Kuang‐Yao Yang

Post-traumatic stress disorder among family members of patients with prolonged mechanical ventilation

Wei‐Chih Chen, Chia-Fen Tsai, Kuang‐Yao Yang

Background: The incidence and risk factors contributing to post-traumatic stress disorder (PTSD) symptoms in family members of patients undergoing prolonged mechanical ventilation (PMV) remain unclear. This study aims to investigate the prevalence of PTSD symptoms and associated factors in family members of …

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Induced pluripotent stem cell-derived conditioned medium, as well as nintedanib, ameliorates bleomycin-induced pulmonary fibrosis via suppressing endothelial-mesenchymal transition

Wen-Kuang Yu, Yi-Ping Yang, Hsiao‐Chin Shen, Shih-Hwa Chiou et autres

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Bone morphogenetic protein 10 serves as a biomarker and a potential therapeutic target for endothelial dysfunction in endotoxin-induced acute lung injury

Wen-Kuang Yu, Wei‐Chih Chen, Hsiao‐Chin Shen, Chuan-Yen Sun et autres

BACKGROUND: Endothelial dysfunction plays a crucial role in the development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in critically ill patients. Bone Morphogenetic Protein 10 (BMP10) has been demonstrated to promote cardiovascular development and cell proliferation, support endothelial …

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Frailty-stratified effectiveness of SGLT2 inhibitors versus DPP-4 inhibitors and GLP-1 receptor agonists on pulmonary outcomes in type 2 diabetes: a nationwide cohort study

Lin‐Chieh Meng, Hui-Min Chuang, Hsi‐Yu Lai, Ho‐Min Chen et autres

Background: The coexistence of type 2 diabetes (T2D) and chronic obstructive pulmonary disease (COPD) poses significant clinical challenges, particularly in aging populations. While sodium-glucose cotransporter 2 inhibitors (SGLT2i) show promise for pulmonary protection, their effectiveness compared to other newer antidiabetic agents across …

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PaCO2 responders of prone positioning in acute respiratory distress syndrome had better survival rates: A multicenter cohort study in Taiwan

Ko-Wei Chang, Shaw‐Woei Leu, Han‐Chung Hu, Ming-Cheng Chan et autres

Background Prone positioning has demonstrated decreased mortality in moderate to severe acute respiratory distress syndrome (ARDS) patients. This study aimed to investigate the gas exchange effect of prone positioning in moderate to severe ARDS patients. Methods This retrospective study includes eight tertiary …

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616 | REAL‐WORLD BURDEN OF DISEASE, TREATMENT (tx) PATTERNS, AND OUTCOMES IN PATIENTS WITH MANTLE CELL LYMPHOMA

Alvaro J. Alencar, Mei Xue, Pao‐Yu Chuang, W. Furnback et autres

responses and outcomes.Therefore, DM is a viable strategy especially for elderly MCL patients with comorbidities or drugrelated AEs.

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Attenuation of Cuproptosis Through Histone Deacetylase Inhibition: A Novel Strategy for Alleviating Acute Lung Injury

H.-C. Shen, Wei‐Kuang Yu, C.-Y. Sun, Wan‐Chin Chen et autres

Abstract Background: Acute respiratory distress syndrome/ acute lung injury (ARDS/ALI) are significant causes of respiratory failure, associated with high mortality and often underrecognized. The pathophysiology of ALI is complex, with growing evidence indicating the involvement of regulated cell death (RCD) mechanisms in …

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Comparison of Clinical Characteristics and Viral Shedding Duration Among SARS-CoV-2 Variants in COVID-19 Patients With ARDS: A Retrospective Cohort Study

I‐Chen Chen, H.-C. Shen, Chenyu Sun, Wan‐Chin Chen et autres

Abstract Background Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in significant global morbidity and mortality since 2020 and can cause respiratory failure resembling acute respiratory distress syndrome (ARDS). Studies indicate that different viral …

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High-Flow Nasal Cannula Application After Extubation in Acute Respiratory Failure Patients

Wen‐Chi Chao, Shen-Yung Wang, Chang-Yi Lin, Hou-Tai Chang et autres

Background: The optimal timing of high-flow nasal cannula (HFNC) application in acute respiratory failure patients remains uncertain. This study aimed to investigate the impact of HFNC on the outcomes of patients with acute respiratory failure, focusing on its use after extubation. Methods: …

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Early fungal colonization and infection as an independent predictor of in-hospital mortality in mechanically ventilated COVID-19 patients: A nationwide target trial emulation study in Taiwan

Yao-Kuang Wu, Hsueh-Wen Chung, Wei‐Chih Chen, Kuang‐Yao Yang et autres

To evaluate the impact of fungal colonization and infection phenotypes and other prognostic factors on in-hospital mortality among mechanically ventilated COVID-19 patients (n = 376) admitted to ICUs during the first wave of the pandemic in Taiwan. A target trial emulation framework …

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The Mechanical Power in Patients with Acute Respiratory Distress Syndrome Undergoing Prone Positioning Can Predict Mortality

Ko‐Wei Chang, Shaw‐Woei Leu, Han‐Chung Hu, Ming-Cheng Chan et autres

Background/Objectives: Mechanical power (MP) refers to ventilator-delivered energy to the lungs, which may induce lung injury. We examined the relationship between MP and mortality in patients with acute respiratory distress syndrome (ARDS) who underwent prone positioning. Methods: This multicenter retrospective study included …

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Recommendation for the use of respiratory syncytial virus vaccines

Ping‐Ing Lee, Yhu‐Chering Huang, Hsiao‐Sheng Liu, Shee‐Uan Chen et autres

Respiratory syncytial virus (RSV) is the most common pathogen for young children hospitalized with bronchiolitis and pneumonia. Most infections occur below 1 year of age. RSV is also a significant viral pathogen for adults with respiratory tract infection. Vaccines targeting the pre-fusion …

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