Accès ouvert
2024
article
OpenAlex
Gerd Klinkmann, Fanny Doß, Sandra Doß, Antje Schwarz et autres
Background: Granulocyte concentrates (GCs) are usually prepared by single-donor apheresis after G-CSF pretreatment and have to be transfused within 24 h after cell collection because of the rapid decrease in pH and cell survival due to high lactate production by red blood …
de
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Accès ouvert
2023
article
OpenAlex
Gerd Klinkmann, T. Cameron Wild, Benjamin Heskamp, Fanny Doß et autres
BACKGROUND: Immune cell dysfunction is a central part of immune paralysis in sepsis. Granulocyte concentrate (GC) transfusions can induce tissue damage via local effects of neutrophils. The hypothesis of an extracorporeal plasma treatment with granulocytes is to show beneficial effects with fewer …
de
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Accès ouvert
2022
article
OpenAlex
Gerd Klinkmann, T. Cameron Wild, Benjamin Heskamp, Fanny Doß et autres
BACKGROUND: Immune cell dysfunction plays a central role in sepsis-associated immune paralysis. The transfusion of healthy donor immune cells, i.e., granulocyte concentrates (GC) potentially induces tissue damage via local effects of neutrophils. Initial clinical trials using standard donor GC in a strictly …
de
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Accès ouvert
2021
article
OpenAlex
Gerd Klinkmann, Fanny Doß, Lilia Goudeva, Sandra Doß et autres
Abstract Background Use of donor granulocyte concentrate (GC) has been limited due to its short storage time of 6–24 h, which is partially due to residual red blood cells (RBCs) and platelets and the resulting lactate production leading to an acidotic milieu. …
de
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2018
article
OpenAlex
Martin Sauer, Georg Richter, Jens Altrichter, T. Cameron Wild et autres
A granulocyte bioreactor for the extracorporeal treatment was developed to enhance the immune cell function in patients with severe sepsis. The influence of oxygenation on the used cells was tested in a prospective clinical study. Ten patients with severe sepsis were treated …
de
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Accès ouvert
2017
article
OpenAlex
Sandra Doß, H. Potschka, Fanny Doß, Steffen R Mitzner et autres
Purpose.Drug-induced liver injury (DILI) is the most common cause of liver injury and a serious clinical problem; antimycotics are involved in approximately 3% of all DILI cases. The hepatotoxicity of many drugs, including the antimycotics, is poorly screened in human models.Methods.In a …
de
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Accès ouvert
2016
article
OpenAlex
Martin Sauer, Jens Altrichter, Cristof Haubner, Annette Pertschy et autres
Purpose. Granulocyte transfusions have been used to treat immune cell dysfunction in sepsis. A granulocyte bioreactor for the extracorporeal treatment of sepsis was tested in a prospective clinical study focusing on the dosage of norepinephrine in patients and influence on dynamic and …
de
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2015
article
OpenAlex
Sandra Doß, H. Potschka, Fanny Doß, Steffen Mitzner et autres
de
(code pays fourni par la source)
2007
article
OpenAlex
Fanny Doß, Joël Ménard, Matthias Hauschild, Hans‐Jürgen Kreutzer et autres
OBJECTIVE: To analyse the levels of interleukin-6 (IL-6) in the synovial fluids and sera of patients with osteoarthritis (OA) and to identify the IL-6-secreting cells. METHODS: Serum, synovial fluid, synovial tissue, and articular cartilage samples were collected from 49 OA patients with …
hr, de, tw
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1979
article
OpenAlex
Fanny Doß
Weight gain in schizophrenic patients during chemotherapy was first reported with chlorpromazine. Since then other antipsychotic drugs have exhibited this effect, while some have reduced weight. A retrospective review of 78 schizophrenic patients revealed that thiothixene, fluphenazine, haloperidol, and thioridazine produced a …