Stephanie C. Koch

Naturalistic climbing reveals adaptive strategies for interlimb coordination in freely moving mice

Christopher J. Black, Marco Beato, Liam E. Browne, Robert M. Brownstone et autres

Multi-limb coordination is vital for mammalian locomotion. While coordination requires reliable organization of limb movements, it also requires flexibility to adapt to environmental demands. In natural settings, animals must navigate diverse terrains that impose unique challenges. Climbing, for example, introduces constraints due …

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Postnatal development of somatosensory corticospinal projections in the mouse lumbar spinal cord

Antonia Maria Constantinescu, Lorenzo Fabrizi, Stephanie C. Koch

Abstract Corticospinal projections from the primary somatosensory cortex (S1) form a distinct descending pathway that engages spinal dorsal horn circuits and modulates sensory processing. Despite advances in our understanding of the role of this pathway in the adult, the postnatal maturation of …

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Antisense oligonucleotides reverse SPTLC1-related hereditary sensory neuropathy in a mouse model

Jinhong Meng, Shuang‐Gang Ma, Museer A. Lone, Hou Wang Lam et autres

Hereditary sensory neuropathy type IA (HSN1A) is a rare neurodegenerative condition caused by dominant mutations in the Serine Palmitoyl Transferase Long Chain base subunit 1 (SPTLC1) gene. There is no treatment available. Allele-specific silencing by antisense oligonucleotides (ASOs) to preferentially silence the …

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Discrete and sequential critical periods organise the development of task-specific sensorimotor circuits in mice

Laura Andreoli, Antonia Maria Constantinescu, Christopher J Black, Stephanie C. Koch

Abstract Somatosensory circuits in early life must maintain stable, task-selective pathways while behavioural repertoires undergo rapid change. How such circuits construct these behaviours under evolving functional demands has remained unclear. Here we show that sensorimotor behaviours are shaped through sequential, experience-dependent critical …

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Ethologically relevant behavioural assay for investigating reach and grasp kinematics during whole-body motor control in mice

Christopher J. Black, Liam E. Browne, Robert M. Brownstone, Stephanie C. Koch

Abstract Reach and grasp are critical components of skilled mammalian motor control and their detailed analysis in rodents has been key to deepening our understanding of prehension in the context of health and disease. However, most studies investigating these behaviours focus on …

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Microglial Refinement of A-Fiber Projections in the Postnatal Spinal Cord Dorsal Horn Is Required for Normal Maturation of Dynamic Touch

Yajing Xu, Stephanie C. Koch, Alexander G. Chamessian, Qianru He et autres

Sensory systems are shaped in postnatal life by the refinement of synaptic connectivity. In the dorsal horn of the spinal cord, somatosensory circuits undergo postnatal activity-dependent reorganization, including the refinement of primary afferent A-fiber terminals from superficial to deeper spinal dorsal horn …

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Reliability and short version of the Dunphy Outcomes Framework (DOF): Integrating the art and science of dance movement therapy

Kim Dunphy, Paula Lebre, Ella Dumaresq, S.A. Schoenenberger-Howie et autres

There is an increasing requirement of evidence-based outcome frameworks in the health sciences. This article presents the Dunphy Outcomes Framework (DOF) for dance movement therapy (DMT), the first generic outcomes framework for DMT. The framework is posited to measure outcomes intrinsic to …

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The neuronal cell types of the spinal cord

Stephanie C. Koch, Ariel J. Levine

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List of contributors

Victoria E. Abraira, Miriam Aceves, Claudia Angeli, Cynthia Mary Arokiaraj et autres

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Author Correction: A harmonized atlas of mouse spinal cord cell types and their spatial organization

Daniel E. Russ, Ryan B. Patterson Cross, Li Li, Stephanie C. Koch et autres

The original version of this Article contained an error in Fig. 3A, in which one label ‘Excit-21’ was inadvertently duplicated instead of the correct label ‘Excit-31’, and another label ‘Excit-32’ was inadvertently omitted, from the right hand side of the panel. This …

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Author Correction: A harmonized atlas of mouse spinal cord cell types and their spatial organization

Daniel E. Russ, Ryan B. Patterson Cross, Li Li, Stephanie C. Koch et autres

The original HTML version of this Article did not link to Supplementary Tables 1 to 8 . This has been corrected in the HTML version of the article.

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Prolonged storage of purified granulocyte concentrates: Introduction of a new purification method

Gerd Klinkmann, Fanny Doß, Lilia Goudeva, Sandra Doß et autres

Abstract Background Use of donor granulocyte concentrate (GC) has been limited due to its short storage time of 6–24 h, which is partially due to residual red blood cells (RBCs) and platelets and the resulting lactate production leading to an acidotic milieu. …

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