Utility of Veillonella parvula polymerase chain reaction in diagnosing aspiration pneumonia: a prospective observational study
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Le résumé fourni par la source
Background Aspiration pneumonia is a critical concern, particularly in older adults with comorbidities. Micro-aspiration is often underdiagnosed due to the lack of precise diagnostic tools. This study evaluated the utility of anaerobic PCR for Veillonella parvula compared with traditional diagnostic methods for predicting aspiration pneumonia. Methods This prospective observational case–control study included patients with new-onset acute respiratory failure requiring mechanical ventilation in intensive care units (ICUs) at a Taiwan medical centre (2022–2024). Demographic data, laboratory results and tracheal aspirates were collected within 48 h of ICU admission. PCR results for Veillonella spp. and V. parvula, along with pepsin and α-amylase levels, were analysed. Pneumonia diagnosis was confirmed by two pulmonologists. Results Among 87 patients (53 with aspiration pneumonia, 34 without), aspiration pneumonia primarily affected the right side and had atypical phenotypes. Demographics, traditional risk factors, comorbidities and disease severity were similar between groups. Veillonella spp. PCR showed higher sensitivity (92.5%) and specificity (97.1%) than V. parvula PCR (79.2% and 97.1%), chest radiographs with symptoms (73.6% and 88.2%), α-amylase (28.3% and 64.7%) and pepsin (73.6% and 38.2%). Logistic regression revealed that Veillonella spp. PCR had an adjusted odds ratio of 467.2 (95% CI 30.96–7049.4, p<0.001) for predicting aspiration pneumonia. Patients with aspiration pneumonia had longer ICU stays (18.28 days versus 13.03 days, p=0.001) and ventilator days (17.30 days versus 12.09 days, p=0.002). Conclusions Veillonella spp. PCR offers better diagnostic sensitivity and specificity than traditional methods for aspiration pneumonia, potentially guiding antibiotic stewardship.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Utility of <i>Veillonella parvula</i> polymerase chain reaction in diagnosing aspiration pneumonia: a prospective observational study
- Date Crossref
- 27/02/2025
- Éditeur
- European Respiratory Society (ERS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Tzu Chi University pays non établi dans la noticeUniversité ou école supérieure
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Taipei Tzu Chi Hospital Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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National Yang Ming Chiao Tung University pays non établi dans la noticeUniversité ou école supérieure
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Cardinal Tien College of Healthcare and Management pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Cardinal Tien Junior College of Healthcare and Management Department of Nursing pays non établi dans la noticeUniversité ou école supérieure
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College of Nursing Department of Nursing pays non établi dans la noticeUniversité ou école supérieure
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Department of Pathology and Laboratory Medicine pays non établi dans la noticeStructure de recherche
Tzu Chi University, Department of Internal Medicine — Taipei Tzu Chi Hospital et National Yang Ming Chiao Tung University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.