Associations of psychotic symptom dimensions with clinical and developmental variables in twin and general clinical samples
Rattachement africain : gb, tr, gr, us, sr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background Positive, negative and disorganised psychotic symptom dimensions are associated with clinical and developmental variables, but differing definitions complicate interpretation. Additionally, some variables have had little investigation. Aims To investigate associations of psychotic symptom dimensions with clinical and developmental variables, and familial aggregation of symptom dimensions, in multiple samples employing the same definitions. Method We investigated associations between lifetime symptom dimensions and clinical and developmental variables in two twin and two general psychosis samples. Dimension symptom scores and most other variables were from the Operational Criteria Checklist. We used logistic regression in generalised linear mixed models for combined sample analysis (n = 875 probands). We also investigated correlations of dimensions within monozygotic (MZ) twin pairs concordant for psychosis (n = 96 pairs). Results Higher symptom scores on all three dimensions were associated with poor premorbid social adjustment, never marrying/cohabiting and earlier age at onset, and with a chronic course, most strongly for the negative dimension. The positive dimension was also associated with Black and minority ethnicity and lifetime cannabis use; the negative dimension with male gender; and the disorganised dimension with gradual onset, lower premorbid IQ and substantial within twin-pair correlation. In secondary analysis, disorganised symptoms in MZ twin probands were associated with lower premorbid IQ in their co-twins. Conclusions These results confirm associations that dimensions share in common and strengthen the evidence for distinct associations of co-occurring positive symptoms with ethnic minority status, negative symptoms with male gender and disorganised symptoms with substantial familial influences, which may overlap with influences on premorbid IQ.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Associations of psychotic symptom dimensions with clinical and developmental variables in twin and general clinical samples
- Date Crossref
- 30/10/2024
- Éditeur
- Royal College of Psychiatrists
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Leeds Division of Psychological and Social Medicine pays non établi dans la noticeUniversité ou école supérieure
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Cardiff University Centre for Neuropsychiatric Genetics and Genomics pays non établi dans la noticeUniversité ou école supérieure
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University of Edinburgh Centre for Clinical Brain Sciences pays non établi dans la noticeUniversité ou école supérieure
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King's College London Department of Psychosis Studies pays non établi dans la noticeUniversité ou école supérieure
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Bilkent University Department of Psychology and National Magnetic Resonance Research Center (UMRAM) pays non établi dans la noticeUniversité ou école supérieure
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National and Kapodistrian University of Athens Department of Psychiatry pays non établi dans la noticeUniversité ou école supérieure
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Icahn School of Medicine at Mount Sinai Department of Psychiatry pays non établi dans la noticeUniversité ou école supérieure
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University College London Department of Clinical Educational and Health Psychology pays non établi dans la noticeUniversité ou école supérieure
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Anton de Kom University of Suriname Psychology Department pays non établi dans la noticeUniversité ou école supérieure
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Leeds and York Partnership NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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Cygnet Hospital Wyke pays non établi dans la noticeÉtablissement de santé
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Cygnet Healthcare Ltd pays non établi dans la noticeÉtablissement de santé
Division of Psychological and Social Medicine — University of Leeds, Centre for Neuropsychiatric Genetics and Genomics — Cardiff University et Centre for Clinical Brain Sciences — University of Edinburgh, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.