Gabriela Arévalo‐Pinzón

Plasmodium vivax cysteine-rich protective antigen (PvCyRPA), an important element for vaccine strategies targeting P. vivax, interacts with human erythrocyte surface

José Cebrián-Carmona, Gabriela Arévalo‐Pinzón, Adriana Barreto-Santamaría, Daniel E Gutiérrez-Ortegón et autres

Plasmodium vivax is one of the six species of the Plasmodium genus causing malaria in humans; furthermore, it is the species having the widest worldwide distribution. Despite causing a substantial health burden, progress in developing targeted interventions against P. vivax has been …

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Taxonomic and functional profile of the anorectal microbiota in HIV‐positive and HIV‐negative men who have sex with men, using a metagenomic approach

Paula Natalia Hernández‐Trujillo, Camila Andrea Lopez‐Barón, Gabriela Arévalo‐Pinzón, Martha Liliana Trujillo‐Güiza et autres

INTRODUCTION: The study of bacterial diversity in human samples is crucial for developing biomarkers of health and disease. This research characterized the taxonomic and functional diversity of the anorectal bacterial microbiota in men who hae sex with men (MSM) with HIV compared …

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Nota Editorial volumen 23, número 1

Claudia Pons, Alejandra Garrido, Gabriela Arévalo‐Pinzón

Este número de la revista EJS contiene una colección de artículos seleccionados de las52 JAIIO. Los artículos publicados en este número son versiones ampliadas y revisadas de trabajos presentados en el congreso, que fueron cuidadosamente evaluados por comités de expertos.

Therapeutic Use of the Antimicrobial Peptide PNR20 to Resolve Disseminated Candidiasis in a Murine Model

Jeisson Micelly-Moreno, Adriana Barreto-Santamaría, Gabriela Arévalo‐Pinzón, Carolina Firacative et autres

Invasive fungal infections (IFIs) caused by Candida species are an emerging threat globally, given that patients at-risk and antifungal resistance are increasing. Antimicrobial peptides (AMPs) have shown good therapeutic capacity against different multidrug-resistant (MDR) microorganisms. This study evaluated the activity of the …

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Babesia bovis RON2 binds to bovine erythrocytes through a highly conserved epitope

Laura Cuy-Chaparro, Danny Barney-Borrero, Gabriela Arévalo‐Pinzón, César Reyes et autres

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Invasion-inhibitory peptides chosen by natural selection analysis as an antimalarial strategy

Kewin Rodríguez-Obediente, Yoelis Yepes-Pérez, Daniel Benavides-Ortiz, Diana Díaz-Arévalo et autres

Plasmodium vivax's biological complexity has restricted in vitro culture development for characterising antigens involved in erythrocyte invasion and their immunological relevance. The murine model is proposed as a suitable alternative in the search for therapeutic candidates since Plasmodium yoelii uses homologous proteins …

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In Vitro Antifungal Activity of Three Synthetic Peptides against Candida auris and Other Candida Species of Medical Importance

Richar Torres, Adriana Barreto-Santamaría, Gabriela Arévalo‐Pinzón, Carolina Firacative et autres

Candidiasis is an opportunistic infection affecting immunosuppressed and hospitalized patients, with mortality rates approaching 40% in Colombia. The growing pharmacological resistance of Candida species and the emergence of multidrug-resistant Candida auris are major public health problems. Therefore, different antimicrobial peptides (AMPs) are …

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Antiviral activity of myricetin glycosylated compounds isolated from Marcetia taxifolia against Chikungunya virus

Ana Luisa Muñoz, Andrés F. Cuellar-Quimbaya, Gabriela Arévalo‐Pinzón, B. Santamaría et autres

analysis. Cytotoxicity of compounds was determined by MTT assay and viral load was assessed in cell substrates supernatants by plaque-forming and RT-qPCR assays. Selected molecules were analyzed by molecular docking assays. Myricetin 3-rhamnoside (MR) and myricetin 3-(6-rhamnosylgalactoside) (MRG) were tested for antiviral …

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Plasmodium falciparum rhoptry neck protein 4 has conserved regions mediating interactions with receptors on human erythrocytes and hepatocyte membrane

Fredy A. Pulido-Quevedo, Gabriela Arévalo‐Pinzón, Jeimmy Johana Castañeda-Ramírez, Adriana Barreto-Santamaría et autres

Plasmodium falciparum-related malaria represents a serious worldwide public health problem due to its high mortality rates. P. falciparum expresses rhoptry neck protein 4 (PfRON4) in merozoite and sporozoite rhoptries, it participates in tight junction-TJ formation via the AMA-1/RON complex and is refractory …

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Identification of Babesia bovis MSA-1 functionally constraint regions capable of binding to bovine erythrocytes

Laura Cuy-Chaparro, Laura Alejandra Ricaurte-Contreras, Michel David Bohórquez, Gabriela Arévalo‐Pinzón et autres

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P002 Antifungal activity of antimicrobial synthetic peptides against Candida species of public health importance

Richar Torres, Adriana Barreto-Santamaría, Gabriela Arévalo‐Pinzón, Patricia Escandón et autres

Abstract Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM Background Candidiasis is one of the most frequent opportunistic infections in immunosuppressed and/or hospitalized patients. In countries like Colombia, candidiasis is associated with a mortality rate of ∼ 46%. Growing …

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Estudio de interacciones hospedero-patógeno y proteína-proteína en Plasmodium Vivax : evaluación de las proteínas del cuello de optrias -2, -4 y -5 y del antígeno apical de membrana-1

Gabriela Arévalo‐Pinzón

La malaria es una de las enfermedades tropicales transmitidas por vectores más importantes a nivel mundial, donde Plasmodium vivax representa una de las especies más ampliamente distribuidas, afectando ~13.8 millones de personas por año. Pese a ello, el progreso aparentemente lento de …