Julian Esteban Muñoz

Antimicrobial Peptides Act-6 and Act 8-20 Derived from Scarabaeidae Cecropins Exhibit Differential Antifungal Activity

Melissa Rodríguez, Lily Johanna Toro, Carolina Firacative, Beatriz L. Gómez et autres

The number of fungal infections is steadily increasing, with considerable morbidity and mortality. Additionally, antifungal resistance is a growing concern, highlighting the need to develop new treatment options. One alternative is the use of antimicrobial peptides (AMPs). The aim of this study …

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Virulence of Candida spp. Isolates From Patients With Recurrent Vulvovaginal Candidosis Is Associated With the Number of Episodes

Jeiser Marcelo Consuegra‐Asprilla, F Elizabeth Taborda, Verónica Pérez, Brajhan Torres et autres

BACKGROUND: Recurrent vulvovaginal candidosis (RVVC) has been associated with increased antifungal resistance. Recently, we reported that Candida isolates from Colombian patients with RVVC did not show an increase in antifungal resistance. OBJECTIVE: The aim of this study was to evaluate the virulence …

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Identificacion de polimorfismos en el gen mieloperoxidasa y su papel en candidiasis vulvovaginal recurrente por Candida spp., aisladas de pacientes de Bogota DC

María Paula Montoya, Gloria Julieth Rincón, Julian Esteban Muñoz, Sharon Hassbleidy Ochoa et autres

Introduction: Myeloperoxidase (MPO) is an antimicrobial protein present in the azuro- philic granules of neutrophils, its action falls when it is conjugated in the phagosome with hydrogen peroxide, resulting in toxic substances for phagocytosed microorganisms. Seve- ral authors have described that recurrent …

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Therapeutic Use of the Antimicrobial Peptide PNR20 to Resolve Disseminated Candidiasis in a Murine Model

Jeisson Micelly-Moreno, Adriana Barreto-Santamaría, Gabriela Arévalo‐Pinzón, Carolina Firacative et autres

Invasive fungal infections (IFIs) caused by Candida species are an emerging threat globally, given that patients at-risk and antifungal resistance are increasing. Antimicrobial peptides (AMPs) have shown good therapeutic capacity against different multidrug-resistant (MDR) microorganisms. This study evaluated the activity of the …

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In Vitro Antifungal Activity of Three Synthetic Peptides against Candida auris and Other Candida Species of Medical Importance

Richar Torres, Adriana Barreto-Santamaría, Gabriela Arévalo‐Pinzón, Carolina Firacative et autres

Candidiasis is an opportunistic infection affecting immunosuppressed and hospitalized patients, with mortality rates approaching 40% in Colombia. The growing pharmacological resistance of Candida species and the emergence of multidrug-resistant Candida auris are major public health problems. Therefore, different antimicrobial peptides (AMPs) are …

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Editorial: Tropical fungal diseases

Carlos Pelleschi Taborda, Julian Esteban Muñoz, Angel R Gonzalez

Tropical fungal diseasesThe tropical region of Earth occurs between the latitude lines of the Tropic of Cancer and the Tropic of Capricorn.The tropics include parts of North America, South America, Africa, Asia, and Australia (Figure 1).The climate in the tropics is characterized …

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In Vitro Antifungal Activity of LL-37 Analogue Peptides against Candida spp.

Gladys Pinilla, Yenifer Tatiana Coronado, Gabriel Chaves, Liliana Muñoz et autres

Fungal infections have increased in recent decades with considerable morbidity and mortality, mainly in immunosuppressed or admitted-to-the-ICU patients. The fungal resistance to conventional antifungal treatments has become a public health problem, especially with Candida that presents resistance to several antifungals. Therefore, generating …

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P070 Antimicrobial peptides from the Coleoptera family Scarabaeidae against Candida and Cryptococcus pathogenic yeasts.

Lily Johanna Toro, Melissa Rodríguez, Beatriz L. Gómez, Carolina Firacative et autres

Abstract Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM Objectives Host defense peptides (HDP) are produced by a diversity of beetles. The aims of this work were (1) to find new promising peptides from the Coleoptera family Scarabaeidae with …

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Development and evaluation of antimicrobial peptides from the Scarabaeidae coleopteran family against pathogenic yeasts with public health impact.

Julian Esteban Muñoz, Beatriz L. Gómez, Carolina Firacative, David Andreu et autres

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Repositioning Lopinavir, an HIV Protease Inhibitor, as a Promising Antifungal Drug: Lessons Learned from Candida albicans—In Silico, In Vitro and In Vivo Approaches

André Luis Souza dos Santos, Lys Adriana Braga-Silva, Diego de Souza Gonçalves, Lívia S. Ramos et autres

The repurposing strategy was applied herein to evaluate the effects of lopinavir, an aspartic protease inhibitor currently used in the treatment of HIV-infected individuals, on the globally widespread opportunistic human fungal pathogen Candida albicans by using in silico, in vitro and in …

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The secreted acid trehalase encoded by the CgATH1 gene is involved in Candida glabrata virulence

Rafael Garcia Lopes, Julian Esteban Muñoz, Ludmila M Barros, Sérgio Luiz Alves Júnior et autres

BACKGROUND Candida glabrata yeast is the second cause of candidiasis worldwide. Differs from other yeasts since assimilates only glucose and trehalose (a characteristic used in rapid identification tests for this pathogen) by secreting into the medium a highly active acid trehalase encoded …

Actividad antifúngica in vitro de péptidos análogos derivados de LL-37 contra levaduras del género Candida

Wendy Daniela Mejia, Karem Guzmán, Gladys Pinilla, Andrea Cruz et autres

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