Miriam Aceves

Transcriptomic Architecture of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Risk in Mexican Americans

Satish Kumar, Miriam Aceves, Lorena Guerra, Jose Granados et autres

Hispanics of Mexican American descent in South Texas show a very high prevalence of MASLD, with some studies reporting rates as high as 50% in adults. However, assessment of genetic risk factors underlying this prevalence is complicated by a high co-occurrence of …

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Functional synaptic connectivity of engrafted spinal cord neurons with hindlimb motor circuitry in the injured spinal cord

Ashley Tucker, Angelina Baltazar, Jaclyn T. Eisdorfer, Joshua K. Thackray et autres

Spinal cord injury (SCI) results in significant neurological deficits, and curative therapies are lacking. Neural progenitor cell (NPC) transplantation shows promise, as graft-derived neurons (GDNs) can integrate into host spinal cord and support axon regeneration. Here, we examined the synaptic integration of …

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Functional synaptic connectivity of engrafted spinal cord neurons with locomotor circuitry in the injured spinal cord

Ashley Tucker, Angelina Baltazar, Jaclyn T. Eisdorfer, Joshua K. Thackray et autres

Spinal cord injury (SCI) results in significant neurological deficits, with no currently available curative therapies. Neural progenitor cell (NPC) transplantation has emerged as a promising approach for neural repair, as graft-derived neurons (GDNs) can integrate into the host spinal cord and support …

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Neurocellular Stress Response to Mojave Type A Rattlesnake Venom: Study of Molecular Mechanisms Using Human iPSC-Derived Neural Stem Cell Model

Satish Kumar, Miriam Aceves, José A. Tapia Granados, L. García Guerra et autres

The Mojave rattlesnake venom shows significant geographical variability. The venom of Type A animals primarily contains β-neurotoxin referred to as Mojave Toxin (MTX), which makes bites from this snake particularly feared. We performed a genome-wide transcriptomic analysis of the neurocellular response to …

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Role of Neurocellular Endoplasmic Reticulum Stress Response in Alzheimer’s Disease and Related Dementias Risk

Miriam Aceves, José A. Tapia Granados, André Cesar Leandro, Juan M. Peralta et autres

Currently, more than 55 million people around the world suffer from dementia, and Alzheimer’s Disease and Related Dementias (ADRD) accounts for nearly 60–70% of all those cases. The spread of Alzheimer’s Disease (AD) pathology and progressive neurodegeneration in the hippocampus and cerebral …

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Pre-Infection Innate Immunity Attenuates SARS-CoV-2 Infection and Viral Load in iPSC-Derived Alveolar Epithelial Type 2 Cells

Satish Kumar, José A. Tapia Granados, Miriam Aceves, Juan M. Peralta et autres

A large portion of the heterogeneity in coronavirus disease 2019 (COVID-19) susceptibility and severity of illness (SOI) remains poorly understood. Recent evidence suggests that SARS-CoV-2 infection-associated damage to alveolar epithelial type 2 cells (AT2s) in the distal lung may directly contribute to …

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Publisher Correction: Developmental stage of transplanted neural progenitor cells influences anatomical and functional outcomes after spinal cord injury in mice

Miriam Aceves, Ashley Tucker, Joseph Chen, Katie D. Vo et autres

In this article the affiliation details for Andrew Buxton were incorrectly given as ‘Ganado High School, Ganado, TX 77962, USA’ but should have been ‘Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA’. The original article has been corrected.

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Developmental stage of transplanted neural progenitor cells influences anatomical and functional outcomes after spinal cord injury in mice

Miriam Aceves, Ashley Tucker, Joseph Chen, Katie D. Vo et autres

Abstract Neural progenitor cell (NPC) transplantation is a promising therapeutic strategy for replacing lost neurons following spinal cord injury (SCI). However, how graft cellular composition influences regeneration and synaptogenesis of host axon populations, or recovery of motor and sensory functions after SCI, …

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Spinal interneurons and cell transplantation

Ashley Tucker, Miriam Aceves, Jessica C. Butts, Jennifer N. Dulin

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List of contributors

Victoria E. Abraira, Miriam Aceves, Claudia Angeli, Cynthia Mary Arokiaraj et autres

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Transcription Factor Hb9 Is Expressed in Glial Cell Lineages in the Developing Mouse Spinal Cord

Sunjay Letchuman, Ashley Tucker, Diego Miranda, Robert L. Adkins et autres

Abstract Hb9 (Mnx1) is a transcription factor described as a spinal cord motor neuron (MN)-specific marker and critical factor for the postmitotic specification of these cells. To date, expression of Hb9 in other cell types has not been reported. We performed a …

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Effects of biological sex mismatch on neural progenitor cell transplantation for spinal cord injury in mice

Michael Pitonak, Miriam Aceves, Prakruthi Amar Kumar, Gabrielle Dampf et autres

Despite advancement of neural progenitor cell transplantation to spinal cord injury clinical trials, there remains a lack of understanding of how biological sex of transplanted cells influences outcomes after transplantation. To address this, we transplanted GFP-expressing sex-matched, sex-mismatched, or mixed donor cells …

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