Carolina Firacative

Progressive Structural Failure in Complex Prosthetic Joint Infection Followed by Amputation

Alejandro Rodriguez-Bobadilla, Andrés Pinzón-Susa, Esteban Hernández-Alfonso, Liseth Katherine Peralta et autres

Background: Prosthetic joint infections (PJI) are complex complications of arthroplasty. Detailed sequential polymicrobial infection during long clinical courses, with multiple interventions and sustained antibiotic pressure, has been described sparingly. Methods: We present a case of a 78-year-old woman with various comorbidities, including …

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First case report of onychomycosis caused by Exophiala alcalophila

Lili Rueda-Jaime, Leticia Sopó-Prada, Carolina Firacative

ABSTRACT A 46-year-old woman from Colombia, without any medical comorbidities, presented with marked yellowish discoloration of both big toenails, suggestive of onychomycosis, and malalignment of the nail plate. Culture of nail scrapings grew dark-pigmented, mucoid, yeast-like colonies identified as Exophiala alcalophila by …

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Cryptococcosis in the Apparently Immunocompetent: A Shifting Landscape?

Carolina Firacative, Andrés Cendales-Regalado, Óscar Gil, Carlos Morales Pertuz

To comprehensively review clinical, diagnostic, and therapeutic data on the global epidemiology of cryptococcosis in apparently immunocompetent patients with no or only a few minor medical conditions who were previously healthy. While cryptococcosis is often regarded as a rare presentation in presumably …

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Wild-type MIC distributions and epidemiological cut-off values for ibrexafungerp, manogepix, and rezafungin against WHO fungal priority pathogens

Maria J. Morelo, Carolina Firacative, Guillermo Garcia-Effron, Beatriz L. Gómez et autres

OBJECTIVE: This study gathered public data regarding the in vitro activity of three novel antifungal agents, ibrexafungerp, manogepix, and rezafungin, against the fungi listed in the WHO fungal priority pathogens list. METHODS: Epidemiological cut-off values (ECVs/ECOFFs) were established for species with sufficient …

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Novel cyp51A mutation profile in Aspergillus fumigatus from a patient with systemic lupus erythematosus and limited systemic sclerosis: first clinical case of acquired azole-resistance in Colombia

Carlos Morales-Pertuz, Miguel Ángel VANEGAS, Ximena Castañeda-Luquerna, Eliana Maldonado et autres

BACKGROUND: Aspergillus fumigatus is a saprophytic filamentous fungus that causes infection mostly in patients with underlying diseases, including those that alter the immune system. Despite progress in the diagnosis and treatment of this mycosis, mortality remains very high, particularly after hematogenous spread. …

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The Antimicrobial Peptide C14R Is Active Against All Pathogenic Species of the ESKAPE Group

Daniel Gruber, Verena Vogel, Jan-Christoph Walter, Grigory Bolotnikov et autres

The global rise in antimicrobial resistance among the ESKAPE pathogens represents a major challenge to public health. Here, we report the broad-spectrum antibacterial activity of the synthetic antimicrobial and pore-forming peptide C14R against all six ESKAPE species. Using a radial diffusion assay …

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Phage Display-Derived Peptides Have Neutralizing Activities Against Biofilm Formation by Candida albicans, Candidozyma auris and Candida parapsilosis

Grigory Bolotnikov, Daniel Gruber, Jan-Christoph Walter, Kim Kühnel et autres

Background/Objectives: Infections caused by Candida albicans, Candidozyma auris, and Candida parapsilosis increasingly challenge current treatment options as resistance to currently used antifungals is continuously developing. Neutralizing antimicrobial peptides (nAMPs), which modulate pathogenic behavior rather than inducing cell death, represent a promising approach …

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Emerging fluconazole-resistant Candida parapsilosis in Australia: a case cluster and insights into the genetic diversity of this species

Manoshi Perera, Winkie Fong, Rose Haywood, Geraldine J. Sullivan et autres

Background Nosocomial outbreaks of fluconazole-resistant Candida parapsilosis are concerning. Here we characterised a cluster of fluconazole-resistant C. parapsilosis utilising whole-genome sequencing (WGS) and correlate phenotypic azole resistance with resistome-based WGS analysis of azole resistance-conferring mutations. Materials and methods Seventeen C. parapsilosis isolates …

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Bad bugs, new drugs: The antimicrobial peptide C14R is active against the ESKAPE pathogens

Daniel Gruber, Verena Vogel, Sabine Szunerits, Armando Rodríguez et autres

Abstract The global rise of antimicrobial resistance among the ESKAPE pathogens represents a major challenge to public health. Here, we report the broad-spectrum antibacterial activity of the synthetic antimicrobial and pore-forming peptide C14R against all six ESKAPE species. Using a radial diffusion …

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Amyloid fibrils of the Als5p-derived peptide NH 2 -SNGIVIVATTRTV-COOH influence the biofilm formation of Candida albicans by shape-edging microcolony morphology

Daniel Gruber, Grigory Bolotnikov, Benedikt Miegel, Elisabeth Bierla et autres

Candida species are major contributors to nosocomial infections, with biofilm formation being a critical virulence factor that enables persistence in clinical settings and resistance to antifungal therapies. Central to biofilm development is the adhesion of fungal cells, a process mediated by surface …

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In vitro evaluation of Ibrexafungerp against clinical and environmental isolates of cryptococcus neoformans and cryptococcus gattii

Andrés Ceballos-Garzón, Carolina Firacative

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Antimicrobial Peptides Act-6 and Act 8-20 Derived from Scarabaeidae Cecropins Exhibit Differential Antifungal Activity

Melissa Rodríguez, Lily Johanna Toro, Carolina Firacative, Beatriz L. Gómez et autres

The number of fungal infections is steadily increasing, with considerable morbidity and mortality. Additionally, antifungal resistance is a growing concern, highlighting the need to develop new treatment options. One alternative is the use of antimicrobial peptides (AMPs). The aim of this study …

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