Brian McDonnell

Diversity and prevalence of dairy streptococcal phages in two European dairy fermentation facilities over a one-year period

Kelsey White, Joanna Danuta Szafran, Brian McDonnell, Gargee Chawande et autres

Bacteriophages (or phages) represent a major challenge to industrial dairy fermentations and may cause reduced acidification of the milk substrate. Streptococcus thermophilus is a thermophilic lactic acid bacterium widely used in dairy fermentations. Here, we sought to establish the presence and diversity …

ie, it (code pays fourni par la source)

Structural investigation of polysaccharides extracted from four Bifidobacterium breve strains

Evgeny V. VINOGRADOV, Irina Sadovskaya, Brian McDonnell, Keith Coughlan et autres

Bifidobacterium breve is a common component of the human gut microbiota, particularly in infancy. Its surface-exposed polysaccharides may be important for its purported health-promoting activities and may serve various functions such as immune evasion and modulation, environmental stress protection, or carbohydrate substrate …

ca, fr, ie (code pays fourni par la source)

Raw Milk Cheese Microbiomes: A Paradigm for Interactions of Lactic Acid Bacteria in Food Ecosystems

Christine Olupot, Olivia Sheehan, Zoe Kampff, Brian McDonnell et autres

While industrial-scale dairy fermentations often employ pasteurized milk as the substrate, many farmhouse and traditional production practices apply raw milk derived from a variety of mammals. Certain artisanal production systems rely on the autochthonous microbiota of the milk, fermentation vessels, equipment and/or …

ie, it (code pays fourni par la source)

Research on Preterm Birth Prevention: The Participant Experience

Gillian A. Corbett, Lucy Eldersveld Murphy, Emma Hokey, Maggie O ́Brien et autres

BACKGROUND: Research on spontaneous preterm birth (sPTB) is deeply important to the patients it serves. There is an absence of the patient's voice on the experience of research participation. MATERIALS/METHODS: This prospective mixed-method study examined the experience of participants of a preterm …

ie (code pays fourni par la source)

Raw Milk Cheese Microbiomes: A Paradigm for Interactions of Lactic Acid Bacteria in Food Ecosystems

Christine Olupot, Olivia Sheehan, Zoe Kampff, Brian McDonnell et autres

While industrial scale dairy fermentations often employ pasteurized milk as the substrate, many farmhouse and traditional production practices apply raw milk derived from a variety of mammals. Certain artisanal production systems rely on the autochthonous microbiota of the milk, fermentation vessels, equipment …

ie, it (code pays fourni par la source)

The cell surface-associated rhamnose-glucose polysaccharide represents the receptor of Streptococcus thermophilus bacteriophage P738

Zoe Kampff, Irina Sadovskaya, Evgeny V. VINOGRADOV, Brian McDonnell et autres

ABSTRACT Streptococcus thermophilus is a key lactic acid bacterial species extensively used in dairy fermentations, where bacteriophage (phage) infections pose a significant threat to production efficiency. While the cell surface receptors for four of the five currently known streptococcal phage genera have …

ie, fr, ca (code pays fourni par la source)

EAT-lancet Planetary Health Diet improves pregnancy outcome for women at high-risk of spontaneous preterm birth

Gillian A. Corbett, Lucy Eldersveld Murphy, Brian McDonnell, Sophie Callanan et autres

ie (code pays fourni par la source)

Lactococcal mobile genetic elements harbour a diverse phage defensome rich in restriction-modification systems

Brian McDonnell, Philip Kelleher, Alexey I. Fomenkov, Guillermo Ortíz Charneco et autres

The genomes of 43 distinct lactococcal strains were reconstructed by a combination of long- and short-read sequencing, resolving the plasmid complement and methylome of these strains. The genomes comprised 43 chromosomes of approximately 2.5 Mb each and 269 plasmids ranging from 2 …

ie, us, fr, ch (code pays fourni par la source)

Preconceptual care reduces risk of spontaneous preterm birth for select high‐risk populations: A prospective study

Gillian A. Corbett, Larissa Luethe, Aoife McEvoy, M. A. O'Brien et autres

OBJECTIVE: Prevention of preterm birth (PTB) is an urgent unmet clinical need. Preconceptual counseling for women at high-risk of PTB offers a unique opportunity to mitigate risk of preterm birth for subsequent pregnancy. The present study aimed to examine the impact of …

ie (code pays fourni par la source)

Lactococcal phage–host profiling through binding studies between cell wall polysaccharide types and Skunavirus receptor-binding proteins

Kelsey D. White, Giovanni Eraclio, Brian McDonnell, Gabriele Andrea Lugli et autres

Dairy fermentations using mesophilic starter cultures rely on the activity of specific lactic acid bacteria (LAB) such as Lactococcus lactis and Lactococcus cremoris for the acidification of milk. This biotechnological process can be affected by bacteriophage infection of LAB starter strains, which …

ie, it, fr (code pays fourni par la source)

Phage defence loci of Streptococcus thermophilus—tip of the anti-phage iceberg?

Philip Kelleher, Guillermo Ortíz Charneco, Zoe Kampff, Natalia Díaz‐Garrido et autres

Bacteria possess (bacterio)phage defence systems to ensure their survival. The thermophilic lactic acid bacterium, Streptococcus thermophilus, which is used in dairy fermentations, harbours multiple CRISPR-Cas and restriction and modification (R/M) systems to protect itself against phage attack, with limited reports on other …

ie, it, us, fr, ch (code pays fourni par la source)

Discovery of antiphage systems in the lactococcal plasmidome

Andriana Grafakou, Cas Mosterd, Matthias H. Beck, Philip Kelleher et autres

Until the late 2000s, lactococci substantially contributed to the discovery of various plasmid-borne phage defence systems, rendering these bacteria an excellent antiphage discovery resource. Recently, there has been a resurgence of interest in identifying novel antiphage systems in lactic acid bacteria owing …

ie, nl, fr (code pays fourni par la source)