. While numerous studies have explored its incidence and associated risk factors, investigations using large-scale cohorts remain important to characterize ON across heterogeneous populations. Objectives were to describe the incidence …

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Safety and effectiveness of standard versus extended duration of anticoagulation in children with acute lymphoblastic leukemia and venous thrombo-embolism

Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran, Chantal Éthier, Camille Beaulieu et autres

Abstract Background Venous thrombo-embolism (VTE) occurs in up to 10% of pediatric patients with acute lymphoblastic leukemia (ALL). While anticoagulation is the mainstay of treatment, the optimal duration of therapeutic and/or prophylactic anticoagulation remains unclear. Aims To compare VTE progression/recurrence and bleeding …

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Long-term impact of central venous catheters in pediatric cancer survivors

Tasha Cusson, Émilie Martineau, Chantal Éthier, André P. Lamarre et autres

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Impact of Obesity and Overweight on Heparin Dosing and Clinical Outcomes in Pediatric Patients with Venous Thromboembolism

Alain Larouche, Valérie Dollo, Gabriel M. Mercier, Narcisse Singbo et autres

Abstract Dosing guidance for anticoagulation, the mainstay of venous thromboembolism (VTE) treatment, is lacking for obese children. We aimed to compare unfractionated heparin (UFH) and low-molecular-weight heparins (LMWH) dosing requirements and clinical outcomes between obese/overweight and nonobese children. This monocentric retrospective cohort …

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Impact of Obesity on Anticoagulation Dosing and Clinical Outcomes in Pediatric Patients with Venous Thrombo-Embolism

Marie‐Claude Pelland‐Marcotte, Alain Larouche, Valérie Dollo, Gabriel M. Mercier et autres

Background:Venous thromboembolism (VTE) and obesity are both dramatically increasing among all pediatric age groups. Dosing guidance for anticoagulation in children with obesity remains uncertain even though nearly 20% of Canadian children are deemed obese, despite possible pharmacokinetics differences. Aims:Between obese and non-obese …

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Clinical Significance of Incidental Central Venous Catheter-Related Thrombosis in Children Previously Treated for Cancer

Marie‐Claude Pelland‐Marcotte, Tasha Cusson, Émilie Martineau, Chantal Éthier et autres

Background: Up to 50% of children with cancer may develop clinically unsuspected venous thrombo-embolisms (VTE), most related to an underlying central venous catheter (CVC). Whether clinically unsuspected and symptomatic VTEs are associated with similar long-term clinical impacts in children with cancer is …

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Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks

Marie‐Christine Caron, Ajit Kumar Sharma, Julia A. O’Sullivan, Logan R. Myler et autres

PARP-1 is rapidly recruited and activated by DNA double-strand breaks (DSBs). Upon activation, PARP-1 synthesizes a structurally complex polymer composed of ADP-ribose units that facilitates local chromatin relaxation and the recruitment of DNA repair factors. Here, we identify a function for PARP-1 …

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Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum

Marie‐Michelle Genois, Marie Plourde, Chantal Éthier, Gaétan Roy et autres

To achieve drug resistance Leishmania parasite alters gene copy number by using its repeated sequences widely distributed through the genome. Even though homologous recombination (HR) is ascribed to maintain genome stability, this eukaryote exploits this potent mechanism driven by the Rad51 recombinase …

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Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs

Jean‐Philippe Gagné, Chantal Éthier, Daniel Defoy, Sylvie Bourassa et autres

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Reprogramming cellular events by poly(ADP-ribose)-binding proteins

Jana Krietsch, Michèle Rouleau, Émilie Pic, Chantal Éthier et autres

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