Wen‐Lin Su

Comparative impact of bacteriophage disinfection on hospital microbiota and multidrug-resistant organisms in critical care units

Yi‐Hsuan Chen, Hsueh-Wen Chung, Li‐Kuang Chen, Ming-Chin Chan et autres

BACKGROUNDS: Currently used disinfection methods for multidrug-resistant organisms (MDROs) in intensive care units (ICUs) have limitations. This study evaluated the efficacy of bacteriophage disinfection compared to traditional methods. METHODS: Initially, 30 ICU rooms housing patients with cultured MDROs were included between 2020-2022 …

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Carbon Emissions and Treatment Efficiency in Chronic Obstructive Pulmonary Disease: The Impact of Inhaled Bronchodilators and Corticosteroids

Lun-Yu Jao, Mei‐Chen Yang, Chung Lee, Yao‐Kuang Wu et autres

Background: Inhaled therapies are essential for chronic obstructive pulmonary disease (COPD) management but also contribute to healthcare-related carbon emissions. Real-world evidence linking inhaler-related carbon burden to clinical outcomes remains limited. This study evaluated the relationship between inhaler-related CO 2 emissions and clinical …

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Comparisons of Continuous Positive Airway Pressures Determined by Conventional Manual Titration in a Sleep Center, During Sleep Endoscopy, and Auto-Titration at Home

Yi-Chih Huang, Chou-Chin Lan, Wen‐Lin Su, Ian‐Jiun Kuo et autres

IMPORTANCE: Drug-induced sleep endoscopy (DISE) could be valuable to determine an appropriate therapeutic pressure for obstructive sleep apnea (OSA). OBJECTIVE: The continuous positive airway pressure (CPAP) determined by DISE was regarded as equal to the conventional titrating pressure. There is no study …

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Bronchial Hyperreactivity in the COVID-19 Era: The Impact of SARS-CoV-2 Infection and COVID-19 Vaccination in Patients with Respiratory Symptoms

Mei‐Chen Yang, Chung Lee, Lun-Yu Jao, Chun‐Yao Huang et autres

Introduction: Persistent respiratory symptoms are commonly reported following coronavirus disease 2019 (COVID-19). Although COVID-19 vaccines are effective, concerns remain regarding their potential impact on airway hypersensitivity. The relationship between SARS-CoV-2 infection, vaccination, and bronchial hyperresponsiveness remains unclear. Materials and Methods: This retrospective …

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Psychosocial and behavioral effects on patient caregivers of prolonged mechanical ventilation in a respiratory care center: A longitudinal study

Meng-Yi Liu, Pei-Shan Hsu, Mei-Chen Yang, Tzu-Yu Tseng et autres

A BSTRACT Objectives: Prolonged mechanical ventilation presents substantial challenges not only for patients but also for family caregivers. Although clinical outcomes are often prioritized, the psychosocial and behavioral burden experienced by caregivers remains underexplored, particularly during hospitalization in respiratory care centers (RCCs). …

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Molecular Biomarkers and More Efficient Therapies for Sepsis

Wen‐Lin Su, Sheng-Kang Chiu, Chih‐Hao Shen, Yi-Ting Chen

Sepsis remains a leading cause of morbidity and mortality worldwide, underscoring the urgent need for advances in diagnosis, prognostication, and therapeutic strategies. This Special Issue gathers high-quality contributions exploring the various molecular biomarkers and novel therapeutic approaches aimed at improving outcomes in …

High-Flow Nasal Cannula Application After Extubation in Acute Respiratory Failure Patients

Wen‐Chi Chao, Shen-Yung Wang, Chang-Yi Lin, Hou-Tai Chang et autres

Background: The optimal timing of high-flow nasal cannula (HFNC) application in acute respiratory failure patients remains uncertain. This study aimed to investigate the impact of HFNC on the outcomes of patients with acute respiratory failure, focusing on its use after extubation. Methods: …

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Early fungal colonization and infection as an independent predictor of in-hospital mortality in mechanically ventilated COVID-19 patients: A nationwide target trial emulation study in Taiwan

Yao-Kuang Wu, Hsueh-Wen Chung, Wei‐Chih Chen, Kuang‐Yao Yang et autres

To evaluate the impact of fungal colonization and infection phenotypes and other prognostic factors on in-hospital mortality among mechanically ventilated COVID-19 patients (n = 376) admitted to ICUs during the first wave of the pandemic in Taiwan. A target trial emulation framework …

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Interrelationship Between Obstructive Sleep Apnea Syndrome and Small Airway Disease: A Comprehensive Review

Chou-Chin Lan, Chung Lee, Lun-Yu Jao, Yao-Kuang Wu et autres

Study Objectives: This review aims to explore the epidemiology, pathophysiology, risk factors, and diagnostic approaches of obstructive sleep apnea syndrome and small airway disease, emphasizing their interrelationship and implications for clinical management. Methods: A comprehensive analysis of the literature was conducted to …

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Unraveling the Immune Landscape of Chronic Obstructive Pulmonary Disease: Insights into Inflammatory Cell Subtypes, Pathogenesis, and Treatment Strategies

Chou‐Chin Lan, Mei‐Chen Yang, Wen‐Lin Su, Kuo-Liang Huang et autres

Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disorder characterized by persistent airway inflammation and progressive airflow limitation, resulting in a significant global health burden and high mortality. This narrative review synthesizes the current evidence on the roles of leukocyte subtypes-including …

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Assessing Traditional Chinese Medicines for Anti‐Dengue Using a National Health Insurance Research Database and Bioassays

Wen‐Lin Su, Hao-Chan Lo, Jeng‐Wei Lu, I‐Chuan Yen et autres

Dengue fever is a widespread viral infectious disease transmitted by mosquitoes. Despite the potentially fatal consequences for some individuals, no antiviral drugs have been approved for the treatment of this disease. Taiwan's National Health Insurance Database (NHID) holds extensive medical records for …

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Utility of Veillonella parvula polymerase chain reaction in diagnosing aspiration pneumonia: a prospective observational study

Yao‐Kuang Wu, Mei‐Chen Yang, Hsueh-Wen Chung, Chou‐Chin Lan et autres

Background Aspiration pneumonia is a critical concern, particularly in older adults with comorbidities. Micro-aspiration is often underdiagnosed due to the lack of precise diagnostic tools. This study evaluated the utility of anaerobic PCR for Veillonella parvula compared with traditional diagnostic methods for …

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