Birgit Mertens

A Transcriptomic Biomarker to Classify Chemical-Induced Histone Deacetylase Inhibition in Human HepaRG Cells

Julie K. Buick, Eunnara Cho, Anouck Thienpont, Andrew Williams et autres

ca, be (code pays fourni par la source)

Advancing genotoxicity assessment with transcriptomic biomarkers: From 2D to 3D HepaRG spheroid models

Mariam Saleh, Kevin Hogeveen, Anouck Thienpont, Emmanuel Demuynck et autres

The development of New Approach Methodologies (NAMs) for genotoxicity testing is needed to support the transition towards animal-free human-relevant chemical genotoxicity assessment. In this context, we investigated the predictive power of two transcriptomic biomarkers developed in 2D cell systems (GENOMARK and TGx-DDI) …

fr, be (code pays fourni par la source)

Hazard characterization of Alternaria toxins – filling data gaps on in vitro genotoxicity

Anne‐Cathrin Behr, Ariane Vettorazzi, Camille Streel, Birgit Mertens et autres

Abstract Alternaria toxins are naturally occurring food contaminants with limited and often inconsistent genotoxicity and mutagenicity data. Within the European Partnership for the Assessment of Risks from Chemicals (PARC), an OECD-aligned in vitro testing strategy was applied to fill existing data gaps …

de, es, be, pt, si, at (code pays fourni par la source)

Implementation Plan for the proposed Qualification System for New Approach Methodologies (NAMs) in the food and feed sector with focus on nanomaterial risk assessment

Andrea Haase, Shirin M. Usmani, Alessia Bogni, Cecilia Bossa et autres

Abstract Many promising New Approach Methodologies (NAMs) emerged in the last decades but only some are taken up as OECD Test Guidelines (TGs). For regulatory decision‐making data from non‐guideline studies is primarily considered as mechanistic support rather than direct evidence. The nanotechnology …

de, Afrique du Sud, it, fr, be, nl, lu, sg (code pays fourni par la source)

Copper oxide nanoparticles: from EU-regulatory landscape and mechanistic toxicity towards a cuproptosis-linked adverse outcome pathway

Sophie Scholz, Julia Prinz, Linde Sevenants, Andrea Holzwarth et autres

Abstract Copper is an essential trace element, yet concerns regarding its toxic potential have gained increasing attention, particularly with regard to nanoparticulate forms of copper oxides. Both CuO and Cu 2 O are currently authorised in the EU for use in agriculture, …

de, be (code pays fourni par la source)

The genotoxic properties of leaf extracts from three common congolese medicinal plants, Cogniauxia podolaena Baill. (1839), Dissotis rotundifolia (Sm.) Triana (1872) and Emilia coccinea G. Don (1839) using the Ames test, the in vitro micronucleus test and the comet assay

Didier Dianzuangani Lusimbamo, Davie Cappoen, Odette Kabena Ngandu, Félicien Lukoki Luyeye et autres

Cogniauxia podolaena, Dissotis rotundifolia, and Emilia coccinea are widely used in the Democratic Republic of Congo to treat various ailments, but also as contraceptives, laxatives, painkillers, and to combat malaria. Although commonly used in traditional medicine, no genotoxicity or mutagenicity data exist …

République démocratique du Congo, be (code pays fourni par la source)

A Data-Driven Approach for the Development of a Time-informed Adverse Outcome Pathway-network for Cardiotoxicity of Environmental Chemicals

Alexandra Schaffert, Sivakumar Murugadoss, Tom Roos, Nunzia Linzalone et autres

Abstract We present a novel Adverse Outcome Pathway (AOP) network for environmental chemical-induced cardiotoxicity using a bottom-up, data-driven AOP development approach. Mechanistic endpoints were systematically extracted from 339 in vitro and in vivo studies, yielding 1,759 Key Event (KE) entries and 4,938 …

fi, us, nl, ro, ru, at (code pays fourni par la source)

SILIFOOD: a tool to support the risk assessment of non-evaluated food contact material substances

Camille Streel, Ilse Van Overmeire, Gianluca Selvestrel, Alessandra Roncaglioni et autres

• Automatic regulatory and toxicological data collection from different sources • Integration of VEGA (Q)SAR models to predict toxicological hazard • Existing and predicted toxicological data combined in one report • A tool to aid the safety assessment of food contact material …

be, it (code pays fourni par la source)

Variability and uncertainty of data from genotoxicity Test Guidelines: What we know and why it matters

Giuseppa Raitano, Tessa E. Pronk, Chiara Laura Battistelli, Cecilia Bossa et autres

Abstract This review comprehensively examines the variability and uncertainty associated with test guideline (TG)-conform genotoxicity data and explores the respective implications for the integration of non-animal-methods (NAMs) into regulatory frameworks. Historical amendments to OECD TGs are mapped to reveal the method’s evolution …

it, nl, gr, at, fr, be (code pays fourni par la source)

P30-74 How advancements in OECD genotoxicity TGs improve chemical safety assessments and challenge retrospective data analysis for NAM based IATA development

Vasiliki I. Hatzi, Dimitra Nikolopoulou, Eugenia Chaideftou, Chiara Laura Battistelli et autres

Revisions of OECD Test Guidelines (TGs) over time have marked significant advancements in genotoxicity testing, focusing on improved documentation and reporting quality, adaptations of experimental protocols to new scientific and technical knowledge and deeper integration of statistical and biological considerations in data …

gr, at, it, am, nl, fr, be (code pays fourni par la source)

P30-04 Proposal for a qualification system for New Approach Methodologies (NAMs) in the food and feed sector

Sara Usmani, Andrea Haase, José G. Barroso, Alessia Bogni et autres

de, it, fr, be, nl, lu (code pays fourni par la source)

P18-65 Advancing the Grouping and Harmonization of Similar Key Events in the AOP Wiki: Ontology-Based Key Event Component Combinations as Catalysts for Integration

Julija Filipovska, Karine Audouze, Jonathan H. Blum, Laure‐Alix Clerbaux et autres

mk, fr, ch, be, us, bg, gb, it, nl, se, cz, jp (code pays fourni par la source)