Gabriele Andrea Lugli

Long-term in vitro evolution of human-associated bifidobacteria provides insights into genome-based strain delineation

Gabriele Andrea Lugli, Chiara Argentini, Giulia Longhi, Leonardo Mancabelli et autres

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Function‐centered back‐tracing refines obesity‐associated gut microbiome signals beyond abundance‐based profiling

Silvia Petraro, Chiara Tarracchini, Leonardo Mancabelli, Gabriele Andrea Lugli et autres

By integrating taxonomic and functional profiling of 1543 adult gut metagenomes, this study identified microbial taxa and enzymatic functions associated with increasing Body Mass Index. Function-centered taxonomic back-tracing of branched-chain amino acid transaminase, nucleotide diphosphatase, and phosphatidylserine decarboxylase revealed only limited overlap …

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Genome-scale insights into the metabolic landscape and evolutionary development of Bifidobacterium bifidum

Emanuele Selleri, Giulia Longhi, Chiara Tarracchini, Erica De Carolis et autres

Background: Bifidobacterium bifidum (B. bifidum) is an infant gut symbiont specialized in degrading host-derived glycans. Despite its relevance in early life, the species’ genomic diversity has not yet been comprehensively surveyed, and current reference collections capture only a fraction of the global …

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Mucin O-glycan degradation by GH101 underpins mucosal persistence of Bifidobacterium bifidum PRL2010

Aryanna Muscò, Giulia Longhi, Emanuele Selleri, Emma Gennaioli et autres

Abstract Host-derived mucin O-glycans constitute a key chemical component of the human intestinal niche and are continuously encountered by gut-adapted bifidobacterial cells, thereby playing a pivotal role in host–microbe interactions. Among these microbes, Bifidobacterium bifidum is one of the most persistent members …

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Fecal calprotectin and gut microbiome in a cohort without intestinal pathologies from northern Italy

Giuseppe Taurino, Leonardo Mancabelli, Christian Milani, Giulia Longhi et autres

Fecal calprotectin is a biomarker for intestinal inflammatory conditions, while specific taxa of gut microbiota are proposed as biomarkers for inflammatory bowel disease. However, the relationship between microbiota and calprotectin levels is still largely unexplored. Using shallow shotgun metagenomics, we investigate microbial …

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Diversity and prevalence of dairy streptococcal phages in two European dairy fermentation facilities over a one-year period

Kelsey White, Joanna Danuta Szafran, Brian McDonnell, Gargee Chawande et autres

Bacteriophages (or phages) represent a major challenge to industrial dairy fermentations and may cause reduced acidification of the milk substrate. Streptococcus thermophilus is a thermophilic lactic acid bacterium widely used in dairy fermentations. Here, we sought to establish the presence and diversity …

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Raw Milk Cheese Microbiomes: A Paradigm for Interactions of Lactic Acid Bacteria in Food Ecosystems

Christine Olupot, Olivia Sheehan, Zoe Kampff, Brian McDonnell et autres

While industrial-scale dairy fermentations often employ pasteurized milk as the substrate, many farmhouse and traditional production practices apply raw milk derived from a variety of mammals. Certain artisanal production systems rely on the autochthonous microbiota of the milk, fermentation vessels, equipment and/or …

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Metagenomic assemble genomes for the study "Genome-scale insights into the metabolic landscape and evolutionary development of Bifidobacterium bifidum"

Emanuele Selleri, Gabriele Andrea Lugli, Marco Ventura

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Metagenomic assemble genomes for the study "Genome-scale insights into the metabolic landscape and evolutionary development of Bifidobacterium bifidum"

Emanuele Selleri, Gabriele Andrea Lugli, Marco Ventura

it (code pays fourni par la source)

Unveiling the genetic landscape and motility-associated functions of Type IV pili in the Bifidobacterium genus

Gabriele Andrea Lugli, Emanuele Selleri, Chiara Tarracchini, Aryanna Muscò et autres

Background: Bifidobacteria are recognized as one of the most influential bacterial groups inhabiting the human gut, capable of modulating the host’s health. To understand how these bacteria interact with their hosts, it is essential to investigate their extracellular structures, such as pili. …

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Assessment of genome evolution in Bifidobacterium adolescentis indicates genetic adaptation to the human gut

Emanuele Selleri, Chiara Tarracchini, Silvia Petraro, Leonardo Mancabelli et autres

ABSTRACT Bifidobacterium adolescentis is one of the most frequently encountered bifidobacterial species present in the adult human gut microbiota, with a prevalence of approximately 60%. Despite its high prevalence, B. adolescentis has not been extensively studied and characterized, and our understanding of …

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Microbial BioRemediation Database: A Comprehensive Database of Genes Involved in Microbial Bioremediation Processes

Silvia Petraro, Chiara Tarracchini, Leonardo Mancabelli, Gabriele Andrea Lugli et autres

Environmental pollution from a wide range of compounds poses serious ecological and health risks. While bioremediation offers a promising solution, its application is limited by fragmented genomic resources and unsatisfactory understanding of microbial biodegradation pathways. Here, we developed the Microbial BioRemediation (MBR) …

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