Accès ouvert
2026
preprint
OpenAlex
Isabella R. Willcocks, Alexander L. Richards, Sophie E. Legge, Peter Holmans et autres
Abstract Schizophrenia and bipolar disorder are diagnostically distinct categories that overlap substantially in clinical features and genetic aetiology. Understanding genetic variants that contribute liability specifically to each disorder can offer insights into biological processes that differentiate them. Here we used Case-Case GWAS …
gb
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2026
article
OpenAlex
Alastair G. Cardno, E. Jane Marshall, T. Toulopoulou, Eugenia Kravariti et autres
Background Schizophrenia and psychosis have high twin heritability (approximately 80%), but these general estimates may hide aetiological variation. This can be investigated by using syndromes based on key psychotic symptom combinations. Aims To investigate concordance, and heritability where calculable, of psychotic syndromes …
gb, tr, gr, us, sr
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Accès ouvert
2025
article
OpenAlex
Alastair G. Cardno, Hein Heuvelman, Sophie E. Legge, James Walters et autres
Background Some psychotic experiences in the general population show associations with higher schizophrenia and other mental health-related polygenic risk scores (PRSs), but studies have not usually included interviewer-rated positive, negative and disorganised dimensions, which show distinct associations in clinical samples. Aims To …
gb
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Accès ouvert
2025
article
OpenAlex
Tariq Mahmood, Alastair G. Cardno, Emi Obode
Aims: Studies have shown an elevated risk of psychosis among migrants and ethnic minorities, but there has been little investigation of risks for Irish and Chinese ethnic groups in the UK. The aim of this study is to investigate the risk of …
gb
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Accès ouvert
2025
article
OpenAlex
Eugenia Kravariti, Anna Georgiades, Alastair G. Cardno, Fergus Kane et autres
BACKGROUND: Psychiatric research is increasingly embracing a paradigm shift from categorical diagnoses to neurobiologically meaningful dimensions that cross current diagnostic boundaries. This transposition calls for redefining endophenotypes to accommodate transdiagnostic vulnerabilities. We sought to identify shared and disorder-specific neurocognitive endophenotypes for schizophrenia, …
gb, gr, us, dk, sr, tr
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Accès ouvert
2024
article
OpenAlex
Alastair G. Cardno, Judith Allardyce, Steven C. Bakker, Timothea Toulopoulou et autres
Background Positive, negative and disorganised psychotic symptom dimensions are associated with clinical and developmental variables, but differing definitions complicate interpretation. Additionally, some variables have had little investigation. Aims To investigate associations of psychotic symptom dimensions with clinical and developmental variables, and familial …
gb, tr, gr, us, sr
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Accès ouvert
2024
review
OpenAlex
Adam Jameson, Justine Tomlinson, Kristina Medlinskiene, Dane Howard et autres
Pharmacogenomic (PGx) testing can help personalise psychiatric prescribing and improve on the currently adopted trial-and-error prescribing approach. However, widespread implementation is yet to occur. Understanding factors influencing implementation is pertinent to the psychiatric PGx field. Normalisation Process Theory (NPT) seeks to understand …
gb
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Accès ouvert
2024
review
OpenAlex
Adam Jameson, Justine Tomlinson, Kristina Medlinskiene, David J. Howard et autres
Abstract Introduction Prescribing of psychotropic medicines is largely led by a trial-and-error approach. Treatment inefficacy, side effects and poor adherence are common challenges.[1] Pharmacogenomics (PGx) studies how genetic variability influences medication response. PGx Testing (PGxT) can identify relevant gene variants and help …
gb
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Accès ouvert
2024
article
OpenAlex
Sophie E. Legge, Antonio F. Pardiñas, Grace Woolway, Elliott G Rees et autres
Importance: Large-scale biobanks provide important opportunities for mental health research, but selection biases raise questions regarding the comparability of individuals with those in clinical research settings. Objective: To compare the genetic liability to psychiatric disorders in individuals with schizophrenia in the UK …
gb
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Accès ouvert
2024
article
OpenAlex
Adam Jameson, Muhammad Salman Faisal, Beth Fylan, Greg C. Bristow et autres
BACKGROUND: Prescribing drugs for psychosis (antipsychotics) is challenging due to high rates of poor treatment outcomes, which are in part explained by an individual's genetics. Pharmacogenomic (PGx) testing can help clinicians tailor the choice or dose of psychosis drugs to an individual's …
gb
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Accès ouvert
2024
article
OpenAlex
James Richard O’Neill, Adam Jameson, Samantha Louise McLean, Michael F. Dixon et autres
Background: Presently, there is limited guidance on the maximal dosing of psychosis drugs that is based on effectiveness rather than safety or toxicity. Current maximum dosing recommendations may far exceed the necessary degree of dopamine D 2 receptor blockade required to treat …
gb
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Accès ouvert
2024
article
OpenAlex
Alastair G. Cardno, Soumaya Nasser el din, Deline du Toit, Faiz-ur Rehman et autres
Background : Psychotic symptoms and self-rated schizotypal phenomena have similar dimensional structures. Additionally, dissociative phenomena have conceptual links with psychosis/schizotypy and all of these phenotypes are associated with adverse life events (ALEs). The relationships between these factors among individuals with psychotic disorders …
gb, my
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